The Relationship between Serum Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index with Severity Levels of Gastroesophageal Reflux Disease: A Literature Review

Abstract

Gastroesophageal reflux disease (GERD) is a global health problem in which the prevalence is increasing over periods. This disease is a significant cause of disorders in the upper gastrointestinal tract with very complex pathogenesis. Oxidative stress (OS) due to gastric acid reflux plays a role in the inflammatory response of the esophageal epithelium. Several OS markers have been widely studied and are thought to affect the severity degree of the esophageal mucosa. However, there has been no research on total oxidant status (TOS), total antioxidant status (TAS), and OS index (OSI) in the adult with GERD; hence the aim of this review was to determine the association between TOS, serum TAS, and OSI with the GERD degree. A literature review was conducted by searching articles related to the TOS, TAS, OSI, and its correlation with GERD degree on an online database, particularly Pubmed and Google scholar. We conclude that TAS and OSI might influence the severity of GERD; however, further clinical study is needed to prove this theory.

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

“…[52] The increase in TOC values and the decrease in TAC values indicate oxidative stress or increased susceptibility to oxidative damage. [53] TOC values increased significantly while TAC values decreased in the salivary glands of group VA of this study. This phenomenon has also been reported in various tissue types exposed to VA in other studies.…”

“…While TOC provides information about the level of oxidants and ROS in a biological sample, TAC is used to measure the total antioxidant status [52] . The increase in TOC values and the decrease in TAC values indicate oxidative stress or increased susceptibility to oxidative damage [53] . TOC values increased significantly while TAC values decreased in the salivary glands of group VA of this study.…”

Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial

“…The change in STAS, the estimation of the global antioxidant rate [37], was significantly higher in the test group compared with that of the control group during the test period.…”