The relationship between restless legs syndrome and bronchial asthma

Güngen, Adil Can; Güngen, Belma Doğan; Aydemir, Yusuf; Aras, Yeşim Güzey; Çoban, Hikmet; Düzenli, Hasan

doi:10.1111/crj.12684

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…Concurring with previous evidence from clinic populations that implemented objective measures of parasomnia, the current study verifies the positive relationship between parasomnia symptoms (enuresis, sleep restlessness, sleep terror, and bruxism) and wheeze/asthma. [13][14][15][16][17][18][19][20][21][22][23][24][25] Moreover, our finding extends preliminary work with novel evidence for the relationship of the other parasomnia symptoms (sleep talking, sleepwalking, and nightmares) with childhood wheeze/ asthma. Two other studies of enuresis in the early 1970s yielded inconsistent results.…”

Section: Discussionsupporting

confidence: 73%

“…To our knowledge, 15 studies have looked at a certain kind of parasomnia symptom with conflicting results. Restless leg syndrome, 13,14 bruxism, [15][16][17][18] and sleep terror 19,20 were found to have supportive correlations, whereas enuresis had inconsistent results, with 5 positive relationships [21][22][23][24][25] and 2 non-significant associations. 26,27 Others, like sleep talking, sleepwalking, sleep terror, and nightmares, have rarely been touched by previous studies.…”

Section: Introductionmentioning

confidence: 99%

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Association of Parasomnia Symptoms with Risk of Childhood Asthma and the Role of Preterm Birth

Chen¹,

Zhao²,

Lyu³

et al. 2022

NSS

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Purpose To examine whether parasomnia symptoms are associated with increased odds of childhood asthma and wheeze, and the role of preterm birth. Patients and Methods The Shanghai Children’s Allergy Study was cross-sectionally conducted in 31 kindergartens and 17 primary schools in Shanghai, China. After excluding the missing data of gestational week and child’s age, this study included a total of 16,487 individuals with a mean age of 7.74 years and 52.4% of males. The association between parasomnia symptoms and wheeze/asthma was assessed by univariate and multivariate analyses. The interaction effects of parasomnias and preterm birth were primarily evaluated by P for multiplicative interaction, and the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI) were also measured. Results Parasomnias, especially rapid eye movement (REM) parasomnia symptoms, were associated with an increased risk of childhood wheeze/asthma, and the interaction between parasomnia and preterm birth exhibited an excess risk of current wheeze (RERI, 1.43; 95% CI, 0.41–2.45) and ever asthma (RERI, 0.75; 95% CI, 0.01–1.50). In the stratification analyses, the combination of parasomnia symptoms and preterm birth had higher odds of wheeze/asthma. And the odds of current wheeze (OR, 4.55; 95% CI, 1.69–12.25; p =0.003) and ever asthma (OR, 6.17; 95% CI, 2.36–16.11; p <0.001) were much higher in cumulative parasomnia symptoms plus very preterm birth. And sensitive analyses were further conducted in populations without sleep disordered breathing (SDB), and an allergen test subgroup, yielding similar results. Conclusion Parasomnia symptoms are associated with increased odds of childhood wheeze/asthma, and the odds were even higher in premature population. The findings suggest that parasomnia symptoms, as a developmental sleep disorder, are supposed to be closely watched among children who have asthma or are at risk for asthma, and that preterm children deserve more attention.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Association of Parasomnia Symptoms with Risk of Childhood Asthma and the Role of Preterm Birth

Chen¹,

Zhao²,

Lyu³

et al. 2022

NSS

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“…[32] According to the results of a different study in our country, the diagnosis of RLS is more common in people with asthma than in healthy individuals, and the frequency of RLS increases as asthma control decreases. [33] In the literature, there is also a study showing that the frequency of RLS is higher in urticaria patients than in the control group. [34] Since studies evaluating the relationship between allergic diseases and RLS are mostly conducted in adult patients, further studies are needed to evaluate the relationship between different allergic diseases and RLS, especially in the pediatric patient group.…”

Section: Discussionmentioning

confidence: 99%

Alerjik rinit tanılı çocuklarda huzursuz bacak sendromunun değerlendirilmesi

ALTAS,

BİBİNOĞLU AMİROV,

ALTAŞ

et al. 2023

Journal of Contemporary Medicine

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Aim: It was aimed to evaluate the frequency of restless legs syndrome (RLS) in children with a diagnosis of allergic rhinitis (AR). Material and Method: The study is case-control type. Age, gender, height, weight, Body Mass Index (BMI), allergic rhinitis symptom score, allergic rhinitis severity, allergy tests, total IgE, eosinophil values of the case group were examined. Gender, age, height, weight and BMI were also calculated in the control group. Patients in both groups were questioned using the International Restless Legs Syndrome Study Group's (IRLSSG) questionnaire containing the latest diagnostic criteria and severity scoring revised for the pediatric age group. Neurological examination, questionnaire and RLS severity scoring results of the patients were performed by a pediatric neurologist. Results: In the study, the data of a total of 230 children, 115 AR cases and 115 control groups, were evaluated. The frequency of restless legs syndrome in children with allergic rhinitis was significantly higher than in the control group (15.7% and 5.2%, respectively; p=0.010). The clinical severity of RLS patients was mostly moderate in both the case and control groups [44.4% (n=8) and 50% (n=3), respectively]. Conclusion: According to the results of our study; restless legs syndrome was observed more frequently in patients with allergic rhinitis compared to the control group.

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Section: Movement Disordersmentioning

confidence: 99%

“…In adults with asthma there is an increased rate of RLS compared with healthy individuals 39 . This is inversely associated with asthma control, as well as with depression and anxiety, but not associated with asthma medications use 39 . We are unaware of any studies on RLS in children, although one abstract presented at the 2017 American Thoracic Society Conference reported increased periodic limb movements, which may support a diagnosis of RLS, in children with uncontrolled asthma compared with those with well controlled asthma 40 .…”

Section: Movement Disordersmentioning

confidence: 99%

Sleep disorders in children with asthma

Reiter

Ramagopal

Gileles‐Hillel

et al. 2021

Pediatric Pulmonology

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Asthma and sleep disorders are both common in childhood, and often co‐exist in the same child. Moreover, studies have shown that in many children the rate of one is influenced by the other. Sleep disorders can be classified into six different groups—insomnia, hypersomnia, parasomnia, movement disorders, circadian disorders, and sleep‐related breathing disorders. Children with asthma often present with complaints of insomnia with poor sleep quality, difficulty falling asleep and sleep disruptions. These complains are often associated with asthma control. They may also complain of daytime sleepiness and have higher rates of parasomnias, such as night terrors and nocturnal enuresis when compared with their healthy peers. Whether movement and circadian disorders are also more prevalent in children with asthma is less clear. Finally, there is a complex bidirectional interaction between sleep‐related breathing disorders and asthma: poor sleep and sleep disorders may worsen asthma, and asthma, particularly when it is poorly controlled, may impair sleep. In the current review we examine the association of each of the sleep disorders with asthma and review the common pathophysiological pathways. We hope to convince the reader that appropriate management of asthma must include inquiries into the patient's sleep, and vice versa.

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The relationship between restless legs syndrome and bronchial asthma

Cited by 8 publications

References 20 publications

Association of Parasomnia Symptoms with Risk of Childhood Asthma and the Role of Preterm Birth

Association of Parasomnia Symptoms with Risk of Childhood Asthma and the Role of Preterm Birth

Alerjik rinit tanılı çocuklarda huzursuz bacak sendromunun değerlendirilmesi

Sleep disorders in children with asthma

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