The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender

Elli̇dağ, Hamit Yaşar; Eren, Esin; Akdağ, Mehmet; Giray, Özlem; Kiraz, Kemal; Yılmaz, Necat

doi:10.15407/ubj88.06.076

Cited by 12 publications

(16 citation statements)

References 40 publications

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“…Ferritin levels have been associated with atherogenic lipid profiles in previous studies. It has been reported a negative correlation between levels of serum ferritin and HDL-cholesterol, while positive correlations between levels of serum ferritin and total cholesterol, triglyceride, and LDL-cholesterol 25 . In the present study, for the first time, we demonstrate that ferritin in postmenopausal women participating in RT over 15 weeks was positively correlated with atherogenic lipids including triglycerides, non-HDL and apolipoprotein-B, while negatively correlated with HDL.…”

Section: Discussionmentioning

confidence: 98%

Does resistance training have an effect on levels of ferritin and atherogenic lipids in postmenopausal women? – A pilot trial

Ward

Hammar

Lindh-Åstrand

et al. 2020

Sci Rep

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The objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms. Postmenopausal women enrolled in a randomised controlled trial were allocated to either a sedentary control group (n = 29) or a RT group (n = 26). Blood samples were taken at week-0 and week-15 for all participants. Blood lipids and iron status were measured via routine clinical analyses. Immunoassays were used to measure oxidative stress markers. The RT group, with good compliance, was associated with significant reductions in ferritin, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol. Moreover, ferritin was positively correlated with atherogenic lipids while negatively correlated with high-density lipoprotein in RT women. This occurred without alterations in serum iron, transferrin, transferrin-saturation, C-reactive protein and oxidative stress markers. No differences were found in control women. This study suggests that RT in postmenopausal women both reduces levels of ferritin and counteracts atherogenic lipid profiles independent of an apparent oxidative mechanism. RT may be a beneficial intervention in postmenopausal women via an interaction between ferritin and lipids; however, further investigation in a larger cohort is essential. The risk for cardiovascular disease (CVD) approximately doubles in women during the 10 years after menopause, and physical inactivity contributes to this risk 1,2. The increase in CVD risk is partially attributed to the reduced levels of oestrogens (oestradiol and oestrone) that increase high-density lipoprotein (HDL) levels and decrease low-density lipoprotein (LDL) 3. Oestrogens also increase production of the vasodilator nitric oxide by means of nitric oxide-synthase activation, and possess antioxidant properties reducing levels of reactive oxygen species 3. Oxidative stress levels are a risk factor for CVD and known to be greater in postmenopausal women, compared to women of fertile age, with higher levels of 4-hydroxynonenal (HNE), malondialdehyde, and oxidised LDL 4. In addition, postmenopausal women have an increased body iron burden, in comparison to premenopausal women, that can contribute to iron-driven oxidative stress 5. Ferritin, an iron storage protein, is increased in postmenopausal women and associated with the metabolic syndrome, subclinical coronary atherosclerosis 6 , and carotid atherosclerosis in postmenopausal women 7. Physical inactivity increases the risk for the development of CVD and all-cause mortality in postmenopausal women 8. A comparative study between sedentary postmenopausal women and postmenopausal women who perform regular aerobic exercise showed a significantly lower level of iron burden, including serum ferritin, iron and transferrin saturation, and oxidative stress levels in the active women 9. Aerobic exercise has also shown beneficial effects on lipid profiles in postmenopausal women, with re...

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Section: Discussionmentioning

confidence: 98%

Does resistance training have an effect on levels of ferritin and atherogenic lipids in postmenopausal women? – A pilot trial

Ward

Hammar

Lindh-Åstrand

et al. 2020

Sci Rep

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“…Apo -apolipoprotein triglycerides, as well as LDL, and a negative correlation between ferritin and HDL 130. …”

mentioning

confidence: 89%

“…[125][126][127][128] Recent studies have reported associations between increased ferritin levels and increases in lipids, including total cholesterol, triglycerides, and LDL, in patients with CVD. 129,130 Thus, in the Strength study, we aimed to analyse if RT could alter the plasma lipid profile and iron status in postmenopausal women.…”

Section: Rt Associated Effects On Iron Status and Lipids (Paper Iv)mentioning

confidence: 99%

“…134 However, another RT intervention This study also shows a clear increase in the serum ferritin levels in women with advancing age, albeit still significantly lower than men in all age groups. 130 The molecular mechanisms linking increased iron burden and CVD, or metabolic syndrome, is unclear. However, one of the most probable is the relationship between iron and oxidative stress, with iron being a catalyst for ROS production in atherosclerosis.…”

Section: Rt Associated Effects On Iron Status and Lipids (Paper Iv)mentioning

confidence: 99%

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Sex differences in atherosclerosis and exercise effects

Ward

2019

Linköping University Medical Dissertations

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i Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis being the main cause of cardiovascular diseases. Atherosclerosis is an inflammatory disease of the blood vessel wall, which over time will cause thickening and hardening of the vessel wall. Atherosclerosis can result in catastrophic vascular events, such as myocardial infarction and stroke. There are distinct sex differences in CVD mortality at different ages, before menopause women have a lower mortality of CVD in comparison to men, which equalises after menopause. In addition to sex differences in the incidence of CVD, there are also distinct sex differences in the phenotype of atherosclerotic plaques, with men generally developing more severe and vulnerable plaques that are at risk of rupture.This thesis aimed to investigate the sex differences in atherosclerosis, in particular how the proteome and pathophysiology differs. In addition, we sought to investigate the potential benefit of an exercise programme, in reducing CVD risks, using a randomised controlled trial including postmenopausal women.Sex differences in atherosclerosis were first investigated via proteomic analysis of human carotid endarterectomy samples. Initially, five intraplaque biopsies were taken from distinct atheroma regions, including; internal control, fatty streak, plaque shoulder, plaque centre, and fibrous cap. Protein extracts from these biopsies were subjected to analysis by mass spectrometry. The novel sampling method was successful in reducing the effect of plaque heterogeneity, a limitation in previous proteomic studies of atherosclerosis, and a number of previously unreported proteins were identified in human carotid atheroma. In addition to this, with the inclusion of multivariate statistical modelling, it was found that 43 proteins significantly discriminated the carotid atheroma between men and women. These proteins were grouped by function, and it was found that atheroma from men was associated with the increased abundance of inflammatory response proteins, including phospholipase-A2 membrane associated and lysozyme C, and atheroma from women was associated with increased abundance of blood coagulation, complement activation, and transport proteins, notably including; antithrombin-III, coagulation factor XII, and afamin. In addition, differences were also ii observed in the abundance of iron metabolism related proteins. These sex differences were further expanded upon from a pathophysiological perspective.Immunohistochemistry stainings of ferritin and transferrin receptor 1 were found significantly increased in the atheroma from men. Moreover, the levels of plasma haemoglobin were also significantly increased in men and were associated with the development of more vulnerable and severe plaque types. The more vulnerable and severe plaque types were also associated with significantly greater macrophage infiltration. In summary, these results are indicative of men developing atheroma with greater inflammation that are more vulnerable, due ...

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“…Elevated SF levels are closely related to chronic diseases such as type 2 diabetes (T2D) and cardiovascular disease. Correlation analyses revealed a nega-tive correlation between the levels of SF and high-density lipoprotein cholesterol (HDL-C), while positive correlations existed between the levels of SF and triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) [3].…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Yan

Zhang

et al. 2020

Journal of Diabetes Research

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This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05). But HDL-C was just the opposite (P<0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05). And, HDL-C was just the opposite (P<0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05). But the correlation between LDL-C and ferritin was broken (P>0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.

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The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender

Cited by 12 publications

References 40 publications

Does resistance training have an effect on levels of ferritin and atherogenic lipids in postmenopausal women? – A pilot trial

Does resistance training have an effect on levels of ferritin and atherogenic lipids in postmenopausal women? – A pilot trial

Sex differences in atherosclerosis and exercise effects

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

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