The relationship between serum 25-hydroxy vitamin D concentration and obesity in type 2 diabetic patients and healthy subjects

Taheri, Ensiyeh; Saedisomeolia, Ahmad; Djalali, Mahmoud; Qorbani, Mostafa; Civi, Manouchehr Madani

doi:10.1186/2251-6581-11-16

Cited by 57 publications

(43 citation statements)

References 39 publications

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“…In a cross sectional Iranian study by Taheri and colleagues [19], the prevalence of vitamin D deficiency was 83.3% in diabetic patients and 75.6% in healthy subjects. Another cross sectional study among rural and urban adult Indians, Harinarayan et al ., [20] also observed 44% and 62% for rural and urban men respectively and 70% and 75% deficiency for rural and urban women respectively.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

et al. 2017

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BackgroundVitamin D plays a major role in physiological processes that modulate mineral metabolism and immune function with probable link to several chronic and infectious conditions. Emerging data suggests a possible influence of vitamin D on glucose homeostasis. This study sought to provide preliminary information on vitamin D status among Ghanaian type 2 diabetics and assessed its association with glucose homeostasis.MethodsIn a case control study, 118 clinically diagnosed Type 2 Diabetes Mellitus (T2DM) patients attending Diabetic Clinic at the Nkawie Government Hospital were enrolled between October and December 2015. Hundred healthy non-diabetics living in Nkawie district were selected as controls. Structured questionnaires were administered to obtain socio-demographic data. Venous blood samples were taken from both cases and controls to estimate their FBG, Lipid profile spectrophotometrically and IPTH, 25OHD by ELISA. Statistical analyses were performed using SPSS v20.0 Statistics.ResultsThe average age of the study participants was 58.81years for cases and 57.79year for controls. There was vitamin D deficiency of 92.4% among T2DM cases and 60.2% among the non diabetic controls. Vitamin D deficiency did not significantly associate with HOMA-β [T2DM: r2 = 0.0209, p = 0.1338 and Control: r2 = 0.0213, p = 0.2703] and HOMA-IR [T2DM: r2 = 0.0233, p = 0.1132 and Control: r2 = 0.0214, p = 0.2690] in both the controls and the cases.ConclusionVitamin D deficiency is prevalent in both T2DM and non-diabetics. There is no association between vitamin D deficiency and insulin resistance or beta cell function in our study population. Vitamin D supplementation among type 2 diabetics is recommended.

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Section: Discussionmentioning

confidence: 99%

Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

et al. 2017

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“…Similar results are reported in previous studies. [232425] Need et al . [26] showed that the patients who had higher levels of Vitamin D concentration had lower FBS in comparison with the other groups.…”

Section: Discussionmentioning

confidence: 99%

Role of Vitamin D on glycemic control and oxidative stress in type 2 diabetes mellitus

2017

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Background:Vitamin D deficiency may play a key role in the development of impaired glucose tolerance, type 2 diabetes mellitus (T2DM), and metabolic syndrome. Several studies have shown that Vitamin D has an antioxidant property. We aimed to investigate 25-hydroxy Vitamin D (25[OH]D) levels in patients with T2DM and in nondiabetic healthy controls and to ascertain the impact of 25(OH)D levels on glycemic control and oxidative stress in T2DM patients.Materials and Methods:Thirty male patients with T2DM and twenty age- and socioeconomic status-matched male healthy controls were included in the study. Fasting and postprandial blood sugar and glycated hemoglobin (HbA1c) were measured. Enzyme activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) was determined by spectrophotometric assay, and serum levels of 25(OH)D were measured using radioimmunoassay.Results:Serum Vitamin D levels were significantly lower in patients with T2DM than healthy controls (P = 0.015). There was a significantly lower GPx activity in patients with T2DM than controls (P = 0.048), but the difference in SOD activity did not reach statistical significance. There was a significant negative correlation between serum Vitamin D levels and HbA1c (P = 0.016), but no statistical correlation was shown between serum Vitamin D levels and GPx and SOD.Conclusion:We conclude that low level of Vitamin D might play a significant role in T2DM pathogenesis. Hence, Vitamin D supplementation may improve glycemic control and oxidative stress in T2DM.

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“…[40] Another study carried in Iran showed that prevalence of vitamin D deficiency was higher T2DM patients than controls (82.1% vs.75.6%) but there was no statistical significant difference between both groups as regards to vitamin D level (p=0.75). [41 Also no statistical significant difference between mean level of vitamin D was observed in retrospective study that evaluated the medical records of patients with T2DM and healthy controls in Turkey, 25(OH) vitamin D mean± SD was (21.1±8.6 vs.21.4±11.8) among diabetes patients and controls respectively (p=0.302). [42] However, several studies have demonstrated statistical significant lower vitamin D level among type2 diabetic patient.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study

Ashiry¹,

Gadallah²,

Mashahit³

et al. 2018

Fayoum University Medical journal

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Diabetes mellitus is one of the most common metabolic diseases in the world that can affect nearly every organ system in the body. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of study; to investigate vitamin D level in type 2 diabetes and controls. A retrospective case control study with 47 newly diagnosed diabetic patients aged (35-70 years) and 54 controls matching age±5years and gender. Measuring HbA1c, FBG, assay serum 25(OH) D level were done for patients and/or controls. Results of current study, showed a more severe vitamin D deficiency in newly diagnosed diabetes than controls (46.8% vs.33.3%) and difference between vitamin D level in newly diagnosed diabetes compare to controls was not statistical significant (p=0.108). Conclusion: no statistical significant difference between newly diagnosed diabetes and controls concerning to vitamin D level.

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The relationship between serum 25-hydroxy vitamin D concentration and obesity in type 2 diabetic patients and healthy subjects

Cited by 57 publications

References 39 publications

Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

Role of Vitamin D on glycemic control and oxidative stress in type 2 diabetes mellitus

Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study

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