The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients

Takii, Michiaki; Uchigata, Yasuko; Kishimoto, Junji; Morita, Chihiro; Hata, Takehisa; Nozaki, Tomoyoshi; Kawai, Keisuke; Iwamoto, Yasuhiko; Sudo, Nobuyuki; Kubo, Chiharu

doi:10.1111/j.1399-5448.2010.00708.x

Cited by 34 publications

(30 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Very recently, Acres et al [243] and Hornig and Lipkin [104] hypothesize that AN is an autoimmune disease and may also be associated with major histocompatibility complex (MHC) gene polymorphisms. Indeed, the development of type 1 diabetes in adolescence seems to place girls at risk for the subsequent development of AN and BN [244, 245]. Thus, autoimmune disorders are associated with increased secretion of leptin, whereas AN and BN are conditions of reduced leptin production.…”

Section: Discussionmentioning

confidence: 99%

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Smitka

Papežová

Vondra

et al. 2013

International Journal of Endocrinology

View full text Add to dashboard Cite

Eating disorders such as anorexia (AN) and bulimia nervosa (BN) are characterized by abnormal eating behavior. The essential aspect of AN is that the individual refuses to maintain a minimal normal body weight. The main features of BN are binge eating and inappropriate compensatory methods to prevent weight gain. The gut-brain-adipose tissue (AT) peptides and neutralizing autoantibodies play an important role in the regulation of eating behavior and growth hormone release. The mechanisms for controlling food intake involve an interplay between gut, brain, and AT. Parasympathetic, sympathetic, and serotoninergic systems are required for communication between brain satiety centre, gut, and AT. These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies. This extensive and detailed report reviews data that demonstrate that hunger-satiety signals play an important role in the pathogenesis of eating disorders. Neuroendocrine dysregulations of the AT-gut-brain axis peptides and neutralizing autoantibodies may result in AN and BN. The circulating autoantibodies can be purified and used as pharmacological tools in AN and BN. Further research is required to investigate the orexigenic/anorexigenic synthetic analogs and monoclonal antibodies for potential treatment of eating disorders in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Smitka

Papežová

Vondra

et al. 2013

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…This may suggest that poor control in girls who were diagnosed early may reflect deterioration of glycemic control associated with longer disease duration rather intentional than insulin omission for weight loss. The age of onset of type 1 diabetes mellitus and shorter disease duration were reported to be associated with excess risk for subsequent development of severe eating disorders in female patients …”

Section: Discussionmentioning

confidence: 99%

Detecting intentional insulin omission for weight loss in girls with type 1 diabetes mellitus

Pinhas‐Hamiel

Hamiel

Greenfield

et al. 2013

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

“…Providers must pay special attention to disordered eating behaviors, even those that are sub-threshold for diagnostic criteria [8]. According to the Center for Disease Control's Youth Risk Behavior Surveillance, a national survey of risk behaviors of high school students, 45% of high school students reported trying to lose weight.…”

Section: Prevalence In General Population and In Those With Type 1 DImentioning

confidence: 99%

“…Adolescents' frequent use of social media may also increase their risk for disordered eating behavior, as it places importance on appearance and facilitates social comparisons [20]. In addition, one study found that females diagnosed with type 1 diabetes between the ages of 7 and 18 years were at a significantly higher risk for developing an eating disorder than those who were diagnosed with diabetes in either young childhood or early adulthood [8]. Thus, it is imperative that health care providers are aware of the increased risk of eating disorder in this age group.…”

Section: Risk Factorsmentioning

confidence: 99%

Eating Disorders and Disordered Eating in Type 1 Diabetes: Prevalence, Screening, and Treatment Options

Hanlan¹,

et al. 2013

View full text Add to dashboard Cite

This review is focused on the prevalence of eating disorders and disordered eating behaviors in individuals with type 1 diabetes. Recent research indicates higher prevalence rates of eating disorders among people with type 1 diabetes, as compared to their peers without diabetes. Eating disorders and disordered eating behaviors – especially insulin omission – are associated with poorer glycemic control and serious risk for increased morbidity and mortality. Screening should begin in pre-adolescence and continue through early adulthood, as many disordered eating behaviors begin during the transition to adolescence and may persist for years. Available screening tools and treatment options are reviewed. Given the complexity of diabetes management in combination with eating disorder treatment, it is imperative to screen early and often, in order to identify those most vulnerable and begin appropriate treatment in a timely manner.

show abstract

The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients

Abstract: The development of type 1 diabetes in preadolescence or adolescence seems to place girls at risk for the subsequent development of AN or BN. Careful attention should be paid to these high-risk patients.

Cited by 34 publications

References 26 publications

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Detecting intentional insulin omission for weight loss in girls with type 1 diabetes mellitus

Eating Disorders and Disordered Eating in Type 1 Diabetes: Prevalence, Screening, and Treatment Options

Contact Info

Product

Resources

About