The relationship between plasma fatty acids and risk factors for insulin resistance in men

Serum fatty acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty acid profiles

“…It is well established that high fat diets contribute to the development of IR [117,196]; however, not all fatty acids (FAs) influence IR equally. For example, high circulating levels of saturated fatty acids (SFAs) and n--6 polyunsaturated fatty acids (PUFAs) are associated with elevated fasting levels of insulin and glucose [171,223,224]. Interestingly, these same FA were reported to be more abundant in diabetic patients compared to healthy individuals [224].…”