The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue

Poledne, R.; Lesná, I. Králová; Králová, Anna; Froněk, Jiří; Čejková, Soňa

doi:10.1194/jlr.p068015

Cited by 23 publications

(20 citation statements)

References 29 publications

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“…Obesity and obesity-related metabolic disorders are associated with elevated plasma TG levels, high low-density lipoprotein (LDL)-Chol and low high-density lipoprotein (HDL)-Chol contents, with non-HDL levels positively associated with pro-inflammatory ATMs even in healthy subjects [38,39]. Within blood vessel, TG is transported in the form of lipoproteins, including VLDL, which can bind to the VLDL receptor (VLDLR) at the surface of adipocytes and macrophages for TG uptake [40,41].…”

Section: Vldl/vldlrmentioning

confidence: 99%

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

Dahik

Frisdal

Goff

2020

IJMS

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Obesity and its two major comorbidities, insulin resistance and type 2 diabetes, represent worldwide health issues whose incidence is predicted to steadily rise in the coming years. Obesity is characterized by an accumulation of fat in metabolic tissues resulting in chronic inflammation. It is now largely accepted that adipose tissue inflammation underlies the etiology of these disorders. Adipose tissue macrophages (ATMs) represent the most enriched immune fraction in hypertrophic, chronically inflamed adipose tissue, and these cells play a key role in diet-induced type 2 diabetes and insulin resistance. ATMs are triggered by the continuous influx of dietary lipids, among other stimuli; however, how these lipids metabolically activate ATM depends on their nature, composition and localization. This review will discuss the fate and molecular programs elicited within obese ATMs by both exogenous and endogenous lipids, as they mediate the inflammatory response and promote or hamper the development of obesity-associated insulin resistance and type 2 diabetes.

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Section: Vldl/vldlrmentioning

confidence: 99%

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

Dahik

Frisdal

Goff

2020

IJMS

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“…Several molecular mechanisms of the role of macrophages during the long-term process of atherogenesis have been elucidated [8]. We recently showed that the proportion of metabolically normally stimulated macrophages in human adipose tissue is positively related to body mass index (BMI) [9], age (differently in men and women) [10], and is very closely positively related to non-high-density lipoprotein HDL) cholesterol concentration [11]. On the other hand, the properties and behavior of normally stimulated proinflammatory macrophages in adipose tissue (referred to as M1) are not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the properties and behavior of normally stimulated proinflammatory macrophages in adipose tissue (referred to as M1) are not yet fully understood. The common cause of the very close correlation of proatherogenic lipoprotein concentrations to polarization of adipose tissue macrophages [11] might be due to the mutual effect of diet on both parameters. Next, fatty acids (FAs) in phospholipids of adipose tissue cell membranes (probably the best parameter to document long-term saturated and unsaturated FA consumption) were analyzed and correlated to the proportion of proinflammatory adipose tissue macrophages.…”

Section: Introductionmentioning

confidence: 99%

Polarization of Macrophages in Human Adipose Tissue is Related to the Fatty Acid Spectrum in Membrane Phospholipids

et al. 2019

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Residential macrophages in adipose tissue play a pivotal role in the development of inflammation not only within this tissue, but also affect the proinflammatory status of the whole body. Data on human adipose tissue inflammation and the role of macrophages are rather scarce. We previously documented that the proportion of proinflammatory macrophages in human adipose tissue correlates closely with non-HDL cholesterol concentrations. We hypothesized that this is due to the identical influence of diet on both parameters and decided to analyze the fatty acid spectrum in cell membrane phospholipids of the same individuals as a parameter of the diet consumed. Proinflammatory and anti-inflammatory macrophages were isolated from human adipose tissue (n = 43) and determined by flow cytometry as CD14+CD16+CD36high and CD14+CD16−CD163+, respectively. The spectrum of fatty acids in phospholipids in the cell membranes of specimens of the same adipose tissue was analyzed, and the proportion of proinflammatory macrophage increased with the proportions of palmitic and palmitoleic acids. Contrariwise, these macrophages decreased with increasing alpha-linolenic acid, total n-3 fatty acids, n-3/n-6 ratio, and eicosatetraenoic acid. A mirror picture was documented for the proportion of anti-inflammatory macrophages. The dietary score, obtained using a food frequency questionnaire, documented a positive relation to proinflammatory macrophages in individuals who consumed predominantly vegetable fat and fish, and individuals who consumed diets based on animal fat without fish and nut consumption. he present data support our hypothesis that macrophage polarization in human visceral adipose tissue is related to fatty acid metabolism, cell membrane composition, and diet consumed. It is suggested that fatty acid metabolism might participate also in inflammation and the risk of developing cardiovascular disease.

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“…It has been suggested in a recent study that non-HDL-C may be superior to CRP in determining future cardiovascular events in children and adolescents with type 1 diabetes [32]. In fact, one study has shown that non-HDL-C has a high correlation with proin ammatory macrophages in adipose tissue [33]. Moreover, in an experimental study on apolipoprotein E-de cient mice, non-HDL-C reduction was reported to have a positive effect on the development of atherosclerosis by inhibiting leucocyte transmigration [34].…”

Section: Discussionmentioning

confidence: 99%

The relationship between non-HDL cholesterol and coronary collateral circulation

Yıldırım¹,

Se²,

Argan³

et al. 2020

Preprint

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Objective Non high density lipoprotein cholesterol (non HDL-C) covers all aterojenic lipoproteins and correlates with C reactive protein (CRP) which is reliable marker of inflammation. CRP is related to poor angiographic coronary collateral circulation (CCC). We aimed to show whether non HDL-C is associated with CCC.Methods Patients who underwent coronary angiography for stable coronary artery disease and at least one epicardial coronary artery occluded in the proximal or middle region were included in the study. Accrording to the Rentrop scoring system Rentrop 0 and 1 were considered to be poor CCC, and Rentrop 2 and 3 were considered to be good CCC. Non-HDL-C was calculated by subtracting HDL-C from total cholesterol (TC).Results 84 patients were included in the study. While 44 patients (52%) had good CCC, 40 patients (48%) had poor CCC. TC was found to be higher in the poor CCC group than in the good CCC group (224.3 ± 35.6 vs 179.2 ± 25.5 p = 0.000). HDL-C levels were found to be lower in the poor CCC group than in the good CCC group (37.3 ± 9.8 vs 44.1 ± 8.6 p = 0.001). Non-HDL-C cholesterol levels were higher in the group with poor CCC (185.7 ± 39.2 vs 132.8 ± 28.1 p = 0.000). CRP levels were found to be higher in the poor CCC group (3.73 ± 2.5 vs 1.67 ± 1.4 p = 0,000).Conclusion Non-HDL-C is independent predictors of poor CCC.

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The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue

Cited by 23 publications

References 29 publications

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

Polarization of Macrophages in Human Adipose Tissue is Related to the Fatty Acid Spectrum in Membrane Phospholipids

The relationship between non-HDL cholesterol and coronary collateral circulation

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