The relationship between serum 25(OH)D and bone density and microarchitecture as measured by HR-pQCT

Abstract

These data suggest a weak relationship between serum 25(OH)D and bone microarchitecture in this population of mostly vitamin-D-sufficient participants, and there were no indications of negative effects related to the high supplementation levels. These data provided a basis to design and implement our 3-year dose-dependent randomized controlled trial investigating the effects of vitamin D supplementation on bone health outcomes.

Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score

“…However, the link between serum vitamin D and bone microarchitecture has been described as weak. 35 Furthermore, in the study of patients with MACE, 25-hydroxyvitamin D levels were not associated with TBS. 16 Secondly, we were not able to clearly estimate the duration of CS prior to its diagnosis, a parameter that may play a role in the intensity of glucocorticoid-related bone alterations.…”

“…Firstly, it is a retrospective study and confounding osteoporotic factors such as, family background of fractures, smoking status and vitamin D levels that were not accurately recorded may have interfered with our results. However, the link between serum vitamin D and bone microarchitecture has been described as weak . Furthermore, in the study of patients with MACE, 25‐hydroxyvitamin D levels were not associated with TBS .…”

Serum parathyroid hormone is associated with increased cortical porosity of the inner transitional zone at the proximal femur in postmenopausal women: the Tromsø Study

“…Women with 25(OH)D in the upper quartile did not have significantly lower femoral subtrochanteric cortical porosity than did those in the lowest quartile (42.0% vs. 43.0%), in the current study. One reason for this lack of association could be that we included a relatively young (mean age, 68 years) and healthy cohort of postmenopausal women, with serum 25(OH)D mainly in the normal range, similar to the Boyd et al study [26].…”

“…However, few studies have investigated whether vitamin D is associated with bone turnover markers and cortical porosity. One study reported that low serum 25(OH)D is associated with increased cortical porosity in elderly men (mean age, 80 years) [25], whereas 25(OH)D was not associated with cortical porosity in another study of women and men (mean age, 55 years) [26]. In individuals with primary hyperparathyroidism and very high serum parathyroid hormone (PTH) levels, cortical volumetric bone mineral density (BMD) was reduced due to increased cortical porosity.…”

Chinese Women in Both the United States and Hong Kong Have Cortical Microstructural Advantages and More Trabecular Plates Compared With White Women

“…In this study, unfortunately, information about environmental factors such as dietary intake, alcohol consumption, exercise, and smoking, were not acquired for all cohorts and is a limitation, as they may affect bone microstructure. (29)(30)(31)(32)(33)(34) Our prior work in premenopausal women suggests that Chinese-American women tend to have more lifestyle risk factors for poorer skeletal health, including lower calcium and vitamin D intake and exercise levels compared with white women; (10) yet despite this, Chinese-Americans have more favorable microstructure. Adjustment for these covariates in our prior study tended to accentuate the more favorable microstructure in Chinese-Americans.…”