The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: An analysis from the ICE Prospective Cohort Study (ICE-PCS)

Dickerman, Stuart; Abrutyn, Elías; Baršić, Bruno; Bouza, Emilio; Cecchi, Enrico; Moreno, Asunción; Doco‐Lecompte, T.; Eisen, Damon P.; Fortes, Cláudio Querido; Fowler, Vance G.; Lerakis, Stamatios; Miró, José M.; Pappas, Paul; Peterson, Gail; Rubinstein, Ethan; Sexton, Daniel J.; Suter, Fredy; Tornos, Pilar; Verhagen, Dominique W M; Cabell, Christopher H.

doi:10.1016/j.ahj.2007.07.023

Cited by 322 publications

(196 citation statements)

References 30 publications

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“…Among patients not on warfarin, the CVC frequency after initiation of antibiotic treatment was 7%. The low frequency of cerebral emboli after initiation of antibiotics is well known [23] and emphasizes that early diagnosis of IE is of major importance to reduce the number of cerebral complications.…”

Section: Discussionmentioning

confidence: 99%

Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis

Snygg‐Martin

Rasmussen

Hassager

et al. 2010

Eur J Clin Microbiol Infect Dis

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Anticoagulant therapy has been anticipated to increase risk of cerebrovascular complications (CVC) in native valve endocarditis (NVE). This study investigates the relationship between ongoing oral anticoagulant therapy and incidence of symptomatic CVC in left-sided NVE. In a prospective cohort study CVC incidence was compared between NVE patients with and without ongoing warfarin. Among 587 NVE episodes, 48 (8%) occurred in patients on warfarin. A symptomatic CVC was seen in 144 (25%) patients with only 3 on warfarin.CVC were significantly less frequent in patients on warfarin (6% vs. 26 %, OR 0.20, p=0.006).No increase in haemorrhagic lesions was detected in patients on warfarin. Staphylococcus aureus aetiology

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Section: Discussionmentioning

confidence: 99%

Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis

Snygg‐Martin

Rasmussen

Hassager

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…In one study including 1437 patients with left-sided IE receiving appropriate therapy, the incidence of stroke fell from 4.8 to 1.7 per 1000 patient days between the first and second week of therapy. 10 Development of metastatic abscess occurs as a sequela of septic embolization. Patients with splenic abscess may only present with persistent fever and/or recurrent bacteremia during or after completion of antimicrobial therapy.…”

Section: Discussionmentioning

confidence: 99%

Splenic Infarction in a Man with Active Drug Use

Akhrass¹,

Abdallah²,

Ammisetty³

et al. 2017

MOJCR

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Splenic infarction is a common finding in patients of infective endocarditis due to septic emboli of the spleen. However, the occurrence of acute abdominal pain as an initial manifestation of endocarditis is unusual. Herein, we report a case of splenic infarct and infective endocarditis caused by Streptococcus constellatus cured by antibiotic treatment and valve replacement without the aid of splenic intervention.

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“…Antibiyotik tedavisi, emboli riskini azaltmaktadır. 34 10 mm'den büyük vejetasyonla- Abdullah DOĞAN et al…”

Section: Cerrahi̇ Tedavi̇unclassified

Infective Endocarditis: Diagnosis, Treatment and Prevention: Review

Doğan¹,

Gürbüz²

2016

Turkiye Klinikleri J Cardiovasc Sci

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The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: An analysis from the ICE Prospective Cohort Study (ICE-PCS)

Cited by 322 publications

References 30 publications

Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis

Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis

Splenic Infarction in a Man with Active Drug Use

Infective Endocarditis: Diagnosis, Treatment and Prevention: Review

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