The relationship between skin function, barrier properties, and body‐dependent factors

Dąbrowska, Agnieszka; Spano, Fabrizio; Derler, S.; Adlhart, Christian; Spencer, Nicholas D.

doi:10.1111/srt.12424

Cited by 300 publications

(211 citation statements)

References 100 publications

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“…The skin is the largest organ in the human body in terms of body weight and it plays an important role, not only in its shield-like external defense function but also in the regulation of temperature and water. 1,2 Being the outermost layer of the body, the presence of skin protects the rest of the body from Zihan Zhao is presently a postgraduate student in Tongji University and her research interests are inammatory skin diseases especially psoriasis, microneedles, and nano-carrier. She has published 3 papers in SCI journals.…”

Section: Introductionmentioning

confidence: 99%

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

2020

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Section: Introductionmentioning

confidence: 99%

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

2020

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“…At the same time, it is easily damaged when stimulated by external chemical and physical factors. Full-thickness skin wounds caused by varicose veins, arterial occlusion, burns, car accident injuries, war injuries, avulsion injuries and other traumas are the most common conditions in clinical emergency departments and have always posed di cult problems for clinicians [1][2]. In patients with full-thickness skin defects, the wounds are healed mainly by the migration of stem cells adjacent to the skin epithelial cells and regeneration of the remaining skin appendages.…”

Section: Introductionmentioning

confidence: 99%

Rat epidermal stem cells promote the angiogenesis of full-thickness wound

Huang

Wang

et al. 2020

Preprint

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Abstract Background: Full-thickness wounds severely affect patients’ life quality and become challenging problems for clinicians. Stem cells have great prospects in the treatment of wounds. Our previous study confirmed that autologous basal cell suspension could promote wound healing, and epidermal stem cells (ESCs) were detected in the basal cell suspension. Herein, this study aimed to explore the effect of ESCs on full-thickness wounds. Methods: Rat ESCs were isolated and expanded, and then were transfected with lentivirus to stably express enhanced green fluorescent protein. The experimental rats were randomly divided into 2 groups: in the ESC group, the rat ESCs were sprayed on the full-thickness wounds of rats; in the control group, phosphate-buffered saline was sprayed the on the wounds. Next, wound healing and neovascularization were evaluated. Colonization, division and differentiation of ESCs on the wound were analyzed by immunofluorescence. Results: The rat ESCs colonized, divided and proliferated in the wound. Additionally, rat ESCs around blood vessels differentiated into vascular endothelial cells and formed a lumen-like structure. Compared with the control group, the ESC group showed enhanced angiogenesis and accelerated wound healing. Conclusions: Our study confirmed that rat ESCs are safe and effective for treating full-thickness wounds . Additionally, under certain conditions, ESCs can differentiate into vascular endothelial cells to promote angiogenesis and wound healing.

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“…In contrast, the skin on the arms and legs, which is thicker, contains fewer sebaceous glands and has slower epidermal turnover than the face and is therefore prone to dryness, scaling, and crepiness . Consequently, skin on the limbs benefits from ceramides, oil‐rich occlusion, and small peptides that restore barrier function and boost collagen production .…”

Section: Introductionmentioning

confidence: 99%

Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas

Falla¹,

Rodan

Fields

et al. 2019

J of Cosmetic Dermatology

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Background: Hydration and moisturization both impact skin quality, directly reflecting its appearance. Signs and onset of dehydration-related skin aging are region-specific and require tailored treatment to be effective. Aims:To test the hydrating effects of formulas containing a novel 3-dimensional 3polymer interpenetrating network (3D3P-IPN) to deliver humectants and actives to specific body sites. Methods:Two clinical studies were conducted focused on the skin under eyes and body (arms/legs). Healthy women ages 25-65 (eyes) or 35-65 (body) with mild to moderate dry and aged skin were enrolled. Study product containing the 3D3P-IPN and tailored actives was applied twice daily for 8 weeks on the periorbital area and for 4 weeks on the body. Changes in skin attributes were measured by biophysical instrumentation for hydration, dark circles, skin color, elasticity and transepidermal water loss, and by clinical grading and subject self-assessment.Results: Significant improvements in hydration and skin smoothing were demonstrated in both studies. In the periorbital region, actives and humectants delivered by the 3D3P-IPN also led to significant improvements in dark circles, fine lines/crow's feet, puffiness, restoring radiance, and overall younger-looking appearance. On the arms and legs, there were significant reductions in crepiness and dullness. The arms and legs also had improvements in tactile and visual skin texture, radiance, and general healthy look. Improvements were immediate and persisted through the end of both studies. Conclusion:The 3D3P-IPN provides immediate and long-lasting improvements in skin hydration and overall healthy appearance regardless of the targeted application site. K E Y W O R D Sinterpenetrating polymer network, skin hydration, TIVI, under-eye circles This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The relationship between skin function, barrier properties, and body‐dependent factors

Abstract: Background: Skin is a multilayer interface between the body and the environment,

Cited by 300 publications

References 100 publications

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis

Rat epidermal stem cells promote the angiogenesis of full-thickness wound

Novel interpenetrating polymer network provides significant and long‐lasting improvements in hydration to the skin from different body areas

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