The intensive care nurse is responsible for caring patients with complex and life-threatening problems. The reasons such as the multiple problems who caring in the intensive care unit, the high caring requirements and the lack of care personnel can affect the ethical sensitivities, job motivations and hopelessness of the intensive care nurses. Therefore, this study was planned to determine the relationship between moral sensitivity, work motivation and hopelessness in nurses working in intensive care unit. Material and Method: This descriptive study was conducted between the date March 2019-May 2019 with the nurses working in the intensive care unit of a state hospital. Of the 75 nurses' data were collected at the time that study was conducted. "Descriptive Prosperities Information Form", "Moral Sensitivity Scale", "Nurses Job Motivation Scale" and "Beck Hopelessness Scale" were used as data collection tools. Results: 57.3% of intensive care nurses were male, 77.3% of them were undergraduate and average working year in nursing was found as 8.80±4.39. The mean score of the nurses' job motivation scale was 56.79±7.42, the mean of hopelessness scale was 8.92±4.74 and the mean score of moral sensitivity scale was 89.35±17.30. A statistically significant relationship was found between the working years of the nurses and their hopelessness (p=0.032) and work motivations (p=0.037). In our study, there was a statistically significant relationship between the levels of hopelessness and job motivations of nurses (r=-0.488, p<0.001). There was a statistically significant relationship between the moral sensitivities and job motivations of the nurses participated to the study (r=-0.278, p=0.033). Conclusion: According to our study results, it was found that nurses working time in intensive care unit had an effect on their job motivation and hopelessness level and it was found that that their moral sensitivities affect their job motivations.