The Relationship Between Serum Mannose-Binding Lectin Levels and Acute Ischemic Stroke Risk

Abstract

Complement activation and inflammation have been suggested in the pathogenesis of stroke, mannose-binding lectin (MBL) were found to have roles during the process. The aim of this study was to investigate the relationship between acute ischemic stroke (AIS) and serum MBL levels in Chinese population. From January 1 to June 30 2013, all patients with first-ever AIS were recruited to participate in the study. Serum MBL levels and routine test were examined. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to MBL levels. During the inclusion period, 148 patients with AIS were registered and completed study. The results indicated that the serum MBL levels were significantly (p < 0.0001) higher in acutely ischemic stroke patients as compared to normal controls [1,332; interquartile range (IQR) 996-2,134 μg/L and 897; IQR 678-1,100 μg/L, respectively]. There was a correlation between serum levels of MBL and NIHSS score [r (spearman) = 0.608, p < 0.0001). In multivariate analysis, serum MBL as a continuous variable was associated with an increased risk of AIS, after adjustment for above possible confounders (OR 1.002, 95 % CI 1.001-1.008; p < 0.0001). These results indicated that elevated MBL levels could be considered as an independent stroke risk factor in Chinese population, suggesting a role of MBL and the lectin pathway of complement activation in the pathogenesis of stroke.

Serum protein biomarkers screening in patients with ischemic stroke by LC-MS/MS

“…An independent association between variant MBL2 genotypes and coronary artery disease (CAD) was previously confirmed in the American Indian, Strong Heart Study (SHS) cohort (OR = 3.2, 95% CI 1.5-7.0, p =0.004, adjusted for 11 CAD covariates) [31]. Osthoff et al [32] reported that MBL deficiency is associated with smaller cerebral infarcts and favorable outcome in ischemic stroke patients receiving conservative treatment, while Wang et al [33] found that elevated MBL levels could be considered as an independent stroke risk factor, suggesting a role of MBL and the lectin pathway of complement activation in the pathogenesis of stroke.…”

Mannan-Binding Lectin in Cardiovascular Disease

“…In a recent clinical study Wang et al [55] assessed serum levels of MBL in 148 Chinese patients with acute ischaemic stroke (the blood samples were obtained within 24 hours from recognition). MBL levels were significantly higher in stroke patients compared with healthy controls and increased with increasing severity of stroke.…”

MBL2 gene polymorphisms increase the risk of adverse neurological outcome in preterm infants: a preliminary prospective study

“…In the case of tissue damage, MBL rapidly deposits on target cells and triggers downstream complement activation in the acute phase, enhancing the cleavage of C3 (9). In patients in the acute phase of the stroke, MBL seems to contribute to inflammatory cerebral injury as well as to play a direct role in stroke recovery (10,11). Furthermore, several studies in animal models have shown that MBL-mRNA is expressed in brain tissue (12) and the lectin pathway is central to the propagation of ischemia-reperfusion injury across a variety of tissues (13,14).…”