The relationship between serum homocysteine levels and sudden sensorineural hearing loss: a meta-analysis

Niu, Xun; Chen, Yuzhang; Zhong, Yi; Xiao, Xi-Yue

doi:10.1007/s00405-023-07829-w

Cited by 1 publication

(2 citation statements)

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“…Niu et al conducted a literature review on the association between SSHL and HCY in 2023 [30]. The study included nine articles and found that serum/plasma concentrations of HCY were higher in SSHL patients than in the control group.…”

Section: Homocysteinementioning

confidence: 99%

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The Role of Fibrinogen, Homocysteine and Metabolic Syndrome’s Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review

Monzani,

Liberale,

Segato

et al. 2023

Medicina

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Fibrinogen and homocysteine (HCY) are molecules known to play a role in vascular homeostasis, and their blood levels are often elevated in patients with metabolic syndrome. Recent evidence suggests that sudden sensorineural hearing loss (SSHL) may have a vascular origin. This has led many authors to advocate that fibrinogen, homocysteine, and metabolic syndrome (MetS) may play a direct role in SSHL. The aim of this brief review is to examine the role and influence of these molecules and MetS on the mechanisms of SSHL. Elevated fibrinogen levels have been associated with a worse prognosis in SSHL, possibly due to increased blood viscosity and decreased blood flow. Similarly, HCY has been associated with vascular damage, particularly in hyperhomocysteinemia, although the exact association with SSHL remains controversial. MetS has been demonstrated to function both as a causative factor and as a contributor to poorer recovery in cases of SSHL. However, although some studies suggest a possible role for these biomarkers and MetS in the prognosis and treatment of SSHL, specific therapeutic and preventive strategies based solely on these factors have yet to be developed. Given their potential role in prognosis and treatment and the global epidemic of metabolic syndrome, this issue needs to be analyzed comprehensively. Thus, further quality studies need to be conducted, even though it is difficult to determine the actual impact of MetS on the development of SSHL, as it is a multifactorial disease affecting multiple organs.

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Section: Homocysteinementioning

confidence: 99%

“…They also suggest that vascular factors could be one of the causes of SSHL. To confirm the theory that hyperhomocysteinemia is a risk factor for SSHL due to vascular damage in the cochlea, further studies on pathophysiology are needed [30].…”

Section: Homocysteinementioning

confidence: 99%