The Relationship between Senile Dementia (Alzheimer Type) and Depression

Kral, V. A.

doi:10.1177/070674378302800414

Cited by 159 publications

(75 citation statements)

References 8 publications

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“…Thus, when rigorous research clinical criteria are employed to obtain a diagnosis of Alzheimer's disease -presumably to make certain the cases were indeed of Alzheimer's disease, a course of action that favours the inclusion of more severe cases -there was no depression in 30 cases of dementia (Knesevich et al 1983). Krai (1983) has considered the significance of depression in Alzheimer's disease. There cannot be any certainty on this point, but it would appear that depression does not carry any prognostic implications and the treatment of the depression by antidepressant drugs with anticholinergic properties does not alter the natural history of Alzheimer's disease.…”

Section: Depression In Dementiamentioning

confidence: 99%

“…There cannot be any certainty on this point, but it would appear that depression does not carry any prognostic implications and the treatment of the depression by antidepressant drugs with anticholinergic properties does not alter the natural history of Alzheimer's disease. Krai (1983) also took the opportunity of studying 22 'pseudodements' on follow-up and found that 20 of them had developed progressive dementia, the clinical appearances being that of Alzheimer's disease, and that 11 of these had died. Histological confirmation was available in three of these patients.…”

Section: Depression In Dementiamentioning

confidence: 99%

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Depression and dementia: the multi-faceted relationship

Mahendra¹

1985

Psychol. Med.

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Section: Depression In Dementiamentioning

confidence: 99%

Section: Depression In Dementiamentioning

confidence: 99%

Depression and dementia: the multi-faceted relationship

Mahendra¹

1985

Psychol. Med.

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“…12,21 Follow-up of "depressive pseudodementia" in clinical and in community settings has shown that subsequent irreversible dementia frequently develops in these subjects. 3,11,34,35 It is, of course, difficult to pinpoint the actual onset of most chronic diseases, including AD and depression. We used all available evidence to estimate the date of onset of cognitive and functional manifestations of dementia.…”

Section: Commentmentioning

confidence: 99%

The Temporal Relationship Between Depressive Symptoms and Dementia

Chen¹,

Ganguli²,

Mulsant³

et al. 1999

Arch Gen Psychiatry

295

205

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“…Aside from the overlap of symptoms in both illnesses (to be discussed further on) is the suggestion based on findings by a number of groups [9][10][11][12][13] that an earlier psychiatric illness, particularly depression, is a risk factor for Alzheimer's disease. This may be especially important if the depressive episode occurs within two years of the diagnosis of dementia, 14 and might then be considered a "prodrome" of dementia.…”

Section: Etiology Of Depressive Syndromes In Dementiamentioning

confidence: 99%

“…A possible factor facilitating the expression of depressive symptoms in early dementia is the retention of insight into cognitive deterioration, 9,24,32 although contradictory evidence in this regard has been published. [33][34][35] Bungener et al 36 found that loss of control was a significant factor for the development of depressive symptoms and it would seem intuitive that remaining awareness of increasing cognitive deficits might interact with gradual loss of autonomy and control to cause demoralization.…”

Section: Depressive Symptomsmentioning

confidence: 99%

Depressive Syndromes in Dementia

Thorpe

Groulx

2001

Can. J. Neurol. Sci.

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. Overall goals and objectives, as well as procedures for consensus development, were based on the Canadian Medical Association guidelines for clinical practice guidelines, 1 a s described in the summary article by Patterson et al. 2 In this paper we present general information about the association between depression and dementia, then summarize various clinical presentations in dementia that have prominent depressive features, review diagnostic difficulties and lastly summarize treatment of depressive disorder in dementia in more detail, culminating in the main consensus conference recommendations.An initial Medline search was performed prior to the ABSTRACT: Background: Depressive syndromes in dementia are common, treatment is challenging and controlled intervention studies are small in number. The goal of this paper is to review known information about the etiology, epidemiology and treatment of these syndromes, as summarized at the recent Canadian Consensus Conference on Dementia. Methods: A number of Medline searches were performed (most recently updated in October 2000) using the subject categories dementia and depression, or apathy or emotional lability and other relevant articles were also reviewed. The background article was edited and amended at the Consensus Conference on Dementia. Final recommendations appearing in the summary article by Patterson et al were accepted by the group consensus process. Clinical discussion and informational updates were added for the current text by the authors. Results: Depressive syndromes, ranging in severity from isolated symptoms to full depressive disorders, increase in dementia. While clear-cut depressive disorder is increased in this population, sub-syndromal disorders are even more common and cause considerable distress. Antidepressant treatment may improve the quality of life in depressed, demented people, although it is less successful than in those without cognitive impairment and carries more risk of iatrogenic effects. Conclusions: Physicians should be alert to the presence of depressive syndromes in dementia. Depressive illness should be treated and, when necessary, referral should be made to an appropriate specialist. Treatment must minimize iatrogenic effects. Although there is some support for treatment of syndromes that do not meet criteria for depressive disorder or dysthymia, the first line of intervention in these situations should involve nonpharmacological approaches.RÉSUMÉ: Syndromes dépressifs dans la démence. Introduction: Les syndromes dépressifs sont fréquents dans la démence, leur traitement est un défi et il existe peu d'études d'intervention contrôlées. Le but de cet article était de revoir les connaissances sur l'étiologie, l'épidémiologie et le traitement de ces syndromes, conformément au résumé fait à la Conférence canadienne de consensus sur la démence. Méthodes: Des recherches dans Medline ont été effectuées (avec mise à jour en octobre 2000) utilisant la démence et la dépression comme catégorie de sujet ou l'apathie ou la labilité ...

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The Relationship between Senile Dementia (Alzheimer Type) and Depression

Abstract: The symptomatology and treatment of the various types of depressions found in Alzheimer patients are briefly described as well as a discussion of some of the interesting theoretical problems that are posed.

Cited by 159 publications

References 8 publications

Depression and dementia: the multi-faceted relationship

Depression and dementia: the multi-faceted relationship

The Temporal Relationship Between Depressive Symptoms and Dementia

Depressive Syndromes in Dementia

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