The relationship between serum levels of vitamin D with asthma and its symptom severity: A case–control study

Kalmarzi, Rasoul Nasiri; Zamani, Alireza; Fathallahpour, A.; Ghaderi, Ebrahim; Rahehagh, Ramesh; Kooti, Wesam

doi:10.1016/j.aller.2016.04.016

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…Positive conclusions were formulated within a RCT by Arshi et al [ 43 ], as they proved that the supplementation of vitamin D in patients, including adults and adolescents with mild to moderate persistent asthma, significantly improved forced expiratory volume in 1 s (FEV1). It is generally associated with low vitamin D levels in asthmatic patients, which may be improved during supplementation, and as a result, it may enhance asthma control [ 44 ], as the vitamin D status in asthmatic patients is associated with their lung function [ 45 ]. However, other studies did not provide such positive observations, as in children with mild asthma, no effect of supplementation of vitamin D on airway reactivity and inflammation was stated [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

et al. 2023

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Vitamin D is indicated to be beneficial for the prevention and treatment of both respiratory health and mental health problems, while mental health issues are a common consequence of diseases of the respiratory system. The aim of the presented systematic review was to gather available evidence regarding the influence of the supplementation of vitamin D on mental health in adults with respiratory system diseases obtained within randomized controlled trials (RCTs). The systematic review was conducted on the basis of the PubMed and Web of Science databases in agreement with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), while being registered within the database of the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42020155779). A total of 8514 studies published before September 2021 were screened and 5 RCTs were included, which were assessed using the revised Cochrane risk-of-bias tool for randomized trials. Screening, inclusion, reporting, and assessment were conducted by two researchers independently. The studies focused on the assessment of patients with chronic obstructive pulmonary disease, but also increased susceptibility to respiratory tract infections, pulmonary tuberculosis, and bronchial asthma. The studies were conducted for various periods of time—from 2 months to a year—while the dose of vitamin D applied was also diverse—from 4000 IU applied daily, to 100,000 IU applied weekly, or monthly. The psychological measures applied within the studies allowed the assessment, mainly, of quality of life, but also well-being, and depression. For the majority of studies, some concerns regarding risk of bias were defined, resulting from the randomization process and selection of reported results; however, for one study, the risk was even defined as high. Within the included studies, three studies confirmed a beneficial effect of vitamin D (including those with a high risk of bias), but two studies did not confirm it. Taking into account the evidence gathered, in spite of a positive influence of vitamin D on mental health in individuals with increased susceptibility to respiratory tract infections and bronchial asthma, the conducted systematic review is not a strong confirmation of the beneficial effect of the supplementation of vitamin D on mental health in adults with respiratory system diseases.

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Section: Discussionmentioning

confidence: 99%

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

et al. 2023

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“…Although asthma is a heterogeneous disorder and is influenced by many immunological factors, growing evidence has linked vitamin D with asthma pathogenesis 44 . This connection may be explained by the presence of abundant vitamin D receptors in airway tissue as well as the known existence of vitamin D receptor polymorphisms 45 , 46 .…”

Section: Discussionmentioning

confidence: 99%

Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study

Alkhatatbeh

Almomani

Abdul‐Razzak

et al. 2021

npj Prim. Care Respir. Med.

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There are complex potential inter-relationships between the chronic inflammation of asthma and poor control, vitamin D deficiency, musculoskeletal pain and anxiety and depression. The aim was to investigate associations between vitamin D and these possible co-morbidities. This case-controlled study involved 75 adults with asthma and 75 controls. Serum 25-hydroxyvitamin D (25(OH)D) was measured, levels of anxiety, depression, musculoskeletal pain, and asthma control were assessed. Participants with asthma had lower 25(OH)D and higher anxiety scores and higher measures of musculoskeletal pain compared to controls. Binary logistic regression showed that asthma was associated with decreased 25(OH)D (Odds ratio (OR) = 0.86), general weakness (OR = 13.29), complaint of musculoskeletal pain (OR = 13.73), and increased intensity of musculoskeletal pain (OR = 0.61) and number of painful sites (OR = 2.58). Asthma was not associated with anxiety or depression. Further studies are required to investigate if vitamin D supplementation can improve asthma symptoms and musculoskeletal pain.

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Serum levels of adiponectin and leptin in asthmatic patients and its relation with asthma severity, lung function and BMI

Kalmarzi

Ataee

Mansori

et al. 2017

Allergologia et Immunopathologia

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The relationship between serum levels of vitamin D with asthma and its symptom severity: A case–control study

Abstract: The results showed that serum levels of vitamin D in asthma patients were less than in healthy people, and also reduced lung function in these patients. So, the serum levels of vitamin D in asthma patients must be checked continuously.

Cited by 9 publications

References 40 publications

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study

Serum levels of adiponectin and leptin in asthmatic patients and its relation with asthma severity, lung function and BMI

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