The relationship between recurrent aphthous stomatitis, and periodontal disease and Helicobacter Pylori infection

Gülseren, Duygu; Karaduman, Ayşen; Kutsal, Dilek Aslan; Nohutçu, Rahime M.

doi:10.1007/s00784-015-1704-0

Cited by 22 publications

(13 citation statements)

References 32 publications

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Section: Head and Neck Diseasesmentioning

confidence: 99%

“…The role of H. pylori infection in periodontal diseases is well recognized; however, its possible role in the pathogenesis of recurrent aphthous stomatitis (RAS) is still being debated. Gülseren et al, in a cross-sectional study, investigated the role of H. pylori infection in RAS, reporting a statistically significant association (P=.002) 33. Conversely,Gomes et al reviewed 15 experimental studies performed in this fieldand the results demonstrated that RAS ulcers were not associated with the presence of this bacterium in the oral cavity and that there was no evidence that H. pylori infection drived RAS development.…”

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confidence: 99%

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Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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Section: Head and Neck Diseasesmentioning

confidence: 99%

mentioning

confidence: 99%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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“…Nevertheless, the role of dental plaque as an extragastric reservoir in H. pylori transmission is controversial [ 18 – 20 ]. Also, the oral H. pylori infection has been related to oral cavity problems, like gingivitis, periodontitis [ 21 , 22 ], and recurrent aphthous stomatitis (RAS) [ 23 ]. Nisha et al showed a highly significant association was found between periodontal disease and colonization of H. pylori in dental plaque [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence ofHelicobacter pylori vacAGenotypes andcagAGene in Dental Plaque of Asymptomatic Mexican Children

Mendoza-Cantú

Urrutia-Baca

Urbina-Ríos

et al. 2017

BioMed Research International

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The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated the prevalence of H. pylori and the presence of vacA/cagA genotypes in the oral cavity of Mexican children without dyspeptic symptoms. The gingival status was measured, and dental plaque samples (n = 100) were taken. 38% of children were positive for H. pylori 16S rRNA gene by qPCR. A significant association between H. pylori oral infection and gingival status was observed (P < 0.001). In 34.6% (9/26) of mild gingivitis cases, s1m2 genotype was found, while s1m1 was typed in 50% (3/6) of moderate gingivitis. The cagA prevalence among H. pylori-positive children was 80.8% (21/26), 83.3% (5/6), and 16.7% (1/6) of cases of mild gingivitis, moderate gingivitis, and nongingivitis, respectively (P < 0.001). The s1m1/cagA+ combinational genotype was the most detected in children with gingivitis. Our results suggest that the prevalence of H. pylori and detection of vacA/cagA genotypes-associated gastrointestinal disease in the oral cavity could be related to the progression of gingivitis in asymptomatic children.

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“…Većina novijih studija potvrđuje takve rezultate, odnosno kod vrlo malog postotka (4 -10 %) ispitanika dokazana je infekcija s H. pylori [52][53][54] . No, objavljene su i studije u kojima je kod pacijenata s RAS-om dokazan H. pylori u leziji polimeraza lančanom reakcijom (PCR) 55,56 ili su imali ureaza pozitivan test 57 . Li i sur.…”

Section: Bakterije I Rasunclassified

Reccurent aphthous stomatitis

et al. 2018

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Sažetak. Recidivirajući aftozni stomatitis (RAS) najčešća je upalno-ulcerozna bolest oralne sluznice karakterizirana pojavom bolnih, ovalnih ili okruglih ulceracija s uzdignutim eritematoznim haloom i žućkasto-sivkastom pseudomembranom u središtu. Klinički RAS očituje se u tri oblika: minorni, majorni i herpetiformni RAS. Javlja se u 20 % opće populacije, češće u žena, osoba izloženih stresu te višeg socioekonomskog statusa. Lezije se mogu pojaviti u svakoj životnoj dobi, no najčešće se javljaju u drugom desetljeću života. Usprkos visokoj prevalenciji etiopatogeneza RAS-a još uvijek nije razjašnjena. Ovaj pregledni rad donosi najnovije spoznaje o etiologiji, patogenezi, dijagnostici i liječenju RAS-a.Ključne riječi: aftozni stomatitis; dijagnoza; etiologija; liječenje Abstract. Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative disease of the oral mucosa characterised by painfull, round, or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow-grayish pseudomembrane in the centre. Three clinical subtypes of RAS have been established: minor, major and herpetiform RAS. RAS affects approximately 20% of the population, predominantly affects women, individuals under stress and ones of higher socioeconomic status. The lesions can occur at any age, but they mostly occur in the second life decade. Despite its high prevalence, the etiopathogenesis of RAS still remains unclear. This review article presents the recent knowledge about the etiology, pathogenesis, diagnosis, and treatment of RAS.

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The relationship between recurrent aphthous stomatitis, and periodontal disease and Helicobacter Pylori infection

Abstract: The present study indicates that H. pylori plays a role in the development of RAS, but periodontal diseases have no effect on it. Eradicating H. pylori might be useful to prevent RAS.

Cited by 22 publications

References 32 publications

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastric diseases

Prevalence ofHelicobacter pylori vacAGenotypes andcagAGene in Dental Plaque of Asymptomatic Mexican Children

Reccurent aphthous stomatitis

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