The relationship between puberty and social emotion processing

Goddings, AL; Burnett, Stephanie; Klapwijk, Eduard T.; Bird, Geoffrey; Viner, Russell; Blakemore, Sarah‐Jayne

doi:10.1136/archdischild-2012-301885.151

Cited by 9 publications

(12 citation statements)

References 59 publications

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“…For example, white matter integrity as measured with callosal thickness is greater in more sexually mature children [Chavarria, S anchez, Chou, Thompson, Luders, 2014]. Functional activation studies provide evidence for dissociable effects of pubertal hormones and age on the adolescent brain [Galv an, Van Leijenhorst, McGlennen, 2012;Goddings, Burnett Heyes, Bird, Viner, Blakemore, 2012]. Pubertal stage has also been shown to affect volume of subcortical limbic structures [Blanton et al, 2012].…”

Section: Implications For Brain Development In Asdmentioning

confidence: 99%

Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation

2015

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Lay Abstract There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with ASD. Here we investigated the development of local connectivity across three age cohorts of individuals with ASD and typically developing (TD) individuals. We find that in typical development, children exhibit high levels of local connectivity across the brain, while adolescents exhibit lower levels of local connectivity, similar to adult levels. On the other hand, children with ASD exhibit marginally lower local connectivity than TD children, and adolescents and adults with ASD exhibit levels of local connectivity comparable to that observed in neurotypical individuals. During all developmental stages -- childhood, adolescence, and adulthood -- individuals with ASD exhibited lower local connectivity in brain regions involved in sensory processing and higher local connectivity in brain regions involved in complex information processing. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. Thus we demonstrate that local connectivity is disrupted in autism across development, with the most pronounced differences occurring in childhood. Scientific Abstract There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel’s timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age-matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in ch...

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Section: Implications For Brain Development In Asdmentioning

confidence: 99%

Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation

2015

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“…In particular, a few studies addressing the development of emotional face processing suggest an effect of puberty even after accounting for age (Forbes, Phillips et al 2011, Moore, Pfeifer et al 2012, especially expressed as a reduction in amygdala response to emotion as puberty progresses during mid-adolescence (review in Pfeifer 2018). This effect is very small however, and not observed for all markers of puberty (Goddings, Burnett Heyes et al 2012). Also, it is not observed in many behavioural studies of basic emotion recognition (Vetter, Leipold et al 2013, Motta-Mena andScherf 2017).…”

Section: Emotion Modulation Of the Body-selective Areasmentioning

confidence: 75%

Emotion Modulation of the Body-Selective Areas in the Developing Brain

Ross

Gelder

Crabbe

et al. 2019

Preprint

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Emotions are strongly conveyed by the human body and the ability to recognize emotions from body posture or movement is still developing through childhood and adolescence. To date, there are very few studies exploring how these behavioural observations are paralleled by functional brain development. Furthermore, there are currently no studies exploring the development of emotion modulation in these areas. In the current study, we used functional magnetic resonance imaging (fMRI) to compare the brain activity of 25 children (age 6-11), 18 adolescents (age 12-17) and 26 adults while they passively viewed short videos of angry, happy or neutral body movements. We observed that when viewing bodies generally, adults showed higher activity than children bilaterally in the body-selective areas; namely the extra-striate body area (EBA), fusiform body area (FBA), posterior superior temporal sulcus (pSTS) and amygdala (AMY). Adults also showed higher activity than adolescents, but only in right hemisphere body-selective areas. Crucially, however, we found that there were no age differences in the emotion modulation of activity in these areas. These results indicate, for the first time, that despite activity selective to body perception increasing across childhood and adolescence, emotion modulation of these areas in adult-like from 7 years of age.

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“…We examined functional brain connectivity while viewing facial expressions during magnetic resonance imaging (MRI). Recent evidence indicates that brain development may be more closely tied to pubertal status than age (Blakemore et al, 2010), especially within restricted, developmentally sensitive age ranges (Goddings, Heyes, Bird, Viner, & Blakemore, 2012). Also, given that age represents a different stage in maturation for males and females (Schuiling & Likis, 2016), pubertal status -as opposed to age -served as our proxy for maturity.…”

Section: Introductionmentioning

confidence: 99%

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

Petro

Tottenham²,

Neta

2019

Preprint

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Negativity bias is a core feature of depression that is associated with dysfunctional frontoamygdalar connectivity; this pathway is associated with emotion regulation and sensitive to neurobiological change during puberty. We used a valence bias task (ratings of emotional ambiguity) as a potential early indicator of depression risk and differences in frontoamygdalar connectivity. Previous work using this task demonstrated that children normatively have a negative bias that attenuates with maturation. Here, we test the hypothesis that persistence of this negativity bias as manturation ensues may reveal differences in emotion regulation development, and may be associated with increased risk for depression. Within a restricted age range (6-13 years), we tested the moderating role of puberty on relationships between valence bias, depressive symptoms, and frontoamygdalar connectivity. A negative bias was associated with increased depressive symptoms for those at more advanced pubertal stages (within this sample) and less regulatory frontoamygdalar connectivity, whereas a more positive bias was associated with more regulatory connectivity patterns. These data suggest that with maturation, individual differences in positivity biases and associated emotion regulation circuitry confer a differential risk for depression. Longitudinal work is necessary to determine the directionality of these effects and explore the influence of early life events.

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The relationship between puberty and social emotion processing

Cited by 9 publications

References 59 publications

Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation

Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation

Emotion Modulation of the Body-Selective Areas in the Developing Brain

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

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