The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease

Hong, Sae‐Yong; Yang, Dong-Ho; Chang, Sung-Keun

doi:10.1016/s1051-2276(98)90035-8

Cited by 35 publications

(17 citation statements)

References 21 publications

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“…It is characteristic of chronic renal insufficiency, end-stage renal disease, and in RTR in both American 11-13 and Korean patients. 14, 15 The etiology of hyperhomocysteinemia commonly observed in patients with chronic renal disease remains unknown. Derangement of intrarenal homocysteine metabolism, 16 and/or uremia-induced extrarenal defects in homocysteine metabolism, 17 may contribute to this mild hyperhomocysteinemia.…”

Section: Discussionmentioning

confidence: 99%

Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients

Han

Dwyer

Selhub

et al. 2000

Journal of Renal Nutrition

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Section: Discussionmentioning

confidence: 99%

Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients

Han

Dwyer

Selhub

et al. 2000

Journal of Renal Nutrition

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“…To measure amino acids, plasma free amino acids (PFAAs), which abundantly circulate as a medium linking all organ systems, would be the most favorable target because their profiles have been known to be influenced by metabolic variations in specific organ systems induced by specific diseases [18], [19], [20], [21]. Additionally, plasma samples can be collected easily from patients.…”

Section: Introductionmentioning

confidence: 99%

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

et al. 2011

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BackgroundRecently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs) is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases, including cancers. Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection.Methods and FindingsPlasma samples were collected from approximately 200 patients from multiple institutes, each diagnosed with one of the following five types of cancer: lung, gastric, colorectal, breast, or prostate cancer. Patients were compared to gender- and age- matched controls also used in this study. The PFAA levels were measured using high-performance liquid chromatography (HPLC)–electrospray ionization (ESI)–mass spectrometry (MS). Univariate analysis revealed significant differences in the PFAA profiles between the controls and the patients with any of the five types of cancer listed above, even those with asymptomatic early-stage disease. Furthermore, multivariate analysis clearly discriminated the cancer patients from the controls in terms of the area under the receiver-operator characteristics curve (AUC of ROC >0.75 for each cancer), regardless of cancer stage. Because this study was designed as case-control study, further investigations, including model construction and validation using cohorts with larger sample sizes, are necessary to determine the usefulness of PFAA profiling.ConclusionsThese findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a relatively simple plasma assay and imposes a lower physical burden on subjects when compared to existing screening methods.

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“…Many studies have shown that alterations in human aminograms can be caused by diseases. For example, liver failure [15], [16], renal failure [17], cancer [18], [19], diabetes [20], [21], and cardiovascular disorders [22] have been reported to alter aminograms. As liver fibrosis progresses, Fisher's ratio, which is the ratio of branched-chain amino acids to aromatic amino acids, has been shown to be elevated [23], [24], [25].…”

Section: Introductionmentioning

confidence: 99%

Characteristic Metabolism of Free Amino Acids in Cetacean Plasma: Cluster Analysis and Comparison with Mice

et al. 2010

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From an evolutionary perspective, the ancestors of cetaceans first lived in terrestrial environments prior to adapting to aquatic environments. Whereas anatomical and morphological adaptations to aquatic environments have been well studied, few studies have focused on physiological changes. We focused on plasma amino acid concentrations (aminograms) since they show distinct patterns under various physiological conditions. Plasma and urine aminograms were obtained from bottlenose dolphins, pacific white-sided dolphins, Risso's dolphins, false-killer whales and C57BL/6J and ICR mice. Hierarchical cluster analyses were employed to uncover a multitude of amino acid relationships among different species, which can help us understand the complex interrelations comprising metabolic adaptations. The cetacean aminograms formed a cluster that was markedly distinguishable from the mouse cluster, indicating that cetaceans and terrestrial mammals have quite different metabolic machinery for amino acids. Levels of carnosine and 3-methylhistidine, both of which are antioxidants, were substantially higher in cetaceans. Urea was markedly elevated in cetaceans, whereas the level of urea cycle-related amino acids was lower. Because diving mammals must cope with high rates of reactive oxygen species generation due to alterations in apnea/reoxygenation and ischemia-reperfusion processes, high concentrations of antioxidative amino acids are advantageous. Moreover, shifting the set point of urea cycle may be an adaption used for body water conservation in the hyperosmotic sea water environment, because urea functions as a major blood osmolyte. Furthermore, since dolphins are kept in many aquariums for observation, the evaluation of these aminograms may provide useful diagnostic indices for the assessment of cetacean health in artificial environments in the future.

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The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease

Cited by 35 publications

References 21 publications

Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients

Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

Characteristic Metabolism of Free Amino Acids in Cetacean Plasma: Cluster Analysis and Comparison with Mice

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