The relationship between the cusp pattern and plural stem cell compartments in guinea pig cheek teeth by chasing BrdU-labeling

Hashimoto, Emi; Nakakura-Ohshima, Kuniko; Kenmotsu, Shin-ichi; Suzuki, Hiromu; Nakasone, Naohiro; Saito, Chikara; Harada, Hidemitsu; Ohshima, Hayato

doi:10.1679/aohc.71.317

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…To test this hypothesis further, we examined guinea pigs, which have continuously growing incisors and molars (Hashimoto E, 2008). In guinea pigs injected with BrdU daily for 10 days, most of the cells in the incisor mesenchyme incorporated BrdU, except for a group of cells surrounding the NVB (Fig.…”

Section: Resultsmentioning

confidence: 99%

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

et al. 2014

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Mesenchymal stem cells (MSCs) are typically defined by their in vitro characteristics, and as a consequence the in vivo identity of MSCs and their niches are poorly understood. To address this issue, we used lineage tracing in a mouse incisor model and identified the neurovascular bundle (NVB) as an MSC niche. We found that NVB sensory nerves secrete Shh protein, which activates Gli1 expression in periarterial cells that contribute to all mesenchymal derivatives. These periarterial cells do not express classical MSC markers used to define MSCs in vitro. In contrast, NG2+ pericytes represent an MSC subpopulation derived from Gli1+ cells; they express classical MSC markers and contribute little to homeostasis but are actively involved in injury repair. Likewise, incisor Gli1+ cells but not NG2+ cells exhibit typical MSC characteristics in vitro. Collectively, we demonstrate that MSCs originate from periarterial cells and are regulated by Shh secretion from a NVB.

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Section: Resultsmentioning

confidence: 99%

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

et al. 2014

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“…The tooth is composed of a core of dentin covered by a layer of enamel on all axial surfaces except the buccal surface of the upper molars and the lingual surface of the lower molars. 34 The rodent incisor shows a single cone appearance in the frontal sections covered by enamel on the labial side, and it possesses only one apical bud. The vole molar may possess 17 apical buds in the apical end of a tooth germ.…”

Section: 4mentioning

confidence: 99%

“…The vole molar may possess 17 apical buds in the apical end of a tooth germ. 7,34 Thus, the number of apical buds may determine the shape of continuously growing teeth. In addition, this study clearly demonstrated Shh expression in the IEE and supra-IEE coincides with the enamel-related epithelium.…”

Section: 4mentioning

confidence: 99%

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

Nakatomi

Saito

et al. 2015

Archives of Oral Biology

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Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth

Seino

Nakatomi

Ida‐Yonemochi

et al. 2019

Journal of Oral Biosciences

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The relationship between the cusp pattern and plural stem cell compartments in guinea pig cheek teeth by chasing BrdU-labeling

Cited by 5 publications

References 37 publications

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth

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