The relationship between stress and clinical outcomes for persons living with HIV/AIDS: a systematic review of the global literature

Weinstein, Traci L.; Li, Xiaoming

doi:10.1080/09540121.2015.1090532

Cited by 37 publications

(32 citation statements)

References 43 publications

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“…Given the negative impact of PTSD on progression of HIV infection, access to care and treatment adherence (17–20), the occurrence of PTSD symptoms is threatening PLHA’s quality of life in rural China. Thus, screening and management of PTSD and other mental health problems is essential and should be integrated into current HIV-related healthcare services.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, PLHA are more likely than other individuals to experience other traumatic events, such as physical violence and sexual assault, which place them at risk of developing PTSD (3,16). Moreover, the presence of mental health problems such as PTSD symptoms may lead to the faster progression of HIV infection, worse physical problems, social phobia, and poor adherence to medication (1,11,17–20). …”

Section: Introductionmentioning

confidence: 99%

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Post-traumatic Stress Disorder Symptoms Among People Living with HIV/AIDS in Rural China

Luo

Lin

et al. 2016

AIDS Behav

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Among people living with HIV/AIDS (PLHA), the occurrence of post-traumatic stress disorder (PTSD) symptoms associated with HIV diagnosis is a common problem. This study examined HIV diagnosis-related PTSD symptoms and its associated factors among PLHA in rural China. We used baseline data from a randomized controlled trial conducted in Anhui Province, China. Surveys of 522 PLHA were conducted via computer-assisted personal interview method. PTSD symptoms were measured based on re-experiencing, avoidance and arousal of the day of HIV diagnosis. Association between PTSD symptoms and demographic characteristics, physical and social functioning were assessed by multiple regression analysis and structural equation modeling. Social functioning exhibited a direct association with HIV diagnosisrelated PTSD symptoms, and also mediated the association between PTSD symptoms and age, family income, and physical functioning. The study findings underscore the importance of developing interventions that alleviate PTSD symptoms and improve social functioning among PLHA in rural China.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Post-traumatic Stress Disorder Symptoms Among People Living with HIV/AIDS in Rural China

Luo

Lin

et al. 2016

AIDS Behav

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“…Maladaptation of the stress response is apparent in people with chronic or overwhelming stress and may be relevant in HIV infection . Resilience is the capacity to appropriately respond and recover from stress and is linked to both the perception of an event as stressful and the biologic changes that respond to and appropriately terminate a stress response.…”

Section: Diseases Accelerate the Appearance Of Aging Phenotypes In Humentioning

confidence: 99%

Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

Kohanski

Deeks

Gravekamp

et al. 2016

Annals of the New York Academy of Sciences

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Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the focus was on the role of aging in susceptibility to disease and disability, the other side of this relationship, which is the contribution of disease to aging, has been less explored at the molecular/cellular level. Indeed, the role of childhood or early adulthood exposure to chronic disease and/or treatment on accelerating aging phenotypes is well known in epidemiology, but the biological basis is poorly understood. A recent summit co-organized by the National Institutes of Health GeroScience Interest Group and the New York Academy of Sciences explored these relationships, using three chronic diseases as examples: cancer, HIV/AIDS, and diabetes. The epidemiological literature clearly indicates that early exposure to any of these diseases and/or their treatments results in an acceleration of the appearance of aging phenotypes, including loss of functional capacity and accelerated appearance of clinical symptoms of aging-related diseases not obviously related to the earlier event. The discussions at the summit focused on the molecular and cellular relationships between each of these diseases and the recently defined molecular and cellular pillars of aging. Two major conclusions from the meeting include the desire to refine an operational definition of aging and to concomitantly develop biomarkers of aging, in order to move from chronological to physiological age. The discussion also opened a dialogue on the possibility of improving late-life outcomes in patients affected by chronic disease by including age-delaying modalities along with the standard care for the disease in question.

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“…We also excluded articles from non-US settings to limit cultural and health system factors potentially affecting the applicability of results to the US context. Finally, this review did not address intrapersonal outcomes, such as psychological resilience and social support, that are associated with improved well-being and reduced HIV-related risk behaviors among some key populations (Fang et al, 2015), as well as stress, which is associated with poorer clinical outcomes (e.g., higher viral load) (Weinstein & Li, 2016). As HIV care delivery models evolve, the role of advanced practitioners and social support in promoting resilience may warrant consideration (De Santis, Florom-Smith, Vermeesch, Barroso, & DeLeon, 2013).…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of HIV care delivery models in the US: a systematic review

et al. 2016

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With over 1 million people living with HIV, the US faces national challenges in HIV care delivery due to an inadequate HIV specialist workforce and the increasing role of non-communicable chronic diseases in driving morbidity and mortality in HIV-infected patients. Alternative HIV care delivery models, which include substantial roles for advanced practitioners and/or coordination between specialty and primary care settings in managing HIV-infected patients, may address these needs. We aimed to systematically review the evidence on patient-level HIV-specific and primary care health outcomes for HIV-infected adults receiving outpatient care across HIV care delivery models. We identified randomized trials and observational studies from bibliographic and other databases through March 2016. Eligible studies met pre-specified eligibility criteria including on care delivery models and patient-level health outcomes. We considered all available evidence, including non-experimental studies, and evaluated studies for risk of bias. We identified 3605 studies, of which 13 met eligibility criteria. Of the 13 eligible studies, the majority evaluated specialty-based care (9 studies). Across all studies and care delivery models, eligible studies primarily reported mortality and antiretroviral use, with specialty-based care associated with mortality reductions at the clinician and practice levels and with increased antiretroviral initiation or use at the clinician level but not the practice level. Limited and heterogeneous outcomes were reported for other patient-level HIV-specific outcomes (e.g., viral suppression) as well as for primary care health outcomes across all care delivery models. No studies addressed chronic care outcomes related to aging. Limited evidence was available across geographic settings and key populations. As redesign of care delivery in the US continues to evolve, better understanding of patient-level HIV-related and primary care health outcomes, especially across different staffing models and among different patient populations and geographic locations, is urgently needed to improve HIV disease management.

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The relationship between stress and clinical outcomes for persons living with HIV/AIDS: a systematic review of the global literature

Cited by 37 publications

References 43 publications

Post-traumatic Stress Disorder Symptoms Among People Living with HIV/AIDS in Rural China

Post-traumatic Stress Disorder Symptoms Among People Living with HIV/AIDS in Rural China

Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

Clinical outcomes of HIV care delivery models in the US: a systematic review

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