The Relationship Between Obesity and Craniofacial Structure in Obstructive Sleep Apnea

Ferguson, Kathleen A.; Ono, Takashi; Lowe, Alan A.; Ryan, C. Frank; Fleetham, John A.

doi:10.1378/chest.108.2.375

Cited by 240 publications

(163 citation statements)

References 22 publications

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“…Upper airway MRI has shown excess fat deposition in the soft palate, tongue, and surrounding collapsible segments of the pharynx in patients with OSA compared with weight-matched controls (36). In this study, the prevalence of obesity was 90%, and AHI correlated significantly with BMI (r s Z0.50, PZ0.026; nZ20), confirming that obesity can be an aggravating factor for OSA (18,35). Hypertension was present in 71.4% of our population, whereas in other series it varies from 18 to 60% among patients with acromegaly (37).…”

Section: Discussionsupporting

confidence: 73%

“…This relationship between obesity and OSA is thought to be secondary to variations in neck circumference related to the degree of fat deposition in the neck (34). In fact, upper airway soft tissue structures increase in size with increasing obesity (35). Upper airway MRI has shown excess fat deposition in the soft palate, tongue, and surrounding collapsible segments of the pharynx in patients with OSA compared with weight-matched controls (36).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging.

Haute

Taboada

Corrêa

et al. 2008

European Journal of Endocrinology

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Objectives: To determine the prevalence of sleep apnea (SA) and SA syndrome (SAS) in patients with acromegaly and correlate SA with clinical, laboratory, and cephalometric parameters. Design and methods: Prospective and cross-sectional study of 24 patients with active acromegaly evaluated by clinical and laboratory (GH, IGF-I) parameters, polysomnography and magnetic resonance imaging (MRI) of the pharynx. Results: Out of 24 patients, 21 had SA (87.5%), of which 20 (95.3%) had the predominant obstructive type. Median age of these 21 patients was 54 years (range 23-75) and median estimated disease duration was 60 months (range 24-300). The frequency in SA patients of impaired glucose tolerance, diabetes mellitus (DM), and hypertension was 19, 33.3, and 71.4% respectively. Goiter was found in 10 patients (47.6%) and obesity in 18 (90%). Median GH level was 14 mg/l (1.4-198) and median %IGF-I (percentage above the upper limit of normal range of IGF-I) was 181% (K31.6 to 571.2). The prevalence of SAS was 52.4%. Apnea-hypopnea index (AHI) correlated significantly with age, waist circumference, body mass index, and hypopharynx area. The AHI was significantly higher in patients with hypertension and DM. Conclusions: The prevalence of SA and SAS in acromegaly was similar to the one previously described in other series. Age was a significant risk factor, and hypertension and DM were significantly associated complications of SA. Obesity was also significantly related to SA, as a risk factor, a complication or both. Overall, cephalometric parameters by MRI did not correlate with SA.European Journal of Endocrinology 158 459-465

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging.

Haute

Taboada

Corrêa

et al. 2008

European Journal of Endocrinology

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“…The pathogenesis of OSAHS has not been fully defined because of its multifactorial trait. This process is affected by the interaction of many positive and negative factors, such as obesity [1,2], tongue shape [3], tongue volume/oral cavity volume ratio [4], muscular hypotonia of upper airway [5,6], and neck circumference [7,8].…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of the Combination of Body Weight and Minimal Pharyngeal Cross-sectional Area in Assessing Obstructive Sleep Apnea

Hei¹,

Qin²,

Li³

2017

J Sleep Disord Ther

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Objectives: The study aims to evaluate the predictive value of a comprehensive index composed of simple biometric parameters in predicting apnea hypopnea index. Subjects and Methods:Ninety-four adult patients with obstructive sleep apnea-hypopnea syndrome were retrospectively reviewed. Pharyngeal axial-computed tomography and polysomnography were applied before surgery. Minimal pharyngeal cross-sectional area, sleep-associated monitoring indices including apnea hypopnea index, and biometric characteristics including body weight were all recorded. Correlations between these parameters were analyzed using correlation and multiple linear regression analyses.Results: Apnea hypopnea index was significantly correlated with minimal pharyngeal cross-sectional area (r=-0.390) and body weight (r=0.553). A notably higher correlation coefficient (r=0.681) was found between apnea hypopnea index and a new comprehensive index composed of minimal pharyngeal cross-sectional area and body weight data. Conclusion:Apnea hypopnea index might be largely influenced by a combined effect of minimal pharyngeal cross-sectional area and body weight. The new comprehensive parameter combining minimal pharyngeal crosssectional area and body weight is an effective indicator for the evaluation of obstructive sleep apnea.

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“…O palato mole alongado também foi um dos achados em outro estudo que avaliou indivíduos com SAOS e com circunferência cervical superior a 42 cm (63) .…”

Section: Palato Moleunclassified

“…Essa alteração da morfologia da VAS superior nos pacientes com SAOS também foi descrita por outros autores (34,41) . Li et al (41) O achado de palato mole espesso e redução do espaço aéreo retropalatal nos pacientes com SAOS também já foi descrito na literatura (12,39,63) . Considerou-se que o espessamento do palato mole poderia estar relacionado ao maior depósito de gordura nesta estrutura e ao edema relacionado à vibração (5) .…”

Section: Comparação Entre As Medidas Da Faringe Do Grupo Controle E Dunclassified

Avaliação da faringe de pacientes portadores de apneia obstrutiva do sono, por meio da tomografia computadorizada multislice obtida em vigília e durante o sono

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The Relationship Between Obesity and Craniofacial Structure in Obstructive Sleep Apnea

Cited by 240 publications

References 22 publications

Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging.

Prevalence of sleep apnea and metabolic abnormalities in patients with acromegaly and analysis of cephalometric parameters by magnetic resonance imaging.

Predictive Value of the Combination of Body Weight and Minimal Pharyngeal Cross-sectional Area in Assessing Obstructive Sleep Apnea

Avaliação da faringe de pacientes portadores de apneia obstrutiva do sono, por meio da tomografia computadorizada multislice obtida em vigília e durante o sono

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