The relationship between the particle properties, mechanical behavior, and surface roughness of some pharmaceutical excipient compacts

Narayan, Padma; Hancock, Bruno C.

doi:10.1016/s0921-5093(03)00059-5

Cited by 89 publications

(28 citation statements)

References 10 publications

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“…For example, it is well known that the macroscopic dissolution of tablets depends on the physicochemical properties of the micrometric powders such as contact angle, surface area and particle size (Tran et al, 2015;Leonardi and Salomon, 2013). In the same way, recent studies have been conducted on mechanical properties (Tejedor et al, 2015;Al-Khattawi et al, 2014;Sun, 2011;Narayan and Hancock, 2003). However, the relationship between mechanical properties at different scale is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements

Juban

Nouguier‐Lehon

Briançon

et al. 2015

International Journal of Pharmaceutics

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In the pharmaceutical field, tablets are the most common dosage forms for oral administration. During the manufacture of tablets, measures are taken to assure that they possess a suitable mechanical strength to avoid crumbling or breaking when handling while ensuring disintegration after administration. Accordingly, the tensile strength is an essential parameter to consider. In the present study, microscopic hardness and macroscopic tensile strength of binary tablets made from microcrystalline cellulose and caffeine in various proportions were measured. A relationship between these two mechanical properties was found for binary mixture. The proposed model was based on two physical measurements easily reachable: hardness and tablet density. Constants were determined from the two extreme compositions of this given system. This model was validated with experimental results, and a comparison was made with the one developed by Wu et al. (2005). Both models are relevant for this studied system. Nonetheless, with this model, the tablet tensile strength can be connected with a tablet characteristic at microscopic scale in which porosity is not needed.

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Section: Introductionmentioning

confidence: 99%

Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements

Juban

Nouguier‐Lehon

Briançon

et al. 2015

International Journal of Pharmaceutics

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“…Pharmaceutical tablets are usually made by compaction of powders to achieve specific dimensions and to possess a certain coherent strength. Properties of the powders, such as polymorphism (1), moisture content (2,3), particle shape (4), particle size (5,6), and surface roughness (7), may affect the mechanical properties of the tablets. Crystal structure is one of the most important intrinsic features of a compound.…”

Section: Introductionmentioning

confidence: 99%

Influence of Crystal Structure on the Compaction Properties of n-Alkyl 4-Hydroxybenzoate Esters (Parabens)

Feng

Grant

2006

Pharm Res

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The nanoindentation hardness of the crystals and the tensile strength of directly compressed tablets were each found to correlate directly with the absence or presence of slip planes in the crystal structures of the parabens because slip planes confer greater plasticity. This work presents a molecular insight into the influence of crystal structural features on the tableting performance of molecular crystals in general and of crystalline pharmaceuticals in particular.

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“…This result has been confirmed by a complementary analysis of the surface profiles using fractal parameters; however it was highlighted that fractal parameters are inherently scale sensitive 17 . Narayan and Hancock extended on this study by investigating the effect of particle size on the obtained roughness parameters for compacts with a predilection to deform in either a predominantly plastic or brittle manner 17 .…”

Section: Fig 2: Schematic Diagram Showing the Manufacture Of Single mentioning

confidence: 59%

“…Narayan and Hancock extended on this study by investigating the effect of particle size on the obtained roughness parameters for compacts with a predilection to deform in either a predominantly plastic or brittle manner 17 . They concluded that the relationship was complex in nature and the roughness was influenced by several factors including the yield stress, ductile/brittle transition particle diameter, the compaction stress and the mean particle diameter, hence further studies were required to obtain conclusive correlations ( fig.…”

Section: Fig 2: Schematic Diagram Showing the Manufacture Of Single mentioning

confidence: 99%

Untitled

2011

IJPSR

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The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bilayer tablet has worked as the loading dose and the sustained release layer has maintained the therapeutic plasma drug concentration for prolonged time. Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bilayer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layerseparation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach in producing a quality bi-layer tablet under GMPconditions, especially when high production output is required.

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The relationship between the particle properties, mechanical behavior, and surface roughness of some pharmaceutical excipient compacts

Cited by 89 publications

References 10 publications

Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements

Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements

Influence of Crystal Structure on the Compaction Properties of n-Alkyl 4-Hydroxybenzoate Esters (Parabens)

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