The Relationship Between Serum Lipoprotein(a) and Insulinemia in Healthy Nondiabetic Adult Men

Pb, Duell; Hagemenas, F. C.; Connor, W E

doi:10.2337/diacare.17.10.1135

Cited by 23 publications

(13 citation statements)

References 46 publications

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“…In a previous study, univariate regression analysis revealed a significantly nega-tive correlation (r = -0.339) between the fasting serum concentrations of insulin and log-transformed Lp(a) in 54 nondiabetic adult men (32). The same method of analysis in the present study yielded a correlation that was not significant and clearly lower than that found in this previous study in both sexes.…”

Section: Table 3-correlations Between Lp(a) and Atherosclerotic Factorscontrasting

confidence: 73%

“…A positive correlation between Lp(a) and age (44) and between Lp(a) and LDL cholesterol (32), as well as an inverse cor-relation between Lp(a) and triglycerides (44)(45)(46) and between Lp(a) and BMI (32,45), have been reported. Correlations between Lp(a) and fibrinogen and between Lp(a) and coagulation factor VII were reported in our previous study (35).…”

Section: Table 3-correlations Between Lp(a) and Atherosclerotic Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Serum Insulin and Lipoprotein(a) Concentrations: The Jichi Medical School Cohort Study

Inoue

Nago²,

Matsuo³

et al. 1997

Diabetes Care

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Section: Table 3-correlations Between Lp(a) and Atherosclerotic Factorscontrasting

confidence: 73%

Section: Table 3-correlations Between Lp(a) and Atherosclerotic Factorsmentioning

confidence: 99%

Serum Insulin and Lipoprotein(a) Concentrations: The Jichi Medical School Cohort Study

Inoue

Nago²,

Matsuo³

et al. 1997

Diabetes Care

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show abstract

“…In 1 study, Lp(a) levels were lower in subjects with hyperinsulinemia, 23 but in other studies, 24,25 no significant relation of Lp(a) to insulin was found. However, apo(a) phenotypes were not determined in these studies.…”

mentioning

confidence: 75%

Insulin and 2-Hour Glucose Levels Are Inversely Related to Lp(a) Concentrations Controlled for LPA Genotype

Rainwater

Haffner

1998

ATVB

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Abstract-In this study we assessed the relationship of lipoprotein(a) [Lp(a)] with diabetes status and with measures of glucose and insulin in a population of Mexican Americans having a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM). Because of enormous allelic diversity at LPA [the locus encoding the apo(a) protein] that directly influences Lp(a) concentrations, it was first necessary to adjust for the large effects of variation at LPA. We calculated residual Lp(a) concentration as the difference between observed and expected; expected Lp(a) concentration was based on information from all family members sharing each identical-by-descent (IBD) allele. We found significant effects of sex and age on residual Lp(a) concentrations that increased with age (Pϭ0.0004) and in females (Pϭ0.0034). Although diabetes status per se was not related to residual Lp(a) concentrations (Pϭ0.097), we found that residual Lp(a) concentrations were inversely correlated with fasting insulin (Pϭ0.0017) and with insulin (Pϭ0.0028) and glucose (Pϭ0.0429) concentrations measured 2 hours after a glucose challenge. Furthermore, significant inverse correlations with the 2 insulin measures were observed for a subgroup of nondiabetic individuals. Inclusion of 2 lipid measures (plasma concentrations of cholesterol and triglycerides) in the models showed that the correlations with insulin and glucose were independent of the relationship between Lp(a) concentrations and the lipid measures. Also, we determined the residual size for each apo(a) isoform by adjusting for the IBD isoform group average. Although not related to diabetes status, residual apo(a) isoform size was positively correlated with fasting insulin (Pϭ0.0013) and with 2-hour glucose (Pϭ0.0246) and 2-hour insulin (Pϭ0.0182) concentrations. In addition, significant correlations for all 4 measures were found for the subgroup of nondiabetic individuals.

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“…In a very early study performed on type 1 diabetes patients, improvement in metabolic control by insulin therapy significantly lowered Lp(a) level [22]. Some later studies suggested an inverse association of circulating insulin level and Lp(a) in patients with type 2 diabetes, and also in healthy subjects [23–25]. However, Lp(a) did not show significant differences in children with type 1 diabetes mellitus compared with non-diabetic controls, opposing a direct association of endogenous insulin level and Lp(a) [26].…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance contributes more to the increased risk for diabetes development in subjects with low lipoprotein(a) level than insulin secretion

et al. 2017

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BackgroundRecent studies suggest an association between Lipoprotein(a) [Lp(a)] and the development of diabetes mellitus. We analyzed the association between baseline Lp(a) levels and diabetes development after 4 years of follow-up, in a population of apparently healthy Korean subjects.MethodsA total of 2,536 non-diabetic participants (mean age: 41 years, men: 92%) of a health checkup program were included in the study. Diabetes development was defined by fasting blood glucose ≥126 mg/dL, HbA1c ≥6.5%, and self-reported treatment of diabetes. Homeostasis model assessment (HOMA) indices were used to assess insulin resistance (IR) and insulin secretion (IS). Presence of IR and impaired IS was defined by being in the highest quartile of HOMA-IR and in the lowest quartile HOMA-IS.ResultsAfter four years, 3.4% of the participants developed diabetes. The odds ratio (OR) of developing diabetes was lowest in the 4th quartile group of baseline Lp(a) (0.323 [95% CI 0.153–0.685])with the 1st quartile group as the reference. The subjects with both IR & impaired IS plus baseline Lp(a)<50 mg/dL showed the higher OR for diabetes development compared with those without IR and normal IS as the reference (67.277 [20.218–223.871], and those with IR plus Lp(a)<50 mg/dL showed higher OR for diabetes than in those with impaired IS and Lp(a)<50 mg/dL (3.811 [1.938–7.495] vs. 3.452 [1.620–7.353]).ConclusionsThe subjects with low baseline Lp(a) level showed higher risk for development of diabetes compared with high baseline Lp(a) level, and this was prominent in those with IR than in those with impaired IS.

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The Relationship Between Serum Lipoprotein(a) and Insulinemia in Healthy Nondiabetic Adult Men

Cited by 23 publications

References 46 publications

Serum Insulin and Lipoprotein(a) Concentrations: The Jichi Medical School Cohort Study

Serum Insulin and Lipoprotein(a) Concentrations: The Jichi Medical School Cohort Study

Insulin and 2-Hour Glucose Levels Are Inversely Related to Lp(a) Concentrations Controlled for LPA Genotype

Insulin resistance contributes more to the increased risk for diabetes development in subjects with low lipoprotein(a) level than insulin secretion

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