The Relationship Between Scoring Systems and Cytokine Levels in Neonatal Sepsis

Çaksen, H; Kurtoglu, S; Hallaç, I K; Üstünbas, H B; Üzüm, K; Kiliç, H

doi:10.47102/annals-acadmedsg.v32n3p418

Ann Acad Med Singap

2003

DOI: 10.47102/annals-acadmedsg.v32n3p418

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The Relationship Between Scoring Systems and Cytokine Levels in Neonatal Sepsis

H Çaksen,

S Kurtoglu,

I K Hallaç

et al.

Abstract: In this study, 20 newborn infants with sepsis were evaluated and scored according to the criteria of Töllner and Rodwell and associates. Leukocyte count, serum C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were also studied in all infants. The aim of this study was to determine if a relationship exists between the scoring systems and the cytokine levels in neonatal sepsis. The infants were divided into two groups as blood culture positive and negative. Blood culture… Show more

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Cited by 2 publications

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Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Uçar

Yıldız

AKŞİT

et al. 2008

Mediators of Inflammation

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Background. Sepsis is an important cause of mortality in newborns. However, a single reliable marker is not available for the diagnosis of neonatal late-onset sepsis (NLS). The aim of this study is to evaluate the value of serum amyloid A (SAA) and procalcitonin (PCT) in the diagnosis and follow-up of NLS. Methods. 36 septic and healthy newborns were included in the study. However, SAA, PCT, TNF-α, IL-1β, and CRP were serially measured on days 0, 4, and 8 in the patients and once in the controls. Töllner's sepsis score (TSS) was calculated for each patient. Results. CRP, PCT, and TNF-α levels in septic neonates at each study day were significantly higher than in the controls (P = .001). SAA and IL-1β levels did not differ from healthy neonates. The sensitivity and specificity were 86.8% and 97.2% for PCT, 83.3% and 80.6% for TNF-α, 75% and 44.4% for SAA on day 0. Conclusion. Present study suggests that CRP seems to be the most helpful indicator and PCT and TNF-α may be useful markers for the early diagnosis of NLS. However, SAA, IL-1β, and TSS are not reliable markers for the diagnosis and follow-up of NLS.

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Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Uçar

Yıldız

AKŞİT

et al. 2008

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: A meta-analysis

Liu²,

Sun

et al. 2010

Scandinavian Journal of Infectious Diseases

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A meta-analysis was performed to assess the accuracy of the procalcitonin (PCT) test for diagnosing neonatal sepsis. The major databases, MEDLINE, EMBASE and the Cochrane Library were searched for studies published between January 1996 and May 2009 that evaluated PCT as a diagnostic marker for neonatal sepsis and provided sufficient data to calculate sensitivity and specificity. Twenty-two studies were included in the analysis. Trials that evaluated the PCT test for the diagnosis of early-onset neonatal sepsis at different time points (birth, 0-12 h, 12-24 h, and 24-48 h) and late-onset neonatal sepsis (LONS) all showed moderate accuracy (Q* = 0.79, 0.86, 0.81, 0.82, and 0.77, respectively). The PCT test was more accurate than the C-reactive protein (CRP) test for the diagnosis of LONS. A sensitivity analysis found that differences in PCT assay producer, gestational age and severity of sepsis in the study population may partially explain the between-studies heterogeneity. The PCT test showed moderate accuracy in diagnosing neonatal sepsis, regardless of differences in diagnostic criteria and time points for testing. For the diagnosis of LONS, the PCT test showed better accuracy than the CRP test. PCT is a valuable additional tool for the diagnosis of neonatal sepsis.

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The Relationship Between Scoring Systems and Cytokine Levels in Neonatal Sepsis

Cited by 2 publications

References 7 publications

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: A meta-analysis

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