The Relationship Between Schizophrenia and Frontotemporal Dementia

Cooper, Joseph J.; Ovsiew, Fred

doi:10.1177/0891988713490992

Cited by 37 publications

(25 citation statements)

References 35 publications

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“…The hyperorality observed in FTD, particularly for sweets, is also noted to be uncommon in schizophrenia [26,37]. Neuroimaging features may also aid in the diagnosis, as the frontotemporal atrophy and hypoperfusion/hypometabolism of bvFTD are typically more extreme that that observed in schizophrenia (Fig.…”

Section: Psychosis In Schizophrenia Vs Ftdmentioning

confidence: 90%

“…The course of symptoms can be instructive, as the course of disease tends to stabilize in schizophrenia but in FTD a continual decline occurs [37]. The hyperorality observed in FTD, particularly for sweets, is also noted to be uncommon in schizophrenia [26,37].…”

Section: Psychosis In Schizophrenia Vs Ftdmentioning

confidence: 98%

“…While the onset of schizophrenia tends to occur at an earlier age than FTD, in the second to third decade of life compared to the fifth or sixth decade of life for FTD [37], an estimated ∼25 % of schizophrenia presents after 40 years of age [31,38].…”

Section: Psychosis In Schizophrenia Vs Ftdmentioning

confidence: 99%

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Psychotic Symptoms in Frontotemporal Dementia

Hall

Finger

2015

Curr Neurol Neurosci Rep

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Although psychotic features have long been recognized in association with frontotemporal dementia (FTD), recent genetic discoveries enabling further subtyping of FTD have revealed that psychotic symptoms are frequent in some forms of FTD. Hallucinations and delusions can even precede onset of other cognitive or behavioural symptoms in patients with FTD. In this review, we explore the frequency and types of psychotic symptoms reported in patients with FTD, as well as in other neuropsychiatric disorders, to aid practitioners' consideration of these features in the diagnosis of FTD and related disorders.

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Section: Psychosis In Schizophrenia Vs Ftdmentioning

confidence: 90%

Section: Psychosis In Schizophrenia Vs Ftdmentioning

confidence: 98%

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Psychotic Symptoms in Frontotemporal Dementia

Hall

Finger

2015

Curr Neurol Neurosci Rep

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“…Recently, it has been acknowledged that there is an overrepresentation of other psychiatric disorders, such as schizophrenia and bipolar disorder, in close relatives of FTD patients. A possible association between FTD and schizophrenia has also been discussed (Cooper and Ovsiew, 2013 ; Harciarek et al , 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Psychotic symptoms in frontotemporal dementia: a diagnostic dilemma?

Waldö

Gustafson

Passant

et al. 2015

International Psychogeriatrics

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Background:Frontotemporal dementia (FTD) constitutes a spectrum of neurodegenerative disorders associated with degeneration of, predominantly, the frontal and temporal lobes. The clinical heterogeneity is evident, and early diagnosis is a challenge. The primary objectives were to characterize psychotic symptoms, initial clinical diagnoses and family history in neuropathologically verified FTD-patients and to analyze possible correlations with different neuropathological findings.Methods:The medical records of 97 consecutive patients with a neuropathological diagnosis of frontotemporal lobar degeneration (FTLD) were reevaluated. Psychotic symptoms (hallucinations, delusions, paranoid ideas), initial diagnosis and family history for psychiatric disorders were analyzed.Results:Psychotic symptoms were present in 31 patients (32%). There were no significant differences in age at onset, disease duration or gender between patients with and without psychotic symptoms. Paranoid ideas were seen in 20.6%, and hallucinations and delusions in 17.5% in equal measure. Apart from a strong correlation between psychotic symptoms and predominantly right-sided brain degeneration, the majority of patients (77.4%) were tau-negative. Only 14.4% of the patients were initially diagnosed as FTD, while other types of dementia were seen in 34%, other psychiatric disorders in 42%, and 9.2% with other cognitive/neurological disorders. The patients who were initially diagnosed with a psychiatric disorder were significantly younger than the patients with other initial clinical diagnoses. A positive heredity for dementia or other psychiatric disorder was seen in 42% and 26% of the patients respectively.Conclusions:Psychotic symptoms, not covered by current diagnostic criteria, are common and may lead to clinical misdiagnosis in FTD.

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“…a common genetic or neurobiological liability or mutual risk factors, with certain severe mental disorders such as schizophrenia. This shared etiology has been motivated by evidence of a number of genetic mutations [ 11 , 12 , 13 ] and similar disease processes [ 14 , 15 , 16 ], such as hyperphosphorylation of a microtubule-associated protein in the brain, mediating both schizophrenia and dementia. Others advocate that a possible association between schizophrenia and dementia would not be ascribed to common etiology, but rather to a by-product of the higher rates of chronic medical conditions, substance abuse, and unhealthy lifestyle among individuals with schizophrenia compared to the general population.…”

Section: Introductionmentioning

confidence: 99%

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

Rohde

Agerbo

Nielsen

2016

Dement Geriatr Cogn Disord Extra

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Background/Aims: Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia. Methods: All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study. Regressions were performed to evaluate the association between offspring with schizophrenia and Alzheimer's dementia. Results: Individuals with offspring with schizophrenia did not have an increased risk of Alzheimer's dementia [incidence rate ratio (IRR), 0.97; 95% CI, 0.88-1.07] compared to individuals with offspring without psychiatric contact. This finding remained stable when evaluating early-onset (IRR, 1.10; 95% CI, 0.91-1.31) and late-onset Alzheimer's dementia (IRR, 0.92; 95% CI, 0.88-1.07). Similar findings were made for vascular and unspecified dementia. Conclusion: The finding of no familial coaggregation between schizophrenia and Alzheimer's dementia may suggest that no common etiology between the disorders exists. This may indicate that the excess risk of dementia in individuals with schizophrenia is a by-product of the higher rates of somatic comorbidity and adverse health risk factors among these individuals.

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The Relationship Between Schizophrenia and Frontotemporal Dementia

Cited by 37 publications

References 35 publications

Psychotic Symptoms in Frontotemporal Dementia

Psychotic Symptoms in Frontotemporal Dementia

Psychotic symptoms in frontotemporal dementia: a diagnostic dilemma?

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

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