The relationship between previous antimicrobial use, antimicrobial resistance and treatment outcome among Alaskans treated for<i>Helicobacter pylori</i>infection

Bruce, Michael G.; Bruden, Dana; Newbrough, Deidra; Hurlburt, Debby; Hennessy, Thomas W.; Morris, Julie; Reasonover, Alisa; Sacco, Frank; McMahon, Brian J.

doi:10.1002/ygh2.352

Cited by 5 publications

(4 citation statements)

References 43 publications

(88 reference statements)

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“…Furthermore, a high proportion of H. pylori isolates among Alaska Natives demonstrate resistance to common antimicrobials (71). High rates of treatment failure have been documented (72)(73)(74) (79). In Russia, H. pylori prevalence among an Indigenous circumpolar population (Chukotka males) was 77.0% (21,80).…”

Section: Discussionmentioning

confidence: 99%

Stomach Cancer Incidence and Mortality Trends among Circumpolar Nations

Simkin

Nash

Барчук

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Stomach cancer incidence and mortality rates are declining across circumpolar nations, but the burden may not be distributed equally across subpopulations, including Indigenous peoples. Our objective was to examine stomach cancer incidence and mortality trends across circumpolar populations. Methods: Cancer incidence and mortality data from 1999–2016 were obtained from the Canadian Cancer Registry, Canadian Vital Statistics, CDC WONDER, NORDCAN, Northwestern Russian cancer registries, and National Cancer Reports. The direct method was used to calculate 10-year rolling age-standardized incidence and mortality rates to the world (WHO 2000–2025) and 2011 Canadian standard populations. Standardized incidence rate ratios (SRR) were calculated. Data were stratified by sex, year, and region. U.S. data were broken down by race [White; American Indian/Alaska Native (AIAN)]. Race data were not available from non-U.S. cancer registries. Results: Most populations showed declining incidence and mortality rates over time. Incidence rates among Greenland males and females, Alaska AIAN males and females, and Northern Canadian both sexes were elevated compared with regional counterparts and remained stable. The largest male SRR was observed among Alaska AIAN versus Alaska Whites [SRR = 3.82; 95% confidence interval (95% CI), 2.71–5.37]. The largest female SRR was observed among Alaska AIAN versus Alaska Whites (SRR = 4.10; 95% CI, 2.62–6.43). Conclusions: Despite stomach cancer incidence and mortality rates declining overall, some northern and Indigenous populations experience elevated and stable incidence and mortality rates. Impact: There is a need to address disparities observed among circumpolar subpopulations. Given similarities in incidence, mortality, and risk factor prevalence across circumpolar regions, addressing disparities could benefit from coordinated international action.

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Section: Discussionmentioning

confidence: 99%

Stomach Cancer Incidence and Mortality Trends among Circumpolar Nations

Simkin

Nash

Барчук

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…13,14 Helicobacter pylori Data from Alaska have shown very high rates of H pylori antimicrobial resistance and treatment failure. 15 A study that evaluated reinfection with H pylori in AN people after successful treatment found that 22% of AN people in rural areas were reinfected by 2 years 5 and >35% by 12 years (unpublished data), a rate much higher than those reported in other populations in developed countries. Broad H pylori treatment across the population is associated with risks, including overall changes to the host microbiome, increased antimicrobial resistance, and possible immunologic changes.…”

Section: Esophagogastroduodenoscopy In Alaskamentioning

confidence: 97%

Combating Gastric Cancer in Alaska Native People: An Expert and Community Symposium

et al. 2020

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A laska Native (AN) people experience higher incidence of, and mortality from, gastric cancer compared to other US populations. 1,2 Compared to the general U.S. population, gastric cancer in AN people occurs at a younger age, is diagnosed at later stages, is more evenly distributed between the sexes, and more frequently shows signet-ring or diffuse histology. 3 It is known that the prevalence of Helicobacter pylori infection, a risk factor for gastric cancer, is high in AN people 4 ; however, high antimicrobial resistance combined with high reinfection rates in Alaska make treatment at the population level complex. 5 In addition, health issues in AN people are uniquely challenging because of the extremely remote locations of many residents. A multiagency workgroup hosted a symposium in Anchorage, Alaska, that brought internationally recognized experts and local leaders together to evaluate issues around gastric cancer in the AN population. The overall goal of this symposium was to identify the best strategies to combat gastric cancer in the AN population through prevention and early diagnosis. Symposium Framework To identify goals and actions that were scientifically sound, logistically realistic, and culturally acceptable, a symposium was hosted in Anchorage, Alaska, in July 2019. This symposium brought together voices from many viewpoints, included gastric cancer and H pylori experts, Alaskan health providers, AN community and tribal leaders, public health officials, and representatives from other North American indigenous populations. Overall, 57 people attended and contributed to this symposium. The symposium aimed to identify concrete actions and was designed to maximize discussion. Scientific presentations were kept to a minimum. Presenters were encouraged to present well-established conclusions and information that could be used to address gastric cancer in AN people. After the scientific presentations, the symposium was divided into small groups, and participants were asked to identify the main questions or challenges related to gastric cancer in AN people. On the second day, the group was divided into 2 sections; 1 focused on scientific data and investigations, and 1 focused on community priorities and cultural acceptability. The symposium ended with the 2 groups coming together to summarize findings. The overall goal of this symposium was not to create guidance but to evaluate existing data, identify knowledge gaps, and summarize actions that could improve gastric cancer diagnosis and survival.

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“…Hence, a con rmation test for the eradication of H. pylori is essential at the end of the course of H. pylori eradication therapy. The stool antigen test is an e cient and common tool for this purpose (7).…”

Section: Introductionmentioning

confidence: 99%

The evaluation of MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection

Negaresh

Safarzadeh

Fouladi

et al. 2023

Preprint

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Background Helicobacter pylori (H.pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix metalloproteinase-2 (MMP-2) to tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with a peptic ulcer that are sensitive or resistant to H. pylori treatment and compare them with healthy individuals. Methods In this study, 95 patients were included and divided into two groups sensitive (41 patients) and resistant to treatment (54 patients). The results were compared with a control group of twenty participants with normal endoscopy. After obtaining written informed consent, five ml of venous blood was taken to determine their serum MMP-2 and TIMP-1 levels using an enzyme-linked immunosorbent assay. Results In patients with H. pylori-induced peptic ulcers, the MMP-2/TIMP-1 ratio was significantly higher than those of the healthy controls (P < 0.05). MMP-2 level was associated with patients’ response to treatment (P < 0.05). The MMP-2/TIMP-1 ratio and the chance for refractory H. pylori-induced peptic ulcer disease were higher in patients with simultaneous gastric and duodenal ulcers (P < 0.05). Conclusion It seems that peptic ulcer disease caused by infection with H. pylori increases the MMP-2/TIMP-1 ratio in patients with peptic ulcers. However, it might not be a good predictor of refractory H. pylori-induced peptic ulcer disease.

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The relationship between previous antimicrobial use, antimicrobial resistance and treatment outcome among Alaskans treated forHelicobacter pyloriinfection

Cited by 5 publications

References 43 publications

Stomach Cancer Incidence and Mortality Trends among Circumpolar Nations

Stomach Cancer Incidence and Mortality Trends among Circumpolar Nations

Combating Gastric Cancer in Alaska Native People: An Expert and Community Symposium

The evaluation of MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection

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