The relationship between neutrophil-lymphocyte, platelet–lymphocyte ratio and cognitive functions in bipolar disorder

Aykut, Demet Sağlam; Arslan, Filiz Civil; Karagüzel, Evrim Özkorumak; Aral, Gizem; Karakullukçu, Serdar

doi:10.1080/08039488.2017.1397192

Cited by 30 publications

(13 citation statements)

References 30 publications

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“…Some studies have suggested that PDW is a more specific marker of platelet activation and is associated with inflammatory vascular damage [28]. Sağlam Aykut et al, who studied cognitive function and NLR, an inflammation marker like PDW, found a negative correlation between inflammatory processes and cognitive functions in BD patients [29]. These studies may suggest that PDW is a predictor of cognitive decline in BD and UD patients due to neuroinflammation.…”

Section: Discussionmentioning

confidence: 96%

PDW and RDW are new parameters for bipolar episodes and unipolar depression

Gündoğmuş¹,

Algül²,

Karagöz³

et al. 2018

Psychiatry and Clinical Psychopharmacology

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INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD. OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic. RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW. CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings.

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Section: Discussionmentioning

confidence: 96%

PDW and RDW are new parameters for bipolar episodes and unipolar depression

Gündoğmuş¹,

Algül²,

Karagöz³

et al. 2018

Psychiatry and Clinical Psychopharmacology

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“…A Korean study ( 15 ) also found that NLR in the acute phase of stroke was independently associated with an increased risk of PSCI at 3 months and that the highest quintile (NLR ≥ 3.80) increased the risk of PSCI by 3.26-fold compared with that of the lowest quintile ( ≤ 1.57). Other studies, meanwhile, have demonstrated that an elevated NLR is independently associated with an increased risk of AD in people aged > 65 years ( 16 ), with a correlation between NLR and CI ( 13 , 17 , 18 ). A Chinese study of the mild cognitive impairment (MCI) population ( 19 ) revealed that NLR was significantly higher in the MCI group than in that with normal cognitive function, with subjects having an NLR ≥ 2.07 with a nearly six-fold increased risk relative to those with an NLR < 2.07.…”

Section: Discussionmentioning

confidence: 99%

High neutrophil percentage and neutrophil-lymphocyte ratio in acute phase of ischemic stroke predict cognitive impairment: A single-center retrospective study in China

Shang

Shen

et al. 2022

Front. Neurol.

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Background and aimsRecently, various hemocyte and blood cell ratios have garnered researchers' attention, as a low-cost, widely prevalent, and easy-to-measure index for diagnosing and predicting disease. Therefore, we sought to investigate the effect and predictive value of the peripheral blood neutrophil percentage and neutrophil-lymphocyte ratio (NLR) in the acute phase of ischemic stroke (AIS) in post-stroke cognitive impairment (PSCI).MethodsWe selected 454 patients with mild AIS and acquired general clinical data. The patients were divided into PSCI and post-stroke no cognitive impairment (PSNCI) groups according to their Montreal Cognitive Assessment (MOCA) scores. We assessed whether there were differences in clinical data, peripheral blood neutrophil percentage, and NLR values between the different groups. We also analyzed the independent influences on the occurrence of PSCI using a binary logistic regression. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of the above inflammatory indicators and models containing different inflammatory indicators for PSCI.ResultsIn total, 454 patients were included, of whom 253 (55.7%) patients were in the PSCI group, with a mean age of 62.15 ± 7.34 years and median neutrophil percentage and NLR of 0.64 (0.32–0.95) and 2.39 (0.71–54.46), respectively. Both neutrophil percentage (adjusted OR = 1.025; 95% confidence interval: 1.005–1.406) and NLR as a categorical variable (Q5, adjusted OR = 2.167; 95% CI: 1.127–4.166) were independent risk factors for PSCI, and the Q5 group (NLR ≥ 4.05) had significantly worse overall cognition and executive function.ConclusionsNeutrophil percentage and NLR in the acute phase of AIS were independently associated with PSCI, and a high NLR was strongly associated with executive function. In addition, neutrophil percentage and NLR have diagnostic values for PSCI.

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“…Thus, these immunological indicators can also be used as a reference for the clinical treatment and outcomes of bipolar disorders. Thirdly, studies have shown that some non-specific immunological indicators (such as central granulocyte/lymphocyte ratio) can predict the suicide risk and cognitive level of patients with bipolar disorder (48,49), which has practical significance for community health management and social function rehabilitation of patients. Finally, through investigation of the pathogenesis of autoimmune diseases, researchers have further speculated about the pathogenesis of bipolar disorder and proposed various mechanisms including cytokine-induced change of monoamine, increased oxidative stress, pathological excessive activation of microglia, excessive activation of the hypothalamus-pituitary-adrenal (HPA) axis, and immune disorder associated with sleep (45).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis

Chen¹,

Jiang²,

Zhang³

2021

Ann Palliat Med

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Background: At the end of the last century, genome-wide association studies revealed a significant genetic association between bipolar disorder and autoimmune diseases. Subsequently, the theory of immune pathogenesis of bipolar disorder gradually formed, and the research on autoimmune diseases and bipolar comorbidities began to extend to other diseases, but their correlation is still controversial. To explore the differences in the prevalence of bipolar disorder in patients with autoimmune disease and normal healthy people through meta-analysis, and to examine the relationship between bipolar disorder and autoimmune disease by reviewing the relevant literature. Methods: The Cochrane, PubMed, and Embase databases were searched by computer from the date of inception of the database to July 2020. The main topics of the search were based on common autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, multiple sclerosis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, pemphigus, and Sjogren's syndrome. The databases were comprehensively searched for controlled studies regarding the prevalence of bipolar disorder in patients with autoimmune diseases. Review Manager 5.3 software was used for meta-analysis. Results: In total, 10 cohort and case control studies were included. From these, 16 control groups were extracted based on nine autoimmune diseases. The meta-analysis demonstrated that the incidence of bipolar disorder was significantly increased in patients with autoimmune disease compared to patients without autoimmune disease, [mean difference (MD) =1.54, 95% confidence interval (CI): 1.28-1.86, P<0.00001]. Also, in the meta-analysis based on five cross-sectional analyses (in which a total of five control groups were extracted based on five autoimmune diseases), the high comorbidity rate of autoimmune diseases and bipolar disorder was verified (MD =2.23, 95% CI: 1.62-3.07, P<0.00001). Conclusions: The prevalence of bipolar disorder is markedly higher in patients with autoimmune disease. Yet, more basic research is needed to verify the special significance of immune mechanisms in bipolar disorder.

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The relationship between neutrophil-lymphocyte, platelet–lymphocyte ratio and cognitive functions in bipolar disorder

Abstract: This study revealed negative correlation between NLR and Stroop interference scores. We need further prospective studies with larger sample size to investigate role of inflammation on cognitive functions.

Cited by 30 publications

References 30 publications

PDW and RDW are new parameters for bipolar episodes and unipolar depression

PDW and RDW are new parameters for bipolar episodes and unipolar depression

High neutrophil percentage and neutrophil-lymphocyte ratio in acute phase of ischemic stroke predict cognitive impairment: A single-center retrospective study in China

The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis

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