Our results suggest that interventions targeting balance and unaffected upper limb function could be effective in rehabilitation to improve grooming performance in survivors of stroke. Implications for rehabilitation Balance and unaffected upper limb function have a strong effect on grooming independence in survivors of stroke. Balance is most influenced by affected lower limb function, and unaffected upper limb function is equally influenced by balance, visuospatial perception, and grip strength. Interventions targeting balance and unaffected upper limb function can improve grooming performance in survivors of stroke.