The Relationship Between Primary Thyroid Lymphoma and Various Types of Thyroid Autoimmunity: A Retrospective Cohort Study of 498 Cases, Including 9 Cases with Graves' Disease

Suzuki, Nami; Watanabe, Natsuko; Noh, Jaeduk Yoshimura; Yoshimura, Ran; Mikura, Kentaro; Kinoshita, Aya; Suzuki, Atsushi; Mitsumatsu, Takako; Fukushita, Miho; Matsumoto, Masako; Yoshihara, Ai; Katoh, Ryohei; Sugino, Kiminori; Ito, Koichi

doi:10.1089/thy.2021.0613

Cited by 5 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compression symptoms were far more frequent in DLBCL compared to Maltomas, as follows: dysphagia 27% vs. 13%, cough 15% vs. 7%, dyspnoea 17% vs. 3%, hoarseness: 4.9% vs. 0%, respectively [34]. HT patients demonstrated a (x40-80) increased risk for developing PTL [2,35], especially Maltoma, whereas 78% of PTL patients had some evidence of HT subtype [1,[3][4][5]12,15,32,35]. Dysthyroidism is common in long standing HT, and was exceptionally reported in cases of ATC ([36] or MTT [36,37] and in iatrogenic cases [38].…”

Section: Discussionmentioning

confidence: 98%

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Marcy¹,

Bauduer

Thariat

et al. 2023

Current Oncology

View full text Add to dashboard Cite

A rapid growing cervical mass mobile while swallowing is the most common clinical presentation of severe thyroid malignancy. A 91-year-old female patient with a history of Hashimoto thyroiditis presented with clinical compressive neck symptoms. The patient had gastric Maltoma diagnosed that was surgically resected thirty years ago. A straightforward process was needed to reach full histological diagnosis and initiate prompt therapy. Ultrasound (US) showed a 67 mm hypoechoic left thyroid mass with reticulated pattern without signs of locoregional invasion. Percutaneous trans isthmic US-guided 18G core needle biopsy (CNB) disclosed diffuse large B cell lymphoma of the thyroid gland. FDG PET revealed two distinct thyroid and gastric foci (both SUVmax 39.1). Therapy was initiated rapidly to decrease clinical symptoms in this aggressive stage III primitive malignant thyroid lymphoma. The prognostic nomogram was calculated by using a seven-item scale, which disclosed a one-year overall survival rate of 52%. The patient underwent three R-CVP chemotherapy courses, then refused further treatment and died within five months. Real-time US-guided CNB approach led to rapid patient’s management that was tailored to patient’s characteristics. Transformation of Maltoma into diffuse large B cell lymphoma (DLBCL) into two body areas is deemed to be extremely rare.

show abstract

Section: Discussionmentioning

confidence: 98%

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Marcy¹,

Bauduer

Thariat

et al. 2023

Current Oncology

View full text Add to dashboard Cite

show abstract

“…T-cell lymphoma is extremely rare and has a relatively poor prognosis 6-8 . The risk of developing thyroid lymphoma is 67 times greater in patients with HT than those with colloid goiter 9 , and as high as 90% of subjects with PTL have a positive history of HT 10 , 11 . In our cohort, similar to the previously reported literature, the median age was 72.5 years (range: 50-83 years); seven of eight cases (85.7%) were females, with seven (85.7%) having a history of HT.…”

Section: Discussionmentioning

confidence: 99%

Prompt diagnosis and airway management for primary thyroid lymphoma with compromised upper airway: a single-institution case series

Zhang

Zhao

Dong

et al. 2023

Acta Otorhinolaryngol Ital

View full text Add to dashboard Cite

“…40 Compared with other extranodal DLBCLs, the Ann Arbor clinical stage of PTL is usually limited to the early stage, with most of them in stage I or II. 6,155 Therefore, PTL including thyroid DLBCL has a good prognosis. Modern chemotherapy and radiotherapy combined with rituximab have shown results in clinical treatment of PTL, and surgery is no longer the preferred treatment for PTL.…”

Section: Thyroid Glandmentioning

confidence: 99%

“…Primary thyroid lymphoma (PTL) accounts for 1%–5% of all thyroid malignancies, 1%–2% of extranodal DLBCLs, and about half of PTL is DLBCL 37,38,155 . The occurrence of PTL is closely related to Hashimoto's thyroiditis 155 , . Research on the molecular level of PTL is limited.…”

Section: Primary Extranodal Dlbcls Of Specific Anatomical Sitesmentioning

confidence: 99%

See 1 more Smart Citation

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Chen

et al. 2022

Aging and Cancer

View full text Add to dashboard Cite

Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and represents a heterogeneous entity. One‐third of DLBCL arises from extranodal organs and its prognosis often varies with regard to the sites involved. Molecular features are important to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Extranodal DLBCLs originated from the breast, skin, uterus, immune‐privileged sites such as the central nervous system and testes, often show a high proportion of non‐germinal center B‐cell‐like (non‐GCB) phenotypes, with a high frequency of MYD88/CD79B mutations. In contrast, extranodal DLBCLs originated from the thyroid gland and stomach show a relatively low proportion of non‐GCB phenotype, with a considerably excellent prognosis. Immunochemotherapy with rituximab is the standard of care in both nodal and extranodal DLBCLs. However, approximately 40% of the patients experience treatment failure. It is critical to optimize the treatment strategy, including radiotherapy, autologous stem cell transplantation and targeted therapy according to the clinical characteristics and molecular heterogeneity. In this review, we present an overview of the key molecular pathways, prognosis assessment and innovative therapies in primary extranodal DLBCLs.

show abstract

The Relationship Between Primary Thyroid Lymphoma and Various Types of Thyroid Autoimmunity: A Retrospective Cohort Study of 498 Cases, Including 9 Cases with Graves' Disease

Cited by 5 publications

References 25 publications

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient

Prompt diagnosis and airway management for primary thyroid lymphoma with compromised upper airway: a single-institution case series

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Contact Info

Product

Resources

About