The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Scuteri, Angelo; Franco, Oscar H.; Majiid, AlGhatrif; Badarienė, Jolita; Boytsov, S.; Cheng, Hao-Min; Choi, Seong-Woo; Cucca, Francesco; Buyzere, Marc L. De; Delitala, Alessandro; Dörr, Marcus; Engström, Gunnar; Hofman, Albert; Jeong, Seul-Ki; Kweon, Sun‐Seog; Langlois, Michel; Lee, Younghoon; Mattace-Raso, Francesco; Melander, Olle; Morrell, Christopher; Park, Kyeong-Soo; Rietzschel, Ernst; Ryliškienė, Kristina; Ryliškytė, Ligita; Schminke, Ulf; Schlessinger, David; Shin, Min Ho; Irina, Strazhesko; Sung, Shih‐Hsien; Olga, Tkacheva; Völzke, Henry; Lakatta, Edward G.; Nilsson, Peter M.

doi:10.1016/j.atherosclerosis.2016.10.032

Cited by 16 publications

(18 citation statements)

References 21 publications

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“…Several observational studies have described the frequent association between high blood pressure values and MetS, however, the interrelationship with obesity or other risk situations, such as alterations in glucose metabolism, suggests that the basis of this epidemiological association could be related to common physiopathological implications [42,43]. …”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Martínez-Torres

Correa-Bautista

González-Ruíz

et al. 2017

IJERPH

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Metabolic syndrome (MetS) is one of the major public health problems worldwide. The objective of the present study is to investigate the prevalence and the associated variables of MetS in Colombian collegiate students. This cross-sectional study included a total of 890 (52% women) healthy collegiate students (21.3 ± 3.2 years old). The prevalence of MetS was determined by the definition provided by the International Diabetes Federation (IDF). We further examined associations between the prevalence of MetS and related factors, such as age, gender, anthropometric and body composition, weight status, and nutrition profile. The overall prevalence of MetS was 6.0% (95% CI = 4.5% to 7.6%), and it was higher in men than women. The most prevalent components were low high-density lipoprotein cholesterol, high triglyceride levels, waist circumference, and blood pressure levels. The predisposing factors for having a MetS included: being male, over 23 years old, overweight or obese, and having an unhealthy waist-to-height ratio. In conclusion, the occurrence of MetS in young adults is substantial. These findings may be relevant to health promotion efforts for collegiate students in order to develop prospective studies and screening for young adults, which will aid in targeted intervention development to decrease cardiometabolic risk factors.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Martínez-Torres

Correa-Bautista

González-Ruíz

et al. 2017

IJERPH

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“…Definition of MetS based on the presence of at least three components identifies patients with different clusters. Scuteri and colleagues have shown that not all clusters of MetS components are equally associated with subclinical carotid damage. Furthermore, the number of MetS components has been reported to predict subclinical atherosclerosis more reliably than the binary presence/absence of MetS …”

Section: Study Limitations and Strengthsmentioning

confidence: 99%

Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta‐analysis

Cuspidi

Sala

Tadić

et al. 2017

J of Clinical Hypertension

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We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.

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“…The recently developed Metabolic Score for IR (METS‐IR) offers higher concordance with EHC compared with other non–insulin‐based IR indexes; furthermore, METS‐IR includes evaluation of body mass index (BMI), which has shown strong predictive capacity for CVD risk . Overall, METS‐IR evaluates similar components to the metabolic syndrome (MS), which has been associated with age‐related structural and functional changes in arteries and increased intima‐media thickness, which confers an increased risk of hypertension and CVD . Here, we aimed to investigate the correlation of METS‐IR with pulse wave velocity (PWV) and other vascular health surrogates from PWV analysis.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Overall, METS-IR evaluates similar components to the metabolic syndrome (MS), which has been associated with agerelated structural and functional changes in arteries and increased intima-media thickness, which confers an increased risk of hypertension and CVD. 13 Here, we aimed to investigate the correlation of METS-IR with pulse wave velocity (PWV) and other vascular health surrogates from PWV analysis. We also assessed the capacity of METS-IR to predict incident hypertension and its complementary role for the prediction of hypertension along with blood pressure levels and risk prediction models.…”

Section: Introductionmentioning

confidence: 99%

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

Bello‐Chavolla

Antonio-Villa

Vargas‐Vázquez

et al. 2019

J of Clinical Hypertension

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Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non–insulin‐based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non–insulin‐based Metabolic Score for IR (METS‐IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non–insulin‐based IR indexes. We evaluated two populations, a cross‐sectional evaluation of high‐risk individuals (n = 305) with a wide range of metabolic comorbidities and dyslipidemia in whom PWV measurement was performed and a 3‐year prospective cohort of normotensive individuals (N = 6850). We observed a positive correlation between METS‐IR and PWV in the cross‐sectional cohort, which was higher compared with other non–insulin‐based fasting IR indexes; furthermore, PWV values >75th percentile were associated with the upper tercile of METS‐IR values. In the prospective cohort, we observed an increased risk for incident hypertension for the upper METS‐IR tercile (METS‐IR ≥ 46.42; HR: 1.81, 95% CI: 1.41‐2.34), adjusted for known cardiovascular risk factors, and observed that METS‐IR had greater increases in the predictive capacity for hypertension along with SBP and the Framingham Hypertension Risk Prediction Model compared with other non–insulin‐based IR indexes. Therefore, METS‐IR is a novel non–insulin‐based IR index which correlates with arterial stiffness and is a predictor of incident hypertension, complementary to previously validated risk prediction models.

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The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Cited by 16 publications

References 21 publications

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta‐analysis

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

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