The Relationship between Serum Level  of Vitamin D3 and the Severity of New  Onset Rheumatoid Arthritis Activity

Rajaee, Elham; Ghorbani, Ali; Mowla, Karim; Zakerkish, Mehrnoosh; Mohebi, Maryam; Dargahi-Malamir, Mehrdad

doi:10.7860/jcdr/2017/24014.9486

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…In our study, we also observed a positive association between low vitamin D levels and disease activity in patients with RA. An inverse relationship between vitamin D levels and disease activity has been reported in several previous studies [13,14,16,18]. Similar findings were obtained in Saudi Arabia, where there was a significant negative correlation between vitamin D and disease activity in patients [2,19,22].…”

Section: Discussionsupporting

confidence: 86%

“…RA is caused by both genetic and nongenetic factors, such as hormonal, environmental, and infectious factors. Vitamin D could be an environmental factor, and immunological research has indicated that many chronic and immune disorders are caused by vitamin D deficiency [ 13 , 16 ]. It has been shown that vitamin D affects the innate and adaptive immune systems primarily via toll-like receptors (TLRs) and differentiation of T-cells, predominately Th17 cells, which play an essential role in the pathogenesis of RA [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Deficiency in Saudi Patients With Rheumatoid Arthritis

Alharbi¹,

Alharbi²,

Alhabib³

et al. 2023

Cureus

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Background Epidemiological studies indicate that vitamin D deficiency may increase the risk of developing autoimmune and chronic diseases such as rheumatoid arthritis (RA) and, therefore, is prevalent in patients with RA. Additionally, vitamin D insufficiency is associated with significant disease activity in patients with RA. This study aimed to assess the prevalence of vitamin D deficiency in Saudi patients with RA and determine whether there is an association between low vitamin D levels and RA disease activity. Methodology This cross-sectional retrospective study was conducted from October 2022 to November 2022 on patients who attended the rheumatology clinic at King Salman bin Abdulaziz Medical City, Medina, Saudi Arabia. Patients aged ≥18 years, diagnosed with RA, and not on vitamin D supplements were included. Demographic, clinical, and laboratory data were collected. Disease activity was measured using the disease activity score index of a 28-joint count using the erythrocyte sedimentation rate (DAS28-ESR). Results In total, 103 patients were included, with 79 patients being women (76.7%) and 24 being men (23.3%). The vitamin D level ranged from 5.13 to 94 ng/mL, with a median of 24. Of the studied cases, 42.7% had insufficient vitamin D levels, 22.3% had a deficiency, and 15.5% had severe deficiency. There were statistically significant correlations between the median vitamin D level and C-reactive protein (CRP), the number of swollen joints, and DAS. A lower median vitamin D level was detected among cases with positive CRP, swollen joints >5, and higher disease activity. Conclusions Patients with RA in Saudi Arabia were more likely to have low vitamin D levels. Moreover, vitamin D deficiency was linked to disease activity. Therefore, the measurement of vitamin D levels in patients with RA is essential, and vitamin D supplements might be important to improve disease outcomes and prognoses.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency in Saudi Patients With Rheumatoid Arthritis

Alharbi¹,

Alharbi²,

Alhabib³

et al. 2023

Cureus

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“…A study on a much larger sample size of 894 RA and 861 healthy controls reported an inverse correlation between serum VD levels and RA disease activity [145]. Another study on 93 RA patients and 31 healthy controls from an Iranian population also reported the inverse association between serum VD levels and RA severity and suggested VD supplementation for RA treatment along with other regular medications [146]. A study conducted on the Turkish population reported an inverse relationship between serum VD levels and RA susceptibility but did not find any association between serum VD levels and disease activity [147].…”

Section: Connection Between Vd and Ramentioning

confidence: 99%

Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response

Aslam

John

Bhatti

et al. 2019

BioMed Research International

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Rheumatoid arthritis (RA) is a systemic multifactorial autoimmune disorder. The interactions between diverse environmental and genetic factors lead to the onset of this complex autoimmune disorder. Serum levels of vitamin D (VD) are involved in the regulation of various immune responses. Vitamin D is a key signaling molecule in the human body that maintains calcium as well as phosphate homeostasis. It also regulates the functions of the immune system and, thus, can play a substantial role in the etiology of various autoimmune disorders, including RA. Low serum VD levels have been found to be associated with a higher risk of RA, although this finding has not been replicated consistently. The molecular mechanisms by which VD influences autoimmunity need to be further explored to understand how variation in plasma VD levels could affect the pathogenesis of RA. This mini-review focuses on the influence of VD and its serum levels on RA susceptibility, RA-associated complexities, treatment, and transcriptome products of key proinflammatory cytokines, along with other cytokines that are key regulators of inflammation in rheumatoid joints.

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