The relationship between the waiting time of postoperative radiotherapy and the prognosis of high grade glioma:a systemic review and meta-analysis

Abstract

Objective:The relationship between the waiting time of postoperative radiotherapy and the prognosis of patients with high-grade glioma is still inconclusive, and we addressed this issue through a systematic review and meta-analysis.Methods:Twenty studies published between 1975 and 2019 about waiting times (WT) of radiotherapy with high-grade glioma were retrieved for meta-analysis.The meta-analysis was performed by converting the effect sizes of different WT into regression coefficients (β) and standard error (SE) to indicate the daily impact of delay on OS.Results:A total of 8462 high-grade glioma patients were included in the 20 studies, and no correlation between WT delay and OS was found in the unadjusted model through meta-analysis (HR=1, 95%CI=0.99-1.01, p=0.962). Meta-regression was used to adjust for other prognostic factors and no clear evidence of the relationship between WT delay and OS was found.Conclusion:This meta-analysis suggests that there is no clear evidence for the effect of delayed radiotherapy on OS with high-grade glioma patients.

Prognostic Factors for Survival of Patients with Glioblastoma in the Southern Region of Morocco

“…According to a recent meta-analysis, the effect of radiotherapy wait time on survival in patients with glioblastoma is still controversial (28); this is difficult to verify in the present study, as the majority of patients started radiotherapy only after six weeks of surgery, which can be explained by the long waiting time due to the lack of treatment facilities. The results of our study indicated that geographical origin is a predictor of overall survival, with better overall survival observed in rural patients compared to urban patients, which might be explained by the environmental factors of patients from rural areas; future studies will be necessary to confirm and deepen these findings.…”