The relationship between periodontal status and rheumatoid arthritis – systematic review

Samborska-Mazur, Joanna; Sikorska, Dorota; Wyganowska‐Świątkowska, Marzena

doi:10.5114/reum.2020.98436

Cited by 8 publications

(5 citation statements)

References 60 publications

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“…However, all samples received similar freezing and thawing cycles. Excessive complement activation has been associated also with several diseases and pathologies whose association with periodontitis has been suggested, such as Alzheimer's disease, 30 rheumatoid arthritis, 31 AMD, 32 and lung diseases, 33 involving dysregulations of inflammatory pathways. Since the present study has a cross‐sectional design, conclusions of causality cannot be drawn.…”

Section: Discussionmentioning

confidence: 99%

Common complement factor H polymorphisms are linked with periodontitis in elderly patients

Salminen

Pietiäinen

Paju

et al. 2022

Journal of Periodontology

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Background In our recent genome‐wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP‐8) concentration and the release of MMP‐8 from neutrophils. As MMP‐8 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of S100A8/A9/A12, MMP8, and CFH in periodontitis. In addition, we studied whether polymorphisms of these genes affect the concentrations of S100A8, S100A12, MMP‐8, or complement activation marker in saliva. Methods We genotyped four single‐nucleotide polymorphisms (SNPs, rs1560833 in S100A8/A9/A12, rs11225395 in MMP8, rs800292 in CFH, and rs1061170 in CFH) and measured salivary concentrations of S100A8, S100A12, MMP‐8, and terminal complement complex (TCC) in the Parogene cohort (n = 508). The cohort was composed of patients with an indication to coronary angiography and all underwent a clinical and radiographic oral examination. Results CFH polymorphisms rs800292 and rs1061170 were associated with periodontal parameters. None of the polymorphisms showed association with salivary proteins. However, salivary concentrations of S100A8, S100A12, MMP‐8, and TCC were strongly associated with the number of periodontal pockets and alveolar bone loss. Conclusion Interestingly, genetic variants of CFH, MMP8, and S100A8/A9/A12 gene regions did not affect salivary levels of measured proteins. However, saliva levels of S100A8, S100A12, MMP‐8, and TCC, and CFH polymorphisms were associated with clinical and radiographic signs of periodontitis. Our study further supports the observations that any dysregulation of complement may increase the risk of inflammatory disorders, such as periodontitis.

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Section: Discussionmentioning

confidence: 99%

Common complement factor H polymorphisms are linked with periodontitis in elderly patients

Salminen

Pietiäinen

Paju

et al. 2022

Journal of Periodontology

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“…Scientific evidence about the RA-periodontitis association mentions an epidemiological relationship, even with the methodological limitations these studies present [11,12]. By contrast, other studies suggest a clinical correlation arising from etiopathogenesis [13], and other studies refer to the possibility of a reciprocal relationship [14,15].…”

Section: Introductionmentioning

confidence: 94%

The Effect of Periodontal Treatment on Clinical and Biological Indicators, Quality of Life, and Oral Health in Rheumatoid Arthritis Patients: A Quasi-Experimental Study

Posada-López

Botero

Pineda-Tamayo³

et al. 2022

IJERPH

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Non-surgical periodontal therapy (NSPT) has been shown to have systemic effects. It has been suggested that, similar to rheumatoid arthritis (RA), periodontitis (PD) has an impact on general health, in terms of psychological, physical, and social aspects. This study determines the effect of periodontal treatment in RA activity, health-related quality of life, and oral health self-perception before and after periodontal treatment in RA patients. A quasi-experimental, prospective, non-randomized study was conducted, and 52 patients were included in the study. Periodontal parameters and the instruments disease activity score-28 (DAS-28), SF-36, and OHIP-14 were measured at baseline and at 3 months after NSPT. All differences were statistically assessed. The study protocol was registered in Clinical Trials (NCT04658615). No statistically significant differences were found in the scores of DAS-28 before and after the intervention in the group with PD and reduced periodontium. When the effect of periodontal treatment was analyzed in the group of 29 patients who were followed up, it was found that there were statistically significant differences before and after in variables such as psychological distress, emotional role, and mental health, which indicates an improvement in the scores of these variables. NSPT influenced the health-related quality of life measured with SF-36 and OHIP-14 in patients with RA. In conclusion, NSPT has an effect on self-reported quality of life and health indicators more than the RA activity as measured with DAS-28. However, the clinical effect of periodontal treatment in RA patients provides important data to support periodontal care in patients.

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“…We read with great interest the article entitled "The re la tionship between periodontal status and rheumatoid ar thritis -systematic review", recently published in Reuma tologia [1].…”

Section: Dear Editormentioning

confidence: 99%

Periodontitis and rheumatoid arthritis: three messages from published literature to clinical practice

Manzo¹,

Kéchida

2020

Reumatologia

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We read with great interest the article entitled “The relationship between periodontal status and rheumatoid arthritis – systematic review”, recently published in Reumatologia [1]. <br /> This relationship, suggested for more than 20 years [2], has increasingly been reported in the last years, and two recent meta-analyses confirmed a statistically significant association between rheumatoid arthritis (RA) and periodontitis (PD) compared to healthy controls [3, 4].

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The relationship between periodontal status and rheumatoid arthritis – systematic review

Cited by 8 publications

References 60 publications

Common complement factor H polymorphisms are linked with periodontitis in elderly patients

Common complement factor H polymorphisms are linked with periodontitis in elderly patients

The Effect of Periodontal Treatment on Clinical and Biological Indicators, Quality of Life, and Oral Health in Rheumatoid Arthritis Patients: A Quasi-Experimental Study

Periodontitis and rheumatoid arthritis: three messages from published literature to clinical practice

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