The Relationship Between the Sighting Eye and Functional and Structural Asymmetries in Glaucoma

Abstract

PURPOSE. To determine the relationship between the sighting eye choice and functional and structural asymmetries in open-angle glaucoma (OAG). METHODS. Two hundred patients with bilateral OAG underwent dominant eye testing using a hole-in-a-card test. The paired eyes were divided into worse and better eyes according to the mean deviation (MD) of visual field (VF) results. Based on the results, patients whose sighting eyes corresponded to eyes with a better VF were designated as group 1, and those whose sighting eyes corresponded to eyes with a worse VF as group 2. RESULTS. The sighting eye corresponded predominantly to eyes with better VFs (P < 0.001). The MD of the worse eye was significantly lower (P ¼ 0.008), and the intereye difference in MD was significantly larger in group 1 than in group 2 (P < 0.001). In a comparison of regional VF threshold values and corresponding retinal nerve fiber layer thickness (RNFLT), the superior and inferior VF threshold values were consistently more deteriorated in the nonsighting worse eyes in group 1 (P ¼ 0.009 and 0.003), compared with the sighting worse eyes in group 2, whereas the corresponding RNFLT was not significantly different between the groups. Multiple linear regression analysis showed that the sighting eye choice (P ¼ 0.047), higher vertical cup-to disc ratio (P ¼ 0.042), older age (P ¼ 0.044), thinner average RNFLT (P ¼ 0.007), and average ganglion cell-inner plexiform layer thickness of worse eyes (P < 0.001) were significantly associated with the MD of the worse eyes. CONCLUSIONS. The sighting eye choice was associated with functional asymmetry between eyes with glaucoma. The functional deterioration was evident in nonsighting eyes with worse VFs.

Ocular Dominance in Open-angle Glaucoma: The Shifting Trend Depending on Stage of the Disease

“…In our previous paper [19], it has shown that the ocular dominance was associated with functional asymmetry between eyes with glaucoma. Considering the relationship between ocular dominance and severity of glaucoma, it is assumed that the choice of ocular dominance may affect the progression of glaucoma.…”

“…Therefore, superior RNFLT was defined as the average of 10, 11, 12, 1, 2 and 3 clock-hour values. Likewise, inferior RNFLT was defined as the average of 5, 6, 7 and 8 clock-hour values [19]. The mean TD of the central cluster The mean TD of the central cluster VF was defined as the average of 12 central data points, whereas the mean TD of the peripheral cluster VF was defined as the average of 40 peripheral data points [19].…”

Structure–Function Relationship and Vision-Related Quality of Life in Glaucoma Secondary to Anterior Uveitis: Comparison with Open Angle Glaucoma

“…Then, the averaged data were converted back to decibel units. The mean TD of the superior VF was calculated as the mean VF TD value of 26 test points in the superior hemifield, and that of the inferior VF was the mean of 26 test points in the inferior hemifield (excluding blind spots, as described in the previous research) [ 28 ].…”

Structure–function Relationship and Vision-related Quality of Life in Glaucoma Secondary to Anterior Uveitis: Comparison with Open Angle Glaucoma

“…The mean TD of the superior VF was calculated as the mean VF TD value of 26 test points in the superior hemi eld, and that of the inferior VF was the mean of 26 test points in the inferior hemi eld (excluding blind spots, as described in the previous research). 27 The center VF was de ned as the average of the 12 central clusters. 28…”