The relationship between serum trace elements, vitamin B12, folic acid and clinical parameters in patients with myofascial pain syndrome

Okumuş, Müyesser; Ceceli, Esma; Tuncay, Figen; Kocaoğlu, Seher; Palulu, N.; Yorgancioğlu, Z. Rezan

doi:10.3233/bmr-2010-0264

Cited by 22 publications

(11 citation statements)

References 51 publications

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“…Vitamin deficiency has been directly linked to the pathophysiology of several chronic non-communicable musculoskeletal diseases, including osteoporosis, myofascial pain syndrome, chronic fatigue syndrome, myositis, and FM 10,27,28,29,30 .…”

Section: Discussion I Vitamin Deficiency In Fibromyalgiamentioning

confidence: 99%

“…Recent studies have indicated vitamin D deficiency as the main trigger factor for diseases related to chronic diffused pain, myofascial pain, joint pain, muscle weakness and fatigue 10,11,30,31 . According to Schinchuk and Holick 28 , vitamin D deficiency causes osteopenia, and it precipitates and exacerbates osteoporosis, leading to osteomalacia, a painful bone disease.…”

Section: Discussion I Vitamin Deficiency In Fibromyalgiamentioning

confidence: 99%

“…Some studies have demonstrated an association between low levels of vitamin D and diffuse musculoskeletal pain, including FM, although the results appear inconclusive. In addition, reduced serum levels of zinc (Zn), magnesium (Mg), calcium (Ca), copper (Cu), iron (Fe) and manganese (Mn) have been observed among FM patients and are related to clinical symptoms such as fatigue, weakness and cognitive impairments 10,11,12,13 .…”

Section: Introductionmentioning

confidence: 99%

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El hambre oculta y la fibromialgia: Una revisión sistemática

2019

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RESUMEN Recientemente há sido discutida la posibilidad de una relación causal entre la fibromialgia (FM) y la deficiencia de micronutrientes, un tipo de deficiencia nutricional conocida como "hambre oculta". Sin embargo, los estudios son pocos y los resultados controversiales, lo que genera debates sobre la influencia real del "hambre oculta" en el proceso de la enfermedad en las personas con fibromialgia. En está revisión se presentan y discuten evidencias científicas relacionadas con la deficiencia de micronutrientes y FM, destacando los principales micronutrientes relacionados. El levantamiento de información fue realizado en los bases de datos de PubMed y Science Direct en estudios observacionales publicados entre los años 2000 y 2017. Fueron seleccionados 14 estudios, ocho dirigidos a la asociación

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Section: Discussion I Vitamin Deficiency In Fibromyalgiamentioning

confidence: 99%

Section: Discussion I Vitamin Deficiency In Fibromyalgiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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El hambre oculta y la fibromialgia: Una revisión sistemática

2019

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“…In addition to the basic science studies presented, multiple clinical studies have aimed to uncover the relationship between serum trace metal concentrations and the incidence of pain. More specifically, multiple studies have found an inverse correlation between the pain associated with a variety of diseases, such as fibromyalgia and myofascial pain syndrome, and the concentration of serum zinc [ 47 , 48 ]. In each of these studies, the severity of the disease was characterized using a variety of clinical features, such as the number of tender points and extent of fatigue or pain pressure thresholds, in individuals suffering from fibromyalgia and myofascial pain syndrome respectively.…”

Section: Clinical Studies Supporting the Role Of Trace Metals In Nocimentioning

confidence: 99%

Redox and trace metal regulation of ion channels in the pain pathway

Evans

Todorović

2015

Biochemical Journal

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Given the clinical significance of pain disorders and the relative ineffectiveness of current therapeutics, it is important to identify alternative means of modulating nociception. The most obvious pharmacological targets are the ion channels that facilitate nervous transmission from pain sensors in the periphery to the processing regions within the brain and spinal cord. In order to design effective pharmacological tools for this purpose, however, it is first necessary to understand how these channels are regulated. A growing area of research involves the investigation of the role that trace metals and endogenous redox agents play in modulating the activity of a diverse group of ion channels within the pain pathway. In the present review, the most recent literature concerning trace metal and redox regulation of T-type calcium channels, NMDA (N-methyl-D-aspartate) receptors, GABAA (γ-aminobutyric acid A) receptors and TRP (transient receptor potential) channels are described to gain a comprehensive understanding of the current state of the field as well as to provide a basis for future thought and experimentation.

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“…The influence of antioxidants on painful nociception and the reduction of damage caused by free radicals in patients with chronic musculoskeletal pain are controversial [ 15 ][ 16 ][ 17 ][ 18 ]. A body of evidences suggests that deficiencies of selenium (Se) and zinc (Zn) participate in the pathophysiological process of painful musculoskeletal disease, which is associated with the presence of pain and other clinical manifestations [ 17 ][ 18 ][ 19 ][ 20 ][ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium and Zinc Status in Chronic Myofascial Pain: Serum and Erythrocyte Concentrations and Food Intake

Neto¹,

Souza‐Machado²,

Kraychete³

et al. 2016

PLoS ONE

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IntroductionNutritional disorders have been reported to be important causal factors that can intensify or cause a painful response in individuals with chronic musculoskeletal pain.AimTo assess the habitual intake of and the serum and erythrocyte levels of selenium and zinc in patients with chronic myofascial pain.Materials and MethodsA case-control study of 31 patients with chronic myofascial pain (group I) and 31 subjects without pain (group II). Dietary record in five days for assessing food intake were used. The serum and erythrocyte concentrations of selenium and zinc were analyzed using an atomic absorption spectrophotometry. Pain intensity was assessed using a visual analog scale.ResultsThe group of patients with chronic myofascial pain, compared with the control group, showed a lower erythrocyte concentration of selenium (79.46 ± 19.79 μg/L vs. 90.80 ± 23.12 μg/L; p = 0.041) and zinc (30.56 ± 7.74 μgZn/gHb vs. 38.48 ± 14.86 μgZn/gHb, respectively; p = 0.004). In this study, a compromised food intake of zinc was observed in the majority of the subjects in both groups. The selenium intake was considered to be safe in 80% of the subjects in both groups; however, the likelihood of inadequate intake of this mineral was twice as high in group I (49.5% vs. 24.4%, respectively). In the logistic regression analysis, the erythrocyte concentration of zinc was associated with the presence of pain. In each additional 1 mg of Zn2+ per gram of hemoglobin, a reduction of 12.5% was observed in the risk of the individual having chronic myofascial pain (B = -0.133; adjusted OR = 0.875, 95% CI = 0.803 to 0.954, Wald = 9.187, standard error = 0.044, p = 0.002). Physical inactivity and obesity were noted more commonly in group I compared with the control group.ConclusionIn this study, patients with chronic myofascial pain showed lower intracellular stores of zinc and selenium and inadequate food intake of these nutrients.

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The relationship between serum trace elements, vitamin B12, folic acid and clinical parameters in patients with myofascial pain syndrome

Abstract: According to the results of this study, it was asserted that trace elements, vitamins may play an important role in the pathophysiology of MPS and psychological factors may also have additional effect.

Cited by 22 publications

References 51 publications

El hambre oculta y la fibromialgia: Una revisión sistemática

El hambre oculta y la fibromialgia: Una revisión sistemática

Redox and trace metal regulation of ion channels in the pain pathway

Selenium and Zinc Status in Chronic Myofascial Pain: Serum and Erythrocyte Concentrations and Food Intake

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