The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

Abstract

Background: Pediatric patients with inflammatory bowel disease (IBD) are at risk for psychiatric symptoms that impact quality of life (QoL) and psychosocial functioning. Sleep disturbance has been reported to impose adverse effects on host defense mechanisms by affecting the magnitude and characteristics of the inflammatory response. The current study sought to assess the relationships among sleep disturbance, QoL, and psychosocial functioning in children with IBD. Methods: Pediatric IBD patients completed multiple measures of sleep and daytime functioning as well as measures of QoL and psychosocial functioning. The parents completed complementary measures of sleep, QoL, and psychosocial functioning. The HRQOL results for subjects with IBD were compared to a healthy control group. Results: Fifty-three children with pediatric IBD and their parents were enrolled in the study. QoL was positively associated with sleep quality, based on significant negative correlations between QoL and both sleep quality and daytime sleepiness scales (r = −0.62, −0.57; p value <0.001, respectively). Patients with CD reported significantly better QoL and psychosocial functioning than patients with UC. The QoL was similar between IBD patients and healthy controls. Conclusions: The present study suggests that a positive association exists between sleep functioning and QoL in pediatric patients with IBD. Patients with pediatric IBD should be screened for sleep disturbance, QoL and psychosocial functioning. Prevention and intervention strategies of sleep disturbance aimed at improving QoL and psychosocial functioning in children with IBD should be developed and evaluated.

Development of a Quality-of-Life Survey for Patients With Succinic Semialdehyde Dehydrogenase Deficiency, a Rare Disorder of GABA Metabolism

“…Previous studies have demonstrated quality of life is negatively impacted in children with conditions and symptoms associated with SSADHD, including developmental delays, 4 epilepsy, 5 and sleep disturbances. 6 To date, however, there are no current research studies evaluating quality of life specifically in SSADHD.…”

Differential Sleep Traits Have No Causal Effect on Inflammatory Bowel Diseases: A Mendelian Randomization Study

“…Animal studies showed that sleep disorders promoted colonic inflammation and worsened the severity of colitis ( Preuss et al, 2008 ; Tang et al, 2009 ). Clinical studies showed a correlation of sleep disorders with IBD, in which a significant decrease in sleeping time and sleeping efficiency was closely related to the development and disease activity of IBD ( Chakradeo et al, 2018 ; Chrobak et al, 2018 ; Jarasvaraparn et al, 2019 ; Marinelli et al, 2020 ). A recent systematic review and meta-analysis confirmed the association between poor sleep quality and increased risk of IBD activity ( Hao et al, 2020 ).…”

Who sleeps better? Sleep patterns and sleep disturbances in adolescents with recurrent abdominal pain or inflammatory bowel disease and healthy controls

“…Our results concerning sleep quality in IBD patients are in line with former studies. Especially impairments regarding overall sleep quality and sleep disturbances in IBD patients have been shown for adults as well as for children and adolescents [28,[42][43][44][45][46]. However, Pirinen and colleagues (2010) revealed that significantly more adolescents with IBD (25%) had sleep problems than the control group (13%), according to parental report, whereas the adolescents themselves did not report elevated sleep difficulties [32].…”