The relationship between <sup>18</sup>F‐<scp>FDG</scp>‐<scp>PETCT</scp>‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

McSorley, Stephen T.; Khor, Bo Yuan; Tsang, Kwong Y.; Colville, David; Han, Sai; Horgan, Paul G.; McMillan, Donald C.

doi:10.1111/codi.13973

Cited by 14 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study conducted in 73 advanced HNSCC patients (Ohashi et al 2020 ) proved that WBC count was significantly correlated with 18 F-FDG PET/CT parameters, and speculated that tumor with upregulated aerobic glycolysis produce large amounts of lactic acid and cytokines and might mediate systemic inflammation via the lactic acid-induced IL-23/IL-17 pathway. Several studies also confirmed the relationship between PET-CT volumetric metabolic parameters and NLR/PLR in SCLC, NSCLC, cervical carcinoma and colorectal cancer (Du et al 2019 ; McSorley et al 2018 ; Mirili et al 2019 ; Wang et al 2020 ).…”

Section: Discussionmentioning

confidence: 77%

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Hui

Wei

Ren

et al. 2020

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose The combined small-cell lung cancer (c-SCLC) is rare and has unique clinicopathological futures. The aim of this study is to investigate 18 F-FDG PET/CT parameters and clinicopathological factors that influence the prognosis of c-SCLC. Methods Between November 2005 and October 2014, surgical-resected tumor samples from c-SCLC patients who received preoperative 18 F-FDG PET/CT examination were retrospectively reviewed. The maximum standardized uptake value (SUV max), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to evaluate metabolic parameters in primary tumors. The survivals were evaluated with the Kaplan-Meier method. Univariate and multivariate analyses were used to evaluate potential prognostic factors. Results Thirty-one patients were enrolled, with a median age of 62 (range: 35 − 79) years. The most common mixed component was squamous cell carcinoma (SCC, n = 12), followed by large-cell carcinoma (LCC, n = 7), adenocarcinoma (AC, n = 6), spindle cell carcinoma (n = 4), adenosquamous carcinoma (n = 1) and atypical carcinoid (n = 1). The median follow-up period was 53.0 (11.0-142.0) months; the 5-year overall survival (OS) and progression-free survival(PFS) rate were 48.4% and 35.5%, respectively. Univariate survival analysis showed that gender, smoking history, tumor location were associated with PFS (P = 0.036, P = 0.043, P = 0.048), SUVmax and TNM stage were closely related to PFS in both Mixed SCC and non-SCC component groups (P = 0.007, P = 0.048). SUV max , smoking history, tumor size and mixed SCC component were influencing factors of OS in patients (P = 0.040, P = 0.041, P = 0.046, P = 0.029). Multivariate survival analysis confirmed that TNM stage (HR = 2.885, 95%CI: 1.323-6.289, P = 0.008) was the most significantly influential factor for PFS. High SUV max value (HR = 9.338, 95%CI: 2.426-35.938, P = 0.001) and mixed SCC component (HR = 0.155, 95%CI: 0.045-0.530, P = 0.003) were poor predictors for OS. Conclusion Surgical-resected c-SCLCs have a relatively good prognosis. TNM stage is the most significant factor influencing disease progression in surgical-resected c-SCLCs. SUVmax and mixed NSCLC components within c-SCLCs had a considerable influence on the survival. Both high SUVmax and mixed SCC component are poor predictors for patients with c-SCLCs.

show abstract

Section: Discussionmentioning

confidence: 77%

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Hui

Wei

Ren

et al. 2020

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…In addition, the circulating neutrophils could act as a surrogate for tumor-associated neutrophils, which act as adhesive adapters between circulating tumor cells and the metastatic target and play an important role in tumor angiogenesis and growth by secreting vascular endothelial growth factor and matrix metalloproteinase [15,17]. On the other hand, lymphocytes possess an anti-tumor effect by inducing tumor cell apoptosis and mediating antibody-dependent cell-mediated cytotoxicity [22][23][24]. Moreover, memory T-cells are considered to have a crucial role in carcinogenesis [25].…”

Section: Discussionmentioning

confidence: 99%

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

Wang

Zhao

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background: We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcinoma (ESCC) after concurrent chemoradiotherapy (CCRT). Methods: We retrospectively analyzed 163 newly diagnosed ESCC patients treated with CCRT. Eighty patients (training set) were randomly selected to generate cutoff SUVmean and NLR values by receiver operating characteristic (ROC) curve analysis and to establish a predictive model by using the independent predictors of treatment outcomes. Then, we evaluated the performance of the prediction model regarding treatment outcomes in the testing set (n = 83) and in all sets. Results: A high SUVmean (> 5.81) and high NLR (> 2.42) at diagnosis were associated with unfavorable treatment outcomes in patients with ESCC. The prediction model had a better performance than the simple parameters (p < 0.05). With a cutoff value of 0.77, the prediction model significantly improved the specificity and positive predictive value for treatment response (88.9 and 92.1% in the training set, 95.8 and 97.1% in the testing set, and 92.2 and 91.8% in all sets, respectively). Conclusions: The pretreatment SUVmean and NLR were independent predictors of treatment response in ESCC patients treated with CCRT. The predictive model was constructed based on these two parameters and provides a highly accurate tool for predicting patient outcomes.

show abstract

“…The remaining 10 articles had their bibliographies reviewed in a systematic manner. This identified a further 2 articles to be included in the final analysis, leading to final figure of 12 articles considered in the present systematic review (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Study Selection Processmentioning

confidence: 99%

The Relationship Between Tumor Glucose Metabolism and Host Systemic Inflammatory Responses in Patients with Cancer: A Systematic Review

et al. 2018

View full text Add to dashboard Cite

One of the most important and long recognised characteristics of tumour cells is their dysregulated cellular energetics with anaerobic driven glucose uptake. In patients with cancer the prognostic value of the systemic inflammatory response has been well established and the recent combination of PET and CT scanning combines the assessment of tumour physiological activity with detailed anatomical localisation. The aim of this study was to carry out a systematic review of the assessment of the relationship between both the tumour and host inflammatory responses using PETCT. An extensive literature review using targeted subject headings was carried out in the US National Library of Medicine, the Excerpta Medica database and Cochrane Database of Systematic Reviews until the 31st March 2018. On completion of the online search, the title and abstracts of each identified study was examined for relevance. Studies with duplicate datasets, not available in English and that did not have full text availability were excluded. Full texts of relevant articles were obtained and were then examined to identify any further relevant articles. Twelve studies containing 2,588 patients were included in the final analysis. All of the included studies used the FDG tracer in PETCT imaging and had biochemical assessment of the systemic inflammatory response. The majority of studies showed a direct relationship between the tumour and bone marrow glucose uptake and host systemic inflammatory responses as measured by C-Reactive Protein (CRP) ( = 2), albumin ( = 2), White Cell Count (WCC) ( = 3), neutrophils ( = 2) and platelets ( = 2). The majority of the studies ( = 8) also showed a direct relationship between tumour and bone marrow glucose uptake and poor outcomes. This review suggests a direct relationship between the tumour and bone marrow glucose uptake and host systemic inflammation. This may suggest new approaches for more optimal therapeutic targeting and monitoring strategies in patients with cancer.

show abstract

The relationship between ¹⁸F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

Abstract: The present study reports a direct association between F-FDG-PETCT-derived measures of tumour metabolism and systemic inflammation in patients with recurrent colorectal cancer.

Cited by 14 publications

References 20 publications

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

The Relationship Between Tumor Glucose Metabolism and Host Systemic Inflammatory Responses in Patients with Cancer: A Systematic Review

Contact Info

Product

Resources

About

The relationship between 18F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

Abstract: The present study reports a direct association between F-FDG-PETCT-derived measures of tumour metabolism and systemic inflammation in patients with recurrent colorectal cancer.

Cited by 14 publications

References 20 publications

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

The Relationship Between Tumor Glucose Metabolism and Host Systemic Inflammatory Responses in Patients with Cancer: A Systematic Review

Contact Info

Product

Resources

About

The relationship between ¹⁸F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer