The Relationship between the Drug Delivery Properties of a Formulation of Teriparatide Microneedles and the Pharmacokinetic Evaluation of Teriparatide Administration in Rats

Oh, Yujeong; Kang, Nae‐Won; Jeong, Hyerin; Sohn, Seo-Yeon; Jeon, Yae-Eun; Yu, Na-Young; Hwang, Yura; Kim, Sun Kyung; Kim, Dae‐Duk; Park, Jung Hwan

doi:10.1007/s11095-022-03254-6

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…This study suggests that microneedle delivery may be a viable alternative strategy to calcitonin delivery. Oh et al [ 154 ] prepared two teriparatide microneedles with different dissolution rates using sucrose and sodium carboxymethyl cellulose (CMC-Na), respectively. In the in vitro dissolution test, it took 30 min for CMC microneedles to release 80% of teriparatide, while it was 10 min for sucrose microneedles.…”

Section: Delivery Vehicles and Strategies For Anti-op Drugsmentioning

confidence: 99%

Drug Delivery and Therapy Strategies for Osteoporosis Intervention

Ma,

Zeng,

Yang

et al. 2023

Molecules

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With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or formulation strategy can achieve targeted drug delivery to the bone, diminish side effects, improve bioavailability, and prolong the in vivo residence time, thus effectively curing osteoporosis. This review expounds on the pathogenesis of OP and the clinical medicaments used for OP intervention, proposes the design approach for anti-OP drug delivery, emphatically discusses emerging novel anti-OP drug delivery systems, and enumerates anti-OP preparations under clinical investigation. Our findings may contribute to engineering anti-OP drug delivery and OP-targeting therapy.

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Section: Delivery Vehicles and Strategies For Anti-op Drugsmentioning

confidence: 99%

Drug Delivery and Therapy Strategies for Osteoporosis Intervention

Ma,

Zeng,

Yang

et al. 2023

Molecules

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“…TA-coated MNA was first introduced by laminating a TA-containing formulation on solid microneedles made of titanium or polylactic acid [ 28 , 41 , 42 ]. However, the biocompatibility of materials in solid MNA has been shown to increase the risk of inflammation, infection, and irritation, and redness at the perforations after application and accidental breakage of the solid MNA has been reported [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Clinical Weekly-Dose Teriparatide Acetate Encapsulated Dissolving Microneedle Patch for Efficient Treatment of Osteoporosis

Sim

Kang

Yang³

et al. 2022

Polymers

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Teriparatide acetate (TA), which directly promotes bone formation, is subcutaneously injected to treat osteoporosis. In this study, TA with a once-weekly administration regimen was loaded on dissolving microneedles (DMNs) to effectively deliver it to the systemic circulation via the transdermal route. TA activity reduction during the drying process of various TA polymer solutions formulated with hyaluronic acid and trehalose was monitored and homogeneities were assessed. TA-DMN patches fabricated using centrifugal lithography in a two-layered structure with dried pure hyaluronic acid on the base layer and dried TA polymer solution on the top layer were evaluated for their physical properties. Rhodamine-B-loaded TA-DMNs were found to form perforations when inserted into porcine skin using a shooting device. In addition, 87.6% of TA was delivered to the porcine skin after a 5-min TA-DMN patch application. The relative bioavailability of TA via subcutaneous injection was 66.9% in rats treated with TA-DMN patches. The maximal TA concentration in rat plasma was proportional to the number of patches used. Therefore, the TA-DMN patch fabricated in this study may aid in the effective delivery of TA in a patient-friendly manner and enhance medical efficacy in osteoporosis treatment.

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