The relationship between the rapid rejection of Haemonchus contortus larvae with cells and mediators in abomasal tissues in immune sheep

Effect of Experimental Infection withHaemonchus contortuson Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats

“…Moreover, medium negative correlations were observed between globules leukocytes and immature worm burden whatever the genetic status. Previous studies in immunized sheep showed that globule leukocytes were implicated in the immune exclusion of challenge larvae [27–29]. Recently, Robinson et al (2010) monitored the local cellular immune response in immunized sheep challenged with H. contortus and observed a peak of globule leukocyte infiltration in the abomasal mucosa at five days after infection [30].…”

Fecundity in adult Haemonchus contortus parasites is correlated with abomasal tissue eosinophils and γδ T cells in resistant Canaria Hair Breed sheep

“…CD4+ T cells seem to play a crucial role in this protection (Gill et al, 1993;Peña et al, 2006) and elevated type 2 immune responses (Th2) defined by increased production of the cytokines IL-4, -5 and -13 and increased tissue eosinophil, mast cell and globule leucocyte numbers are often associated with greater resistance to infection (Balic et al, 2000a(Balic et al, , 2006Lacroux et al, 2006;Kemp et al, 2009). Larval stages have been demonstrated to be susceptible to in vitro killing by eosinophils and closely associated with larvae in resistant animals in vivo (Rainbird et al, 1998;Balic et al, 2006;Terefe et al, 2007).…”

Proteomic analysis of the abomasal mucosal response following infection by the nematode, Haemonchus contortus, in genetically resistant and susceptible sheep

“…For example; detection of the invading nematode has been linked to galectins [30], mucous form and function related proteins (TFF2, GKN3) may limit nematode colonisation [17,31], and polymorphisms in the MHC cluster have been associated with sheep that have an enhanced ability to resist nematode infection [32]. Other factors such as villin (VIL1), keratin (KRT20), and cadherin (CDH2) may play an important role in maintaining epithelial integrity of the abomasal mucosa in response to Haemonchus infection.…”