The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and  β-Cell Function in Newly Diagnosed Type 2 Diabetes

Gao, Yuan; Wu, Xinchi; Fu, Qi; Li, Yanyun; Yang, Tao; Tang, Wei

doi:10.1155/2015/636891

Cited by 23 publications

(14 citation statements)

References 24 publications

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“…In studies on the association between vitamin D and beta cell function, previous results were not consistent according to ethnicity and country, healthy subjects and subjects with disease. ( 16 – 20 , 30 – 32 ) Kayaniyil and his colleagues ( 16 ) evaluated the association between 25(OH)D and beta cell dysfunction in type 2 diabetes and suggested that the serum 25(OH)D level was positively associated with beta cell function ( p <0.001). On the other hand, some studies reported that the association of serum 25(OH)D level and HOMA- B is not relevant.…”

Section: Discussionmentioning

confidence: 99%

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

Yoon

Jeon²,

Park

et al. 2016

J. Clin. Biochem. Nutr.

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The purpose of this study is to look at these relationships in non-diabetic Korean adults. This study was based on data from the KNHANES V-1, which is representative of the population of Korea. A total of 5,492 participants (≥20 years in age) without type 1 or type 2 diabetes, assessed for serum 25-hydroxyvitamin D [25(OH)D], fasting blood glucose and insulin, as well as anthropometric variables, were included in the analyses. The key study results were as follows: First, vitamin D status [vitamin D deficient, 25(OH)D <25 nM; vitamin D insufficient, 25(OH)D ≥25, <50 nM; vitamin D sufficient, 25(OH)D ≥50 nM] was inversely associated with homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in model 2 (adjusted for age and gender) and 3 (further adjusted for smoking, alcohol drinking, regular exercise, systolic and diastolic blood pressure, waist circumference, and body mass index). Second, in model 4, when further adjusted for total cholesterol, triglycerides, and HDL-C, vitamin D status was inversely associated with HOMA-B. However, association of vitamin D status and HOMA-IR was no longer significant. In conclusion, vitamin D was inversely associated with beta cell function in non-diabetic Korean adults but was not associated with insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

Yoon

Jeon²,

Park

et al. 2016

J. Clin. Biochem. Nutr.

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show abstract

“… Diabetic subject studies for the lower BMI quartile (<30): Forest plot shows the correlation between vitamin D status and BMI [ 54 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. A random effect model was used to calculate the correlations and 95% CI ( I 2 = 54.584%, p = 0.00).…”

Section: Figurementioning

confidence: 99%

“… Authors’ assessment of the risk of bias in the diabetic subject studies: Data shown for each individual study (the plus sign shows a low risk of bias, the minus sign shows a high risk of bias, and the question mark indicates that the risk of bias is unknown) [ 22 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. …”

Section: Figurementioning

confidence: 99%

Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Rafiq

Jeppesen

2018

Nutrients

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The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

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“…Few studies have focused on the sex disparity in the relationship between vitamin D and insulin sensitivity and b-cell dysfunction up to now. Gao et al has reported that the vitamin D level is significantly associated with female b-cell function, whereas in the male population, these associations are null (38). For the Western population, vitamin D deficiency was found to be associated with decreased insulin production in males with T2DM (9).…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Association of Serum 25-Hydroxyvitamin D3 with Insulin Resistance in Chinese Han Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Wang

Qian

et al. 2018

J Nutr Sci Vitaminol

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SummaryThis study aimed to explore the association between serum 25-hydroxyvitamin D (25(OH)D) and insulin resistance as well as b-cell function in Chinese Han patients with newly diagnosed type 2 diabetes mellitus (T2DM). A total of 264 patients was included in this study. Serum 25(OH)D, plasma glucose, serum insulin and other biochemical parameters were assayed. Postprandial venous blood was collected after a mixed-nutrient load. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index (Matsuda ISI). The b-cell function was assessed by the homeostasis model assessment for insulin secretion (HOMA-b) and the change in insulin divided by change in glucose from 0 to 30 min (DI0-30/DG0-30). Patients were divided into three groups according to tertiles of serum 25(OH)D levels. There were significant differences in HOMA-IR and Matsuda ISI among the three groups (HOMA-IR, p50.005; Matsuda ISI, p50.009). Pearson correlation analyses showed that serum 25(OH)D was negatively correlated with fasting serum insulin (FIns) (r520.209, p50.012) and HOMA-IR (r520.273, p50.001), and positively correlated with Matsuda ISI (r50.219, p50.009) only in the male population. Multiple stepwise regression analyses showed that in the male population, serum 25(OH)D was an independent predictor for both HOMA-IR and Matsuda ISI before and after adjustment for confounding factors, respectively (p,0.05 for both). This study indicates the association of vitamin D with insulin resistance in male patients with newly diagnosed T2DM, which may contribute to the understanding of the mechanism underlying the onset of T2DM in the Chinese Han population.

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The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and β-Cell Function in Newly Diagnosed Type 2 Diabetes

Cited by 23 publications

References 24 publications

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Sex-Specific Association of Serum 25-Hydroxyvitamin D<sub>3</sub> with Insulin Resistance in Chinese Han Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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