The relationship between serum ferritin concentration and tissue non-heme iron or tissue ferritin in dairy cattle.

Miyata, Yasuyoshi; Furugouri, K.

doi:10.1292/jvms1939.49.1157

Cited by 21 publications

(16 citation statements)

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“…Ferritin is also present in serum and the level of circulating ferritin is directly related to body stores of iron [2,10,15]. Tissue ferritin injected into the vein is rapidly taken up by the liver, in which ferritin receptors are present [1].…”

Section: Discussionmentioning

confidence: 99%

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Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Watanabe

Ozawa

Ochiai

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. Changes in iron and ferritin in calves infected with Theileria sergenti were investigated to elucidate iron metabolism in animals with extravascular hemolytic anemia. During severe anemia, serum iron was remarkably elevated while the total iron-binding capacity remained relatively unchanged or decreased slightly in the infected calves, resulting in elevated transferrin saturation. The serum ferritin concentration gradually increased with the progress of anemia. The erythrocyte ferritin content drastically increased when mean corpuscular volume was elevated. The concentration of non-heme iron and ferritin in the liver, spleen, and bone marrow of the infected calves was markedly higher than that in the respective tissues of the control animals. In particular, the liver of the anemic calves was found to contain 23 and 35 times as much non-heme iron and ferritin, respectively, as that of the non-anemic healthy cattle. The liver type (L) to heart type (H) subunit ratio of liver ferritin was significantly higher in the protozoa-infected than in the non-infected cattle. On the other hand, the L/H ratio of marrow ferritin was significantly reduced by the anemia. These results indicate that the anemic calves infected with T. sergenti apparently present symptoms of iron overload. -KEY WORDS: anemia, calf, ferritin, iron, Theileria sergenti.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, in bovine theileriosis, the excess iron processed by erythrophagocytosis in the liver and spleen may be stored mainly in hepatocytes through such mechanisms as described above. The elevated serum ferritin level in the T. sergenti-infected cattle is considered to reflect apparently increased body iron stores [2,10,15].…”

Section: Discussionmentioning

confidence: 99%

Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Watanabe

Ozawa

Ochiai

et al. 1998

The Journal of Veterinary Medical Science

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“…; Smith et al . ,b; Miyata & Furugouri ; Andrews et al . , ) and is also found in other extracellular fluids, such as milk and synovial and cerebrospinal fluids (Arosio et al .…”

Section: Introductionmentioning

confidence: 99%

Measurement of ferritin and anti‐ferritin autoantibodies in serum and colostrum of Holstein and Japanese Black cows

Kanno

Ohtsuka

Yoshikawa

et al. 2013

Animal Science Journal

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Anti-ferritin autoantibody is a ferritin-binding protein commonly found in mammals; it is thought to form an immune complex with ferritin and thereby mediate the rapid clearance of circulating ferritin. The aim of this study is to determine concentrations of ferritin and anti-ferritin autoantibodies (immunoglobulin (Ig)M, IgG and IgA) in serum and colostrum of Holstein (H) and Japanese Black (JB) cows within 24 h of normal calving. Blood and colostrum samples were collected from cows of various ages (2-11 years) and calving number (1-8 live births). Mean ferritin concentrations were higher in colostrum than in serum for both breeds, and higher colostrum ferritin concentrations were found in H than JB cows. IgA antibodies in serum and colostrum from both breeds had negligible ferritin-binding activity. For both breeds, IgM and IgG antibodies had higher ferritin-binding activity in colostrum than in serum. There was a significant correlation between IgM and IgG ferritin-binding activities in serum and colostrum of H and JB cows. These results suggest that ferritin and IgM and IgG autoantibodies are actively transferred from the blood stream to the colostrum at prepartum or early lactation.

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“…Serum ferritin is present at relatively low concentrations (<1 µg/mL) in various animals including humans and is positively correlated with body iron stores [7][8][9][10][11][12][13]. A variety of ferritin-binding proteins (FBPs) in mammalian circulation systems have been identified: H-kininogen [14], alpha-2-macroglobulin [15,16], autoantibodies [17][18][19][20][21], apolipoprotein B [22] and fibrinogen [23].…”

Section: Introductionmentioning

confidence: 99%

Characterization Analysis of Human Anti-Ferritin Autoantibodies

et al. 2014

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Anti-ferritin autoantibodies are found in many animals. Human ferritin-binding proteins (FBPs) were partially purified from human serum by ion-exchange chromatography and immobilized metal affinity chromatography with Zn 2+ . Crude FBPs were immunocoprecipitated with canine liver ferritin followed by the addition of anti-ferritin antibodies. Immunoglobulins in the immunocoprecipitate were detected with antibodies specific for human IgG, IgM or IgA heavy chains, and immunoglobulins IgG, IgM and IgA to bind to expressed recombinant human H and L chain homopolymers were also found. A portion of human serum proteins bound to zinc ions immobilized on beads were released upon the addition of canine liver ferritin, and the released protein was identified as IgM antibody. Additionally, the released proteins recognized peptide sequence (DPHLCDF) commonly found in amino acid sequences of mammalian ferritin H and L subunits. These results suggest that human serum contains anti-ferritin autoantibodies (IgG, IgM and IgA) which bind zinc ions and preferentially bind ferritin over both the H and L subunits, and that a portion of, but not all, the IgM antibodies bound to ferritin with higher affinity than to zinc ions and may recognize the common sequence found in mammalian ferritin H and L subunits.

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The relationship between serum ferritin concentration and tissue non-heme iron or tissue ferritin in dairy cattle.

Cited by 21 publications

References 0 publications

Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Measurement of ferritin and anti‐ferritin autoantibodies in serum and colostrum of Holstein and Japanese Black cows

Characterization Analysis of Human Anti-Ferritin Autoantibodies

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