The relationship between neutrophil lymphocyte ratio and clinical outcomes after snakebite in pediatric patients

Abstract

Öz Purpose: Snake venom has serious cardiotoxic, neurotoxic, nephrotoxic effects. The neutrophil-tolymphocyte ratio (NLR) is a new biomarker of inflammation and can be used as an indicator and prognositic marker of inflammation. In this study we aimed to analyze the association with clinical outcomes of pediatric patients with snakebite envenomation, and NLR. Materials and Methods: A total of 61 pediatric patients with snakebite who admitted to a tertiary university hospital and a children's hospital between July 2012 and July 2017 were included in the study. Demographic features, clinical findings and complications of snakebite, length of stay in hospital, NLR at admission (NLR1), and NLR at the twelfth hour (NLR2) and NLR at the discharge (NLR3) and mean platelet volume (MPV) were retrospectively reviewed and recorded. Results: There was a positive correlation between NLR1 and the length of hospital stay. We found that as the level of NLR1 increased, the length of hospitalization was prolonged. NLR1 level increased as the disease stage progressed, but it was not statistically significant. Our study showed that when the severity of the illness increased, the length of hospital stay was significantly prolonged. Conclusion: The study revealed a positive correlation with NLR and severity of the illness. We claim that NLR at admission can be a useful marker for predicting severe clinical course and prolonged hospital length of stay for pediatric patients with snake envenomation.

The Role of Procalcitonin in Predicting Necessity of Antivenom Administration and Clinical Severity in Snake Bites

“…The World Health Organization (WHO) estimates that there are a total of 5.4 million snake bites annually worldwide of which approximately 2.7 million are venomous, and approximately 5% of these venomous snake bites result in death (137,880 deaths per year) (WHO 2019). Snake bites in Turkey commonly occur in hot regions such as the Southeastern, Eastern Anatolia regions and Mediterranean region where our hospital is located (Aslan et al 2019). Out of more than 40 snake species living in our country, 28 species are non-venomous while 13 species are venomous, and the most common group among poisonous species is the Viperidae (viper) family (Bilir 2020).…”