The Relationship Between Polymorphisms in the Endothelial Cell Nitric Oxide Synthase Gene and the Platelet GPIIIa Gene With Myocardial Infarction and Venous Thromboembolism in African Americans

Hooper, W. Craig; Lally, Cathy; Austin, Harland; Benson, Jane M.; Dilley, Anne; Wenger, Nanette K.; Whitsett, Carolyn; Rawlins, Peggy; Evatt, Bruce L.

doi:10.1378/chest.116.4.880

Cited by 84 publications

(65 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The a allele was found more frequently in African-Americans (27-31%) than in Caucasians (16-18%) or Japanese (10-13%). 9,26,[34][35][36][37] Once again the frequency of a allele in Venezuelan subjects most closely compared to that of the Caucasians, since it was found in 18% of the Venezuelan subjects studied.…”

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 84%

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

et al. 2004

View full text Add to dashboard Cite

Mutations in the endothelial nitric oxide synthase (eNOS) gene may be associated with abnormal nitric oxide (NO) production and cardiovascular diseases. In this study, we investigated the prevalence of two eNOS polymorphisms, the Glu298Asp variant on exon 7, and the 4a/b variable number of tandem repeats (VNTR) on intron 4, and their association with blood pressure (BP), NO production, salt sensitivity and cardiovascular risk factors in healthy Venezuelans. The prevalence of both polymorphisms in Venezuelans was comparable to that described for Caucasians, but significantly different from that known for African-Americans and Japanese. The 4a/b genotype was associated with reduced levels of NO metabolites (25% decrease), larger BP lowering in response to salt restriction (9.0 vs 4.8 mmHg, Po0.05), greater prevalence of salt sensitivity (39% in 4a/b and 27% in 4b/b; Po0.05) and with higher LDL-cholesterol levels. The Glu298T polymorphism did not affect NO production, nor it was associated with salt sensitivity. Glu298Asp polymorphism was positively associated with higher weight, triglycerides and LDL-cholesterol. Neither polymorphism was associated with changes in fasting or postload serum glucose, BP, obesity and albuminuria. In conclusion, the prevalence of eNOS polymorphisms is strongly determined by ethnic factors. The 4a/b gene polymorphism could be a genetic susceptibility factor for the BP response to salt intake and for the genetic control of NO production. The reduced NO production in subjects with the 4a/b genotype may be responsible for the increased sensitivity of their BP to salt.

show abstract

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 84%

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The higher prevalence of PE among Black-American women in our study may reflect health disparities in VTE as well, including the social factors of access to care and delayed identification of DVT. Alternatively, the biology of VTE among Blacks may increase the proportion [29][30][31][32][33][34] our findings suggest that a genetic component may exist in the etiology of VTE among Blacks. In support of this hypothesis, the plasma levels of several procoagulant and anticoagulant factors both vary by race [35][36][37][38] and exhibit substantial heritability [39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross‐sectional study

et al. 2010

View full text Add to dashboard Cite

When compared with Whites, Black-Americans may have a 40% higher incidence venous thromboembolism (VTE) incidence. However, whether other VTE characteristics and risk factors vary by race is uncertain. To compare demographic and baseline characteristics among White-and Black-Americans with VTE, we used data prospectively collected from consecutive consenting adults enrolled in seven Centers for Disease Control (CDC) Thrombosis and Hemostasis Centers from August 2003 to March 2009. These characteristics were compared among Whites (n 5 2002) and Blacks (n 5 395) with objectively diagnosed VTE, both overall, and by age and gender. When compared with Whites, Blacks had a significantly higher proportion with pulmonary embolism (PE), including idiopathic PE among Black women, and a significantly higher proportion of Blacks were women. Blacks had a significantly higher mean BMI and a significantly lower proportion with recent surgery, trauma or infection, family history of VTE, and documented thrombophilia (solely from reduced factor V Leiden and prothrombin G20210A prevalence). Conversely, Blacks had a significantly higher proportion with hypertension, diabetes mellitus, chronic renal disease and dialysis, HIV, and sickle cell disease. When compared with White women, Black women had a significantly lower proportion with recent oral contraceptive use or hormone therapy. We conclude that Whites and Blacks differ significantly regarding demographic and baseline characteristics that may be risk factors for VTE. The prevalence of transient VTE risk factors and idiopathic VTE among Blacks appears to be lower and higher, respectively, suggesting that heritability may be important in the etiology of VTE among Black-Americans. Am. J. Hematol. 85:467-471, 2010. V V C 2010 Wiley-Liss, Inc. IntroductionMost epidemiologic studies of venous thromboembolism (VTE) risk factors have been conducted within White-American and -European populations [1][2][3][4]. However, when compared with Whites, Black-Americans appear to have a higher risk for [5,6] and incidence of VTE [7][8][9][10]. Two single-nucleotide polymorphisms, factor V Leiden (G1691A) and prothrombin G20210A, have been identified as risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) in Europeans and White-Americans, [11][12][13][14][15][16] but not Black-Americans [6,17,18]. We hypothesized that the apparent higher VTE incidence among Blacks might be due to an increased prevalence of known VTE risk factors. To test this hypothesis, we compared demographic and baseline clinical characteristics from White-and Black-Americans with objectively diagnosed VTE who were seen in one of the seven CDC Thrombosis and Hemostasis Research and Prevention Network centers.

show abstract

“…The eNOS gene could be a candidate gene for the development of atherosclerosis, and it has been extensively studied in this condition. The Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the eNOS gene are the most studied polymorphisms of this gene in coronary atherosclerosis, thrombosis, and other thrombotic/ischemic conditions (10)(11)(12)(13)(14)(15)(16). Asp 298 and/or 4a polymorphisms have been found to be associated with angiographic evidence of coronary artery disease and myocardial infarction (10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…The Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 are the most studied polymorphisms of the eNOS gene under conditions in which endothelial dysfunction plays a key pathogenic role, such as in coronary atherosclerosis, thrombosis, and other ischemic/thrombotic conditions (10)(11)(12)(13)(14)(15)(16). Interestingly, a functional role has been postulated for both polymorphisms (17)(18)(19)(20).…”

mentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis

Salvarani¹,

Casali²,

Nicoli³

et al. 2003

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To examine potential associations of the Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of giant cell arteritis (GCA), particularly in patients with versus those without ischemic complications.Methods. Ninety-one consecutive patients with biopsy-proven GCA, who were residents of Reggio Emilia, Italy, and 133 population-based controls from the same geographic area were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for eNOS polymorphisms in exon 7 and intron 4. The patients were separated into 2 subgroups according to the presence or absence of ischemic complications (visual loss and/or jaw claudication and/or aortic arch syndrome).Results. The distribution of the Glu/Asp 298 genotype differed significantly between GCA patients and controls (corrected P [P corr ] ‫؍‬ 0.003). Carriers of the Asp 298 allele (Asp/Asp or Glu/Asp) were significantly more frequent among the GCA patients than among the controls (P corr ‫؍‬ 0.0002, odds ratio 3.3, 95% confidence interval 1.7-6.3). The distribution of the 4a/b genotype was similar in GCA patients and controls. No significant associations were found when GCA patients with and without ischemic complications were compared.Conclusion. Our findings show that the Glu/ Asp 298 polymorphism of the eNOS gene is associated with GCA susceptibility.

show abstract

The Relationship Between Polymorphisms in the Endothelial Cell Nitric Oxide Synthase Gene and the Platelet GPIIIa Gene With Myocardial Infarction and Venous Thromboembolism in African Americans

Cited by 84 publications

References 35 publications

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross‐sectional study

Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis

Contact Info

Product

Resources

About