The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients

The Influence of Glycated Hemoglobin on the Cross Susceptibility Between Type 1 Diabetes Mellitus and Periodontal Disease

“…Serum levels of AGE in patients with T2DM have also been shown to be related to the extent of periodontitis 45 . The presence of AGE in the gingival tissues of individuals with T2DM and periodontitis has also been demonstrated to correlate with levels of nuclear factor‐κB (NF‐κB) activation, 8 , 46 , 47 thus indicating an ongoing inflammatory response.…”

N‐Phenacylthiazolium Bromide Inhibits the Advanced Glycation End Product (AGE)–AGE Receptor Axis to Modulate Experimental Periodontitis in Rats

“…Advanced glycation end products (AGEs), which are commonly formed by the non‐enzymatic glycation of proteins or lipids under extensive degradation or metabolic dysfunctions, 1,2 may interfere with matrix–cell interactions by altering cross‐linking of the extracellular matrix, 3 induce the production of proinflammatory cytokines, activate the AGE receptor (RAGE), and propagate inflammation 1,4 . RAGE expression was also noted in the inflamed gingival tissue of physiologically healthy individuals 5 .…”

Aminoguanidine Inhibits the AGE–RAGE Axis to Modulate the Induction of Periodontitis but Has Limited Effects on the Progression and Recovery of Experimental Periodontitis: A Preliminary Study

“…Advanced glycation end products (AGE), byproducts commonly seen in extensive diabetes or degradation conditions, are the irreversible adducts from the non‐enzymatic glycosylation of proteins or lipids 1,2 . AGE interfere with matrix–cell interactions by altering the cross‐linking of the extracellular matrix, 3 inducing the production of superoxide radicals to activate proinflammatory cytokines and inducible nitric oxide synthase (iNOS), and activating the cellular receptor for AGE (RAGE) to propagate inflammatory signaling 1,4 .…”