The Relationship Between Overnight Plasma Growth Hormone Profiles and Nocturnal Urinary Growth Hormone Excretion

Stirling, Heather; Seth, John; Sturgeon, Catharine M.; Barnes, SC; Kelnar, Christopher J. H.

doi:10.1203/00006450-199305001-00223

Cited by 2 publications

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“…Preliminary studies have shown that this u-GH assay was applicable to physiological and pathological conditions (Torresani & Dinesen, 1991;Georges et al, 1993) and that there was a good correlation between overnight serum profiles and u-GH excretion (Stirling et al, 1993). As u-GH measurements were reproducible between laboratories, this assay may offer a valuable tool for comparisons of patient groups from different Centres.…”

Section: Discussionmentioning

confidence: 90%

The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non‐obese and obese children

Bona

Petri²,

Rapa³

et al. 1999

Clinical Endocrinology

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This study provides reference values for u-GH in normally growing non-obese and obese children, analysing the impact of gender, puberty and body mass on this parameter. In agreement with previous studies, which demonstrate blunted GH-responses to provocative stimuli and reduced nocturnal GH concentration, obese children have significantly lower u-GH levels than age-matched normal weight children, both before and during puberty.

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Section: Discussionmentioning

confidence: 90%

The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non‐obese and obese children

Bona

Petri²,

Rapa³

et al. 1999

Clinical Endocrinology

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show abstract

“…[9], but, interestingly, these authors only rarely encountered a value below their cutoff value for differentiating normal children from those with GH deficiency [personal comraun.]. Previous studies at our centre using the Novoclone uGH assay have shown that timed overnight uGHc reflected nocturnal plasma GH profiles [13]. These studies have also provided a cutoff value of around 9 ng/l [personal commun.]…”

Section: Discussionmentioning

confidence: 99%

Short-Term Changes in Urinary Growth Hormone Excretion and Lower Leg Length in Healthy Children

Ahmed

Barnes²,

Wallace³

et al. 1997

Horm Res

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To investigate any association between changes in lower leg length (LLL) and urinary growth hormone (uGH) excretion, 4 prepubertal children supplied daily 12-hour overnight urine samples and had daily knemometry performed for 4 weeks. The mean daily and weekly LLL velocity (LLLV) of the group was 0.08 mm/day (95% CI 0.01-0.18) and 0.52 mm/week (range 0.38-0.78), respectively. The mean uGH excretion was 8.9 ng/l (CI 3.7-13.3), and the mean intrasubject coefficient of variation of uGH was 55% (range 32-93). The tallest subject who also had the highest LLLV excreted the least amount of uGH (mean 3.7 ng/l, CI 2.9-4.5). No temporal relationship was evident between daily uGH excretion and LLL changes. There was no evidence of any association between amount of uGH excreted and LLLV. There remains some doubt on the usefulness of uGH measurement as the sole predictor of normal GH production.

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The Relationship Between Overnight Plasma Growth Hormone Profiles and Nocturnal Urinary Growth Hormone Excretion

Cited by 2 publications

References 0 publications

The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non‐obese and obese children

The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non‐obese and obese children

Short-Term Changes in Urinary Growth Hormone Excretion and Lower Leg Length in Healthy Children

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