The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy

Romero, Roberto; Baumann, P.; Gómez, Ricardo; Salafia, Carolyn; Rittenhouse, Linda; Barberio, D.; Behnke, Ernesto; Mitchell, Mark E.

doi:10.1016/0020-7292(94)90208-9

Cited by 25 publications

(29 citation statements)

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“…Since collection of serum is easier than collection of amniotic fluid, our study attempted to evaluate the correlation between PGE 2 levels in GCF and serum. Another study has demonstrated a positive correlation between IL-6 levels in maternal serum and amniotic fluid during the second trimester (20), suggesting that changes in the levels of inflammatory mediators in amniotic fluid reflect those in serum. As there are no published reports of the correlation between levels of PGE 2 in serum and GCF during pregnancy, our present results were compared with those of investigations that had assessed the correlation between GCF-PGE 2 and amniotic PGE 2 levels.…”

Section: Discussionmentioning

confidence: 98%

Gingival crevicular fluid prostaglandin E2 level as a predictor of preterm low birth weight: a pilot investigation

2011

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Periodontal infections, which serveas a reservoir of inflammatory mediators such as prostaglandin E 2 (PGE 2 ), may pose a threat to the fetal-placental unit and cause preterm delivery. This study was conducted to estimate the levels of PGE 2 in gingival crevicular fluid (GCF) and serum to explore the possible use of the GCF-PGE 2 level as a risk predictor of preterm low birth weight (PLBW). Twenty-two pregnant female patients were selected for the study. Samples of GCF and serum were collected from each patient, and sampling was repeated at one month after parturition. The level of PGE 2 in GCF and serum was estimated using a commercially available ELISA kit (NeogenTM). The mean serum PGE 2 level was 4.4 ng/ml and 1.64 ng/ml before and after parturition, respectively, and the difference was statistically significant (P < 0.001). The mean GCF-PGE 2 level was 5.8 ng/ml and 5.5 ng/ml before and after parturition, respectively, but the difference was not significant. There was positive correlation between the serum-PGE 2 and GCF-PGE 2 levels, and there was a negative correlation between PGE 2 level and gestational age. The present findings suggest that there is a weak correlation between maternal GCF-PGE 2 level and birth outcome. Further clinical trials with a larger sample size are warranted for further investigation of the association between GCF-PGE 2 level and PLBW. (J Oral Sci 53, 293-300, 2011)

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Section: Discussionmentioning

confidence: 98%

Gingival crevicular fluid prostaglandin E2 level as a predictor of preterm low birth weight: a pilot investigation

2011

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“…Infection during pregnancy further elevates the levels of these cytokines in amniotic fluid, FM and decidua . This fact holds well even in preterm deliveries (compared to term) especially with infection and PPROM (Cox et al, 1997;Maymon et al, 1999;Romero et al, 1988Romero et al, & 1993. The source of these cytokines is the infiltrating leucocytes as demonstrated by immunolocalization studies of gestational tissues (Young et al, 2002).…”

Section: Inflammation/infection Induced Fm Weakeningmentioning

confidence: 91%

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

Rangaswamy¹,

Kumar²,

Moore³

et al. 2012

Preterm Birth - Mother and Child

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“…The biological mechanisms involve bacterially induced activation of cell-mediated immunity leading to cytokine production and the ensuing synthesis and release of PG, which appears to trigger preterm labor (59). Elevated levels of cytokines (IL-1, IL-6, and TNF-␣) have been found in the amniotic fluid of patients in preterm labor with amniotic fluid infection (118). These cytokines are all potent inducers of both PG synthesis and labor.…”

Section: Low Birth Weightmentioning

confidence: 99%