In a clinic-based study, the extent to which diabetes knowledge, attitude and compliance related to glycemic control was explored. Three hundred Saudi diabetic women aged 20 years and above were randomly selected from the register of the Diabetes and Endocrine Centre in Dammam, in the Eastern Province of Saudi Arabia and personally interviewed using a prestructured questionnaire. As an index of glycemic control, the glycated hemoglobin was assayed using a microcolumn technique. The main findings were: generally low score levels of knowledge, attitude and compliance. The mean glycated hemoglobin was significantly higher in type I (IDDM) (10.2 ± 2.2%) than in type 2 (NIDDM) diabetic respondents (9.1 ± 2.0%), P = 0.001. Evidence from this study suggests there is a need for sustained active patient education, support and evaluation, in order to increase patient involvement and self-reliance in the management of their diabetes. It is recommended that diabetes care be principally the responsibility of appropriately trained and culturally compatible members of the primary health care team working in partnership with other secondary care services. Medical audit of diabetes care at the primary health care level would improve clinical performance in this field. [3]. These rates are much higher than the 1.2% in the UK [4] but lower than the 35% among Pima Indians of Arizona [5]. It is suspected that diabetic patients find it difficult to comply with their treatment, especially when dietary measures are involved. This difficulty is reflected in their blood glucose level and body weight and may in the great part be due to the lack of appropriate perception of the disease and its management resulting in poor compliance and hence suboptimal glycemic control. Since optimal glycemic control reduces acute and chronic complications of diabetes [6], it is important that measures to improve diabetes care be adopted.There are many factors associated with the epidemiology of DM, such as obesity and genetic predisposition [4]. Bennett et al [4] studied the epidemiology of DM among Pima Indians and concluded that obesity may be a precipitating factor in the development of DM, but this can only be verified by long-term prospective incidence studies on the relationship between diabetes and obesity.