The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women

Bucciarelli, Paolo; Martini, Giuseppe; Martinelli, Ida; Ceccarelli, Elena; Gennari, Luigi; Bader, R; Valenti, Roberto; Franci, Beatrice; Nuti, Ranuccio; Mannucci, Pier Mannuccio

doi:10.1016/j.ejim.2010.03.017

Cited by 41 publications

(30 citation statements)

References 40 publications

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“…Our results indicated that Hcy was associated with the risk of PO, which was in accordance with the previous clinical reports [13, 17, 27, 44, 45] and also a recent meta-analysis [46]. Although inverse [47], mixed [48], and no associations [31, 49] between BMD and Hcy have also been reported, as Gerdhem et al [47] reported, this controversial association between Hcy and BMD could be explained partly by the inability of the BMD measurement to reflect the status of bone metabolism. After all, all the results suggest the import role of Hcy in bone metabolism and the development of PO.…”

Section: Discussionsupporting

confidence: 92%

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

et al. 2016

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Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.

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Section: Discussionsupporting

confidence: 92%

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

et al. 2016

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“…Acceptable could be also explanation of Bucciarelli et al [27] that the strength of the association between Hcy and BMD is mild, and cannot be detected by studies with a relatively small sample size.…”

Section: Discussionmentioning

confidence: 91%

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Rumbak

Žižić

Sokolić

et al. 2011

Arch Gynecol Obstet

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“…Pooled analysis showed no association between serum/plasma vitamin B 12 levels and BMD in women; FN: β = 0.00, 95% CI: −0.13 to 0.14, I 2 = 0%, P = 0.40 [9, 37, 40]; LS: β = −2.25, 95% CI: −7.98 to 3.49, I 2 = 99.5%, P < 0.0001 [9, 37, 39, 40]; total hip β = −2.23, 95% CI: −10.38 to 5.92, I 2 = 97.7%, and P = 0.0001 [33, 37, 39, 40]. The studies that could not be included in the meta-analyses showed diverse results; in six out of eight studies low serum/plasma vitamin B 12 was significantly associated with low BMD at at least one site [6, 7, 11, 32, 35, 38].…”

Section: Resultsmentioning

confidence: 99%

“…Pooled analyses showed no association between serum/plasma homocysteine levels and BMD in women; FN: β = −0.01, 95% CI: −0.04 to 0.02, I 2 = 31.5%, P = 0.21 [9, 27, 37, 40]; LS: β = −0.01, 95% CI: −0.08 to 0.05, I 2 = 98.4%, P < 0.0001 [9, 27, 37, 39, 40]; total hip: β = −0.03, 95% CI: −0.08 to 0.02, I 2 = 99.9%, P < 0.0001 [10, 27, 33, 37, 39, 40]. The studies that could not be pooled showed diverse results.…”

Section: Resultsmentioning

confidence: 99%

Vitamin B₁₂, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses

Wijngaarden

Doets

Szczecinska

et al. 2013

Journal of Nutrition and Metabolism

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Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with fractures and bone mineral density (BMD). Twenty-seven eligible cross-sectional (n = 14) and prospective (n = 13) observational studies and one RCT were identified. Meta-analysis on four prospective studies including 7475 people showed a modest decrease in fracture risk of 4% per 50 pmol/L increase in vitamin B12 levels, which was borderline significant (RR = 0.96, 95% CI = 0.92 to 1.00). Meta-analysis of eight studies including 11511 people showed an increased fracture risk of 4% per μmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07). We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association. Meta-analyses regarding vitamin B12, folate and homocysteine levels, and BMD were possible in female populations only and showed no associations. Results from studies regarding BMD that could not be included in the meta-analyses were not univocal.

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The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women

Cited by 41 publications

References 40 publications

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Vitamin B₁₂, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses

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The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women

Cited by 41 publications

References 40 publications

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses

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Vitamin B₁₂, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses