The relationship between psychological symptoms, lung function and quality of life in children and adolescents with non-cystic fibrosis bronchiectasis

Bahalı, Kayhan; Gedik, Ahmet Hakan; Bi̇lgi̇ç, Ayhan; Çakır, Erkan; Kahraman, Feyza Ustabaş; Osmanoğlu, Nurcan Keskin; Uzuner, Selçuk; Kılıçoğlu, Ali Güven

doi:10.1016/j.genhosppsych.2014.05.019

Cited by 24 publications

(25 citation statements)

References 17 publications

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“…Similarly, although psychiatric disorders such as anxiety and depression are related to worsened respiratory symptoms, increased health expenditure, and noncompliance with therapy in the patients with chronic pulmonary diseases, it may frequently be overlooked in daily practice 6,7. There are a limited number of studies on the prevalence of depression and anxiety in either pediatric or adult cases with bronchiectasis, which is a significant chronic pulmonary problem 8–10…”

Section: Introductionmentioning

confidence: 99%

Factors related to depression and anxiety in adults with bronchiectasis

Niksarlıoğlu

Özkan

Günlüoğlu

et al. 2016

NDT

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Introduction and backgroundPatients with chronic lung diseases frequently have depressive and anxiety symptoms, but there are very few studies looking at this in patients with bronchiectasis.AimThis study aimed to investigate depression and anxiety and related factors among patients with non-cystic fibrosis bronchiectasis.Patients and methodsThis was a prospective study of 133 patients with bronchiectasis. Patients with confirmed diagnosis of bronchiectasis with high-resolution computed tomography were enrolled in the study. Patients that were clinically stable in the previous 4 weeks were evaluated with the Hospital Depression and Anxiety scale. Symptoms, pulmonary function tests, and medical treatments were recorded.ResultsThe mean age of patients was 49.5±14.5 years (range, 18–77 years), and 81 (60.9%) patients were females. Twenty-eight (21.1%) patients had depression, and 53 (39.8%) had anxiety. Depression score was related to family situation (living with a partner), previous depression history and admission to an emergency department within the last year. Anxiety score was related to female gender, the family situation (living with a partner), previous depression history, and admission to an emergency department within the last year (P<0.05). Depression was positively correlated with hemoptysis, admission to an emergency department within the last year and living with a partner. Anxiety was positively correlated with education level, previous depression history, admission to an emergency department within the last year, and living with a partner.ConclusionPatients with non-cystic fibrosis bronchiectasis are at increased risk for depression and anxiety. Untreated and undetected depressive/anxiety symptoms may increase physical disability, morbidity, and health care utilization. It is important for clinicians to be aware of the presence of depression and anxiety in bronchiectasis.

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Section: Introductionmentioning

confidence: 99%

Factors related to depression and anxiety in adults with bronchiectasis

Niksarlıoğlu

Özkan

Günlüoğlu

et al. 2016

NDT

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“…In a recent systematic review of QOL questionnaires in patients with bronchiectasis, there was strong correlation with subjective symptoms but a weak correlation with objective assessments such as FEV 1 , radiological scoring, and exercise capacity (9). The SGRQ has also been used to assess QOL in children with bronchiectasis as young as 8 years old (12). …”

Section: Tools Used To Assess Qolmentioning

confidence: 99%

“…Patients reported worse physical QOL ( z = −2.40, p = 0.018) compared to controls, while parents reported worse QOL in physical ( z = −3.00, p = 0.003), psychosocial ( z = −3.46, p = 0.001), and total areas ( z = −3.47, p = 0.001). They also found that number of exacerbations ( r = −0.23, p < 0.05), hospitalizations ( r = −0.49, p < 0.001), FEV 1 /FVC% predicted ( r = 0.26, p < 0.05), severity of dyspnea ( r = 0.42, p < 0.001), and wheezing ( r = −0.45, p < 0.001) were significant factors associated with QOL (12). …”

Section: Burden Of Disease In Childrenmentioning

confidence: 99%

Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis

Nathan

Bruyne

et al. 2017

Front. Pediatr.

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Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-powered, randomized controlled trials to guide clinicians how to manage NCFB effectively. Quality-of-life (QOL) measures in NCFB are an important aspect of clinical care that has not been studied well. Commonly used disease-specific questionnaires in children with NCFB are the St George’s Respiratory Questionnaire, Short Form-36, the Leicester Cough Questionnaire, and the Parent Cough-Specific Quality of Life questionnaire (PC-QOL). Of these, only the PC-QOL can be used in young children, as it is a parent-proxy questionnaire. We reviewed pediatric studies looking at QOL in children with NCFB and cystic fibrosis. All types of airway clearance techniques appear to be safe and have no significant benefit over each other. Number of exacerbations and hospitalizations correlated with QOL scores, while symptom subscales correlated with lung function, worse QOL, frequent antibiotic requirements, and duration of regular follow-up in only one study. There was a correlation between QOL and age of diagnosis in children with primary ciliary dyskinesia. Other studies have shown no relationship between QOL scores and etiology of NCFB as well as CT changes. As for treatments, oral azithromycin and yoga have demonstrated some improvement in QOL scores. In conclusion, more studies are required to accurately determine important factors contributing to QOL.

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“…However, an England and Wales study reported 12 deaths in the 0 to 14 years age group between 2001 and 2007, 43 and 6 (7%) of 91 children 11.7, SD 2.6 years), depression and trait anxiety scores were not elevated in those with bronchiectasis, but the child-rated physical health QoL scores were significantly lower in those with bronchiectasis compared to controls. 50 The determinants of QoL were related to age, forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC) % predicted, and dyspnea severity. 50 The differences between the Australian 49 and Turkish 48,50 studies likely relate to the different QoL scales used and severity of disease.…”

Section: Epidemiology Prevalence and Burden Of Disease Prevalence Amentioning

confidence: 99%

“…50 The determinants of QoL were related to age, forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC) % predicted, and dyspnea severity. 50 The differences between the Australian 49 and Turkish 48,50 studies likely relate to the different QoL scales used and severity of disease. It is likely that QoL scores correlate to disease severity only in more severe disease, similar to the relationship between spirometry and radiological extent of bronchiectasis; spirometry is often normal in mild or localized disease, 52 and significant correlations between spirometry indices and radiology scores are seen only in more severe disease.…”

Section: Epidemiology Prevalence and Burden Of Disease Prevalence Amentioning

confidence: 99%