The Relationship between Renal Injury and Change in Vitamin D Metabolism in Aged Rats with Insulin Resistance or Type 2 Diabetes Mellitus

Cq, Huang; Ma, GZ; Tao, Tao; Xl, Ma; Feng, Jianxun; Qx, Liu

doi:10.1177/147323000803600211

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…The findings of this study corroborated with previous studies that have shown an upregulation in renal 1-alpha hydroxylase expression in diabetic patients ( 42 , 45 ). However, the findings of this study contrasted other studies that have shown decreased renal-1 alpha hydroxylase expression in the diabetic state ( 43 , 44 ). The upregulation in renal-1 alpha hydroxylase in the DIPD group may suggest that there is an increased demand to synthesis calcitriol in the pre-diabetic state.…”

Section: Discussioncontrasting

confidence: 99%

“…Disturbances in kidney function and vitamin D metabolism can lead to excessive urinary calcium excretion and hyperparathyroidism ( 26 ). Studies have shown that a loss of kidney function in T2DM leads to a decline in circulating plasma calcitriol concentrations ( 43 , 44 ). Renal injury and the accumulation of metabolites in the diabetic kidney contribute to 1-alpha hydroxylase inhibition and lower circulating calcitriol levels ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that a loss of kidney function in T2DM leads to a decline in circulating plasma calcitriol concentrations ( 43 , 44 ). Renal injury and the accumulation of metabolites in the diabetic kidney contribute to 1-alpha hydroxylase inhibition and lower circulating calcitriol levels ( 43 ). In this study, the DIPD group had significantly increased renal-1 alpha hydroxylase expression by comparison to the NPD group.…”

Section: Discussionmentioning

confidence: 99%

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Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers

2022

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Derangements to the functioning of calcium-regulating organs have been associated with type 2 diabetes mellitus (T2DM), a condition preceded by pre-diabetes. Type 2 diabetes has shown to promote renal calcium wastage, intestinal calcium malabsorption and increased bone resorption. However, the changes to the functioning of calcium-regulating organs in pre-diabetes are not known. Subsequently, the effects of diet-induced pre-diabetes on the functioning of calcium-regulating organs in a rat model for pre-diabetes was investigated in this study. Male Sprague Dawley rats were separated into two groups (n=6, each group): non-pre-diabetic (NPD) group and a diet-induced pre-diabetic (DIPD) group for 20 weeks. After the experimental period, postprandial glucose and HOMA-IR were analysed in addition to plasma and urinary calcium concentrations. Gene expressions of intestinal vitamin D (VDR), intestinal calbindin-D9k, renal 1-alpha hydroxylase and renal transient receptor potential vanilloid 5 (TRPV5) expressions in addition to plasma osteocalcin and urinary deoxypyridinoline concentrations were analysed at week 20. The results demonstrated significantly increased concentrations of postprandial glucose, HOMA-IR and urinary calcium in addition to unchanged plasma calcium levels in the DIPD group by comparison to NPD. Renal TRPV5, renal 1-alpha hydroxylase, intestinal VDR and intestinal calbindin-D9k expressions were increased in the DIPD group by comparison to NPD. Furthermore, plasma osteocalcin levels were increased and urine deoxypyridinoline levels were decreased in the DIPD group by comparison to NPD. These observations may suggest that calcium-regulating organs compensate for the changes to calcium homeostasis by inducing increased renal calcium reabsorption, increased intestinal calcium absorption and decreased bone resorption followed by increased bone formation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers

2022

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“…The number of obese individuals, particularly those suffering from abdominal obesity, has increased due to the change of living standards, resulting from the increased levels of sugar in their diet, smoking and alcohol consumption. Therefore, the higher prevalence rate of DM observed may be due to abdominal obesity, as it had been reported to be the basis of IR (6).…”

Section: Introductionmentioning

confidence: 90%

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Liu

2016

Molecular Medicine Reports

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Thymoquinone is the main active monomer extracted from black cumin and has anti‑inflammatory, antioxidant and anti‑apoptotic functions. However, the protective effects of thymoquinone on cardiovascular function in diabetes remain to be fully elucidated. The present study aimed to investigate the molecular mechanisms underling the beneficial effects of thymoquinone on the cardiovascular function in streptozotocin‑induced diabetes mellitus (DM) rats. Supplement thymoquinone may recover the insulin levels and body weight, inhibit blood glucose levels and reduce the heart rate in DM‑induced rats. The results indicated that the heart, liver and lung to body weight ratios, in addition to the blood pressure levels, were similar for each experimental group. Treatment with thymoquinone significantly reduced oxidative stress damage, inhibited the increased endothelial nitric oxide synthase protein expression and suppressed the elevation of cyclooxygenase‑2 levels in DM‑induced rats. In addition, thymoquinone significantly suppressed the promotion of tumor necrosis factor‑α and interleukin‑6 levels in the DM‑induced rats. Furthermore, administration of thymoquinone significantly reduced caspase‑3 activity and the promotion of phosphorylated‑protein kinase B (Akt) protein expression levels in DM‑induced rats. These results suggest that the protective effect of thymoquinone improves cardiovascular function and attenuates oxidative stress, inflammation and apoptosis by mediating the phosphatidylinositol 3‑kinase/Akt pathway in DM‑induced rats.

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Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition

Chanet

Salles

Guillet

et al. 2017

The Journal of Nutritional Biochemistry

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The Relationship between Renal Injury and Change in Vitamin D Metabolism in Aged Rats with Insulin Resistance or Type 2 Diabetes Mellitus

Abstract: Insulin resistance (IR),

Cited by 4 publications

References 34 publications

Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers

Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition

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